Towards conceptualizing reverse service supply chains

Purpose – Recognizing the heterogeneity of services, this paper aims to clarify the characteristics of forward and the corresponding reverse supply chains of different services. Design/methodology/approach – The paper develops a two-dimensional typology matrix, representing four main clusters of services according to the degree of input standardization and the degree of output tangibility. Based on this matrix, this paper develops a typology and parsimonious conceptual models illustrating the characteristics of forward and the corresponding reverse supply chains of each cluster of services. Findings – The four main clusters of service supply chains have different characteristics. This provides the basis for the identification, presentation and explanation of the different characteristics of their corresponding reverse service supply chains. Research limitations/implications – The findings of this research can help future researchers to analyse, map and model forward and reverse service supply chains, and to identify potential research gaps in the area. Practical/implications – The findings of the research can help managers of service firms to gain better visibility of their forward and reverse supply chains, and refine their business models to help extend their reverse/closed-loop activities. Furthermore, the findings can help managers to better optimize their service operations to reduce service gaps and potentially secure new value-adding opportunities. Originality/value – This paper is the first, to the authors ' knowledge, to conceptualize the basic structure of the forward and reverse service supply chains while dealing with the high level of heterogeneity of services.

Second-life retailing: a reverse supply chain perspective

Purpose – The authors examine the role of entrepreneurial business models in the reverse supply chain of apparel/fashion retailers. The purpose of this paper is to offer an alternative approach to the “return to the point of origin” prevalent in the reverse chain of manufacturers but less technically and economically feasible in the case of apparel/fashion retailers. This approach, second-life retailing, not only reduces waste but also democratises consumption. Design/methodology/approach – The paper is based on an extensive literature review, semi-structured interviews with managers of two second-life retailers in Malaysia and observations of a number of stores. Findings – Using the Business Model Canvas, the authors demonstrate the essential characteristics of second-life retailers. Retailers in this study, unlike retailers in the developed world, combine traditional business models with off-price retailing. There is no clear demarcation between the forward and reverse supply chain used to manage first- and second-hand retailing. Practical implications – The paper demonstrates the potential of innovative business models in the reverse supply chain. It encourages managers to look beyond the “return to the point of origin” and seek imaginative alternatives. Such alternatives potentially could result in additional revenue, enhanced sustainability and democratisation of consumption meeting triple bottom line objectives. Originality/value – This paper highlights the importance and relevance of entrepreneurial business models in addressing the reverse supply chain, demonstrating this with the aid of two Malaysian off-price retailers. It also contributes to our nascent knowledge by focusing on emerging markets.

One-step reverse transcriptase polymerase chain reaction for the diagnosis of respiratory syncytial virus in children

Human respiratory syncytial virus (HRSV) is the main cause of acute lower respiratory tract infections in infants and children. Rapid diagnosis is required to permit appropriate care and treatment and to avoid unnecessary antibiotic use. Reverse transcriptase (RT-PCR) and indirect immunofluorescence assay (IFA) methods have been considered important tools for virus detection due to their high sensitivity and specificity. In order to maximize use-simplicity and minimize the risk of sample cross-contamination inherent in two-step techniques, a RT-PCR method using only a single tube to detect HRSV in clinical samples was developed. Nasopharyngeal aspirates from 226 patients with acute respiratory illness, ranging from infants to 5 years old, were collected at the University Hospital of the University of Sao Paulo (HU-USP), and tested using IFA, one-step RT-PCR, and semi-nested RT-PCR. One hundred and two (45.1%) samples were positive by at least one of the three methods, and 75 (33.2%) were positive by all methods: 92 (40.7%) were positive by one-step RT-PCR, 84 (37.2%) by IFA, and 96 (42.5%) by the semi-nested RT-PCR technique. One-step RT-PCR was shown to be fast, sensitive, and specific for RSV diagnosis, without the added inconvenience and risk of false positive results associated with semi-nested PCR. The combined use of these two methods enhances HRSV detection. (C) 2007 Elsevier B.V. All rights reserved.

Effects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cells

Aims: The ATP-binding cassette transporters, ABCA1 and ABCG1, are LXR-target genes that play an important role in reverse cholesterol transport. We examined the effects of inhibitors of the cholesterol absorption (ezetimibe) and synthesis (statins) on expression of these transporters in HepG2 cells and peripheral blood mononuclear cells (PBMCs) of individuals with primary (and nonfamilial) hypercholesterolemia (HC). Materials & methods: A total of 48 HC individuals were treated with atorvastatin (10 mg/day/4 weeks) and 23 were treated with ezetimibe (10 mg/day/4 weeks), followed by simvastatin (10 mg/day/8 weeks) and simvastatin plus ezetimibe (10 mg of each/day/4 weeks). Gene expression was examined in statin- or ezetimibe-treated and control HepG2 cells as well as PBMCs using real-time PCR. Results: In PBMCs, statins and ezetimibe downregulated ABCA1 and ABCG1 mRNA expression but did not modulate NR1H2 (LxR-beta) and NR1H3 (LXR-alpha) levels. Positive correlations of ABCA1 with ABCG1 and of NR1H2 with NR1H3 expressions were found in all phases of the treatments. In HepG2 cells, ABCA1 mRNA levels remained unaltered while ABCG1 expression was increased by statin (1.0-10.0 mu M) or ezetimibe (5.0 mu M) treatments. Atorvastatin upregulated NR1H2 and NR1H3 only at 10.0 mu M, meanwhile ezetimibe (1.0-5.0 mu M) downregulated NR1H2 but did not change NR1H3 expression. Conclusion: Our findings reveal that lipid-lowering drugs downregulate ABCA1 and ABCG1 mRNA expression in PBMCs of HC individuals and exhibit differential effects on HepG2 cells. Moreover, they indicate that the ABCA1 and ABCG1 transcript levels were not correlated directly to LXR mRNA expression in both cell models treated with lipid-lowering drugs.

In silico screening of HIV-1 non-nucleoside reverse transcriptase and protease inhibitors

Two targets, reverse transcriptase (RT) and protease from HIV-1, were used during the past two decades to the discovery of non-nucleoside reverse transcriptase inhibitors (NNRTI) and protease inhibitors (PI) that belong to the arsenal of the antiretroviral therapy. Herein these enzymes were chosen as templates for conducting a computer-aided ligand design. Ligand and structure-based drug designs were the starting points to select compounds from a database bearing more than five million compounds by means of cheminformatic tools. New promising lead structures are retrieved from the database, which are open to acquisition and test. Classes of molecules already described as NNRTI or PI in the literature also came out and were useful to prove the reliability of the workflow, and thus validating the work carried out so far. (c) 2007 Elsevier Masson SAS. All rights reserved.

Using small reverse cycle air conditioners in relocatable classrooms - a case study

A 9-month study of four relocatable school buildings, each retro-fitted with small reverse cycle air conditioners (ACs), was conducted to investigate their effectiveness in heating and cooling the classrooms. A comparison with data from previous studies found the energy used by the ACs for heating these temporary classrooms was only 19–20% of the energy used by individual gas heaters installed in permanent classrooms. When equipment efficiencies were considered, the AC units supplied 20–27% less energy to heat the classrooms. The possible reasons for this reduction in supplied energy are explored in this paper. CO2 emissions for the AC units in heating mode, however, were calculated to be 16% greater than for individual gas heaters. The AC units were also used for cooling and on an average the total annual energy consumption for heating and cooling was found to be 11.6 kWh m−2. Responses to a small survey of staff and students about the use and operation of the conditioners are presented. Their responses were more favourable than the predictions of comfort levels in the classrooms using the Predicted Mean Vote–Predicted Percentage of Dissatisfaction (PMV–PPD) model, which indicated “uncomfortable” conditions on average summer days at 3:00 p.m. and average winter days at 10:00 a.m. Background noise levels in the classrooms with the air conditioners in use were above the recommended maximum design level of 45 dB(A); levels of up to 65 dB(A) were measured.

Effective and strategic use of electronic reverse auctions

This paper reports the findings of an empirical study of Electronic Reverse Auctions (e-RAs). This study seeks to better understand the underlying and emerging issues in e-RAs to comprehend the implications of e-RAs on organizational procurement. The study contributes to practice and research by providing insight into emerging e-RA adoption issues, and by discussing strategies for improving e-RA processes, thus improving the effectiveness of e-RAs.

The influence of marketing logistics networks on organisational performance in Australia and New Zealand

Predictions concerning the influence of traditional and online marketing logistics network competency on organisational performance were tested via structural equation modelling employing a sample of Australian and New Zealand companies. The study finds a significant influence of the use of traditional marketing logistics networks on organisational performance, but that the use of the Web in this regard is yet to have such an influence.

Salvage material logistics management for building demolition project

Building demolition imposes substantial environmental impacts. In particular, large amount of demolition wastes are disposed to landfills. A solution to ease the situation is to maximally reuse and recycle waste building material. Management philosophies such as Just-in-time are applied into demolition project management in order to promote reuse and recycling of demolition wastes. Transportation logistics, widely applied in the manufacturing industry, is ideal to be adopted into demolition projects to optimise waste material production, inventorying, and transportation. In particular, it enables right types and amounts of dismantled building materials to be transferred to right location, and at right time, as required by material demanders. Consequently, waste reuse and recycling can be facilitated. Furthermore, logistics management helps the demolition project team to reduce cost, shorten project duration, and satisfy material demanders. Transportation planning concerns thorough preparation technically and managerially on the demolition site for transportation activities. Information exchange is playing a significant role in delivering and sharing information among project participants, including building owner, demolition project team, potential material demanders, and transporters. This research paper aims to identify the role of transportation logistics in a building demolition project and to analyse inventory control, transportation, and various technical aspects of logistic management for demolition wastes.

Reverse osmosis membrane fouling and its control

Reverse osmosis (RO) membranes can be used to treat ground water, surface water and wastewater, but a major problem in RO membrane applications is fouling. Many studies have investigated the mechanisms of fouling in RO membranes and suggested various methods to control the membrane fