Reactions of CF3-enones with arenes under superelectrophilic activation: a pathway to trans-1,3-diaryl-1-CF3-indanes, new cannabinoid receptor ligands

4-Aryl-1,1,1-trifluorobut-3-en-2-ones ArCH[double bond, length as m-dash]CHCOCF3 (CF3-enones) react with arenes in excess of Brønsted superacids (TfOH, FSO3H) to give, stereoselectively, trans-1,3-diaryl-1-trifluoromethyl indanes in 35-85% yields. The reaction intermediates, the O-protonated ArCH[double bond, length as m-dash]CHC(OH(+))CF3 and the O,C-diprotonated ArHC(+)CH2C(OH(+))CF3 species, have been studied by means of (1)H, (13)C, (19)F NMR, and DFT calculations. Both types of the cations may participate in the reaction, depending on their electrophilicity and electron-donating properties of the arenes. The formation of CF3-indanes is a result of cascade reaction of protonated CF3-enones to form chemo-, regio- and stereoselectively three new C-C bonds. The obtained trans-1,3-diaryl-1-trifluoromethyl indanes were investigated as potential ligands for cannabinoid receptors CB1 and CB2 types. The most potent compound showed sub-micromolar affinity for both receptor subtypes with a 6-fold selectivity toward the CB2 receptor with no appreciable cytotoxicity toward SHSY5Y cells.

Die Mischna, Kilʾajim (Verbotene Mischgattungen) : [Seder 1, Zeraim, Traktat 4]

Text, Übers. u. Erklärung nebst e. textkrit. Anhang von Karl Albrecht

Mus Hs 1537 - [Kantate "Herr Gott, dich loben alle wir] : [BWV 130 ; Arie 3, Rezitativ 4, Arie 5]

[Johann Sebastian Bach]

Na 1 Nachlass Max Horkheimer, 651 - "Vorwort zu Alfred Schmidt: Der Begriff der Natur in der Lehre von Marx"; "Vorlesungen über Autorität und Gesellschaft"; "Über Logik"; "Vorlesungsankündigungen" (p. IX 32.1-3-IX 35)

Vorwort von Horkheimer, Max und Ardorno, Theodor W. zu: Schmidt, Alfred: Der Begriff der Natur in der Lehre Marx. Frankfurt am Main 1962, Frankfurter Beiträge zur Soziologie Band 11. Mehrere Typoskripte und zwei Entwürfe, Typoskrip c mit eigenhändigen Korrekturen von Theodor W. Adorno, 2 Blatt; zweiter Entwurf mit handschriftlichen Korrekturen von Friedrich Pollock, 1 Blatt; Schmidt, Alfred: Gutachten über die Inauguraldissertation 'Die Rolle der Natur in der Marxschen Konzeption der Gesselschaft'. Typoskript mit eigenhändigen Korrekturen, 4 Blatt; Typoskript, 7 Blatt; Pollock, Friedrich: Eigenhändige Notize und Korrekturvorschläge zur Dissertation von Alfred Schmidt, 24 Blatt; Vorlesungen über Autorität und Gesellschaft [Columbia University New York]; 1936-37 "Authority and Status in Modern Society"; 1937-38 "Authoritarian Thought and Institutions in Europe"; 1938-39 "Authoritarian Doctrines and modern European Institutions"; Einleitende Vorlesung über Autorität und Gesellschaft, 1936/37 (Max Horkheimer). Drei englsiche Fassungen, eine deutsche Fassung (GS 12, S.39-68); Zweite Vorlesung über Autorität und Gesellschaft (Max Horkheimer). Englische Fassung, Typoskript mit eigenhändigen Korrekturen, 27 Blatt; deutsche Fassung, Typoskript mit eigenhändigen Korrekturen, 20 Blatt (GS 12, S.39-68); "History" (Herbert Marcuse). Typoskript mit eigenhändigen Korrekturen, 7 Blatt; "Empirical Research" (Paul Lazarfeld). Typoskript, 7 Blatt; "Economica" (Friedrich Pollock). Typoskript, 9 Blatt; "Authoritarian State" (Franz Neumann). Typoskript mit handschriftlichen Korrekturen, 18 Blatt; Teilstück, Typoskript mit handschriftlichen Korrekturen, 1 Blatt; "Education" (Leo Löwenthal ?). Typoskript, 6 Blatt; Einleitung in den psychologischen Teil (Fromm). Englische Fassung, Typoskript, 5 Blatt; Abschlußvorlesung: Zusammenfassung (Max Horkheimer). Englische Fassung, Typoskript mit eigenhändigen und handschriftlichen Korrekturen, 9 Blatt; deutsche Fassung, Typoskript, 5 Blatt (GS 12, S. 39-68); Teilstücke (Entwürfe ?) zu den Vorlesungen. Typoskript mit eigenhändigen Korrekturen, 5 Blatt; Eigenhändige Notizen zu den Vorlesungen, 6 Blatt; Literaturlisten. Als Typoskript vervielfältigt, 3 Blatt; Vorlesungsankündigungen. Als Typoskript vervielfältigt, 4 Blatt; Typoskript, 2 Blatt; Ohne Namen: "Errors in Professor Horkheimers Lecture". Stichworte zu sprachlichen Fehlern Max Horkheimers, 4 Blatt; "Über Logik": Vorlesung von Max Horkheimer, 1939. Typoskript mit handschriftlichen Ergänzungen von Herbert Marcuse, 17 Blatt; Typoskript mit eigenhändigen Korrekturen, 10 Blatt (GS 12, S. 69-74); Vorlesungsankündigungen der Institutsmitglieder (1941 ?); Horkheimer, Max: "The Social Psychology of Mass Movements"; Horkheimer, Max: "Modern Utopias and their Social Background"; Adorno, Theodor W.: "Sociology of Art"; Adorno, Theodor W.: "Sociology of Popular Music"; Marcuse, Herbert: "Social and Intelectual Foundations of Modern European Democracy"; Marcuse, Herbert: "The Development of Social Thought in der Modern Era"; Neumann, Franz: "History of Modern Political Thought"; Neumann, Franz: "Sociology of Legal Institutions"; Löwenthal, Leo: "Sociology of Modern Popular Literature"; Löwenthal, Leo: "Social Trends in European Literature since the Renaissance"; Kirchheimer, Otto: "Sociology of Political Institutions"; Kirchheimer, Otto: "Development of Criminological Thought". Typoskript, 13 Blatt; Typoskript, 7 Blatt; Typoskript mit handschriftlichen Korrekturen, 14 Blatt;

