821 resultados para táticas alternativas


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Praziquantel (PZQ) is the drug of choice commonly used for the treatment of shistosomiasis. However, it has low aqueous solubility, which could limit its bioavailability in the body. To circumvent these features, an inclusion complex with hydroxypropyl-beta- cyclodextrin (HP-β-CD) was prepared. Thus, the objective of this work was to prepare and characterize the PZQ/HP-β-CD inclusion complex. Morphological, spectroscopic, and calorimetric analysis showed the first signs of the guest/host interaction. The complexation kinetic analysis was used to determine the kinetic constant and, besides that, it was possible to establish the time consumed to reach equilibrium. Using the solubility isotherm, it was observed that the interaction with HP-β-CD increased 2.4 fold the aqueous solubility of plain PZQ. In vitro cytotoxicity tests, using fibroblast cells, evidenced no toxicity for these cells at the concentrations tested. These results demonstrated that there is a potential use of PZQ in formulations with HP-β-CD.

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The present article, which is one study among others, seeks to understand practices and tactics of day-to-day school, spanning and being spanned by three studies in Mathematics education. The diversity of scenes, people and strategies used by actors in everyday school, considered from the theoretical perspectives of Foucault and Deleuze, shed light on the ways Mathematic alphabetization takes place and evidence regarding what is present in the black box of school culture, in a constant problematization about what a school can do. Maps are presented that establish cartographies, revealing smooth and striated territories, on a path created by the research done in those schools, where life is always invented.

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Analiza la mayor integracion en una economia mundial inestable e incierta, los limites y potencialidades del actual esquema de planificacion, la crisis de los paradigmas economicos, y la necesidad de constituir un nuevo paradigma economico con un enfoque multidisciplinario.

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Incluye Bibliografía

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Analiza los factores que permiten comprender por qué la solución a la crisis no ha sido fácil: la mayor integración en una economía internacional inestable; la crisis de los paradigmas económicos; y los problemas técnicos, políticos e ideológicos que enfrenta el actual esquema de planificación de la región. Esboza algunas ideas acerca de como afrontar estos factores.