A faithful sea. The religious cultures of the mediterranean, 1200-1700. Edited by Adnan A. Husain and K.E. Fleming, Oneworld Publications, Oxford, 2007.ISBN: 1851684964 / 1-85168-496-4, 226 p.

Fil: Samsó, Fernanda. Universidad Nacional de Cuyo. Facultad de Filosofía y Letras

Shell size variation of Neogloboquadrina pachyderma sin. in the Norwegian-Greenland Sea during the last 1.3 Myr

We present measurements of the maximum diameter of the planktonic foraminifer Neogloboquadrina pachyderma sin. from six sediment cores (Ocean Drilling Program sites 643, 644, 907, 909, 985 and 987) from the Norwegian-Greenland Sea. Our data show a distinct net increase in mean shell size of N. pachyderma sin. at all sites during the last 1.3 Ma, with largest shell sizes reached after 0.4 Ma. External factors such as glacial-interglacial variability and carbonate dissolution alone cannot account for the observed variation in mean shell size of N. pachyderma sin. We consider the observed shell size increase to mirror an evolutionary trend towards better adaptation of N. pachyderma sin. to the cold water environment after 1.1-1.0 Ma. Probably, the Mid Pleistocene climate shift and the associated change of amplitude and frequency of glacial-interglacial fluctuations have triggered the evolution of this planktonic foraminifer. Oxygen and carbon stable isotope analyses of different shell size classes indicate that the observed shell size increase could not be explained by the functional concept that larger shells promote increasing sinking velocities during gametogenesis. For paleoceanographic reconstructions, the evolutionary adaptation of Neogloboquadrina pachyderma sin. to the cold water habitat has significant implications. Carbonate sedimentation in highest latitudes is highly dependent on the presence of this species. In the Norwegian-Greenland Sea, carbonate-poor intervals before 1.1 Ma are, therefore, not necessarily related to severe glacial conditions. They are probably attributed to the absence of this not yet polar-adapted species. Further, transfer function and modern analog techniques used for the reconstruction of surface water conditions in high latitudes could, therefore, contain a large range of errors if they were applied to samples older than 1.1-1.0 Myrs.

Porewater and solid-phase phosphorus geochemistry in surface sediments of sediment core GeoB9510-3, GeoB9518-4 and GeoB9519-6

Despite intensive research on the different domains of the marine phosphorus (P) cycle during the last decades, frequently discussed open questions still exist especially on controlling factors for the benthic behaviour of P and its general distribution in sediment-pore water systems. Steady state or the internal balance of all relevant physical and (bio)geochemical processes are amongst the key issues. In this study we present and discuss an extended data set from surface sediments recovered from three locations on the NW African continental slope. Pore water data and results from sequential sediment extractions give clear evidence to the well-known close relationship between the benthic cycles of P and iron. Accordingly, most of the dissolved phosphate must have been released by microbially catalyzed reductive dissolution of iron (oxhydr)oxides. However, rates of release and association of P and iron, respectively, are not directly represented in profiles of element specific sediment compositions. Results from steady-state based transport-reaction modelling suggest that particle mixing due to active bioturbation, or rather a physical net downward transport of P associated to iron (oxyhydr)oxides, is an essential process for the balance of the inspected benthic cycles. This study emphasizes the importance of balancing analytical data for a comprehensive understanding of all processes involved in biogeochemical cycles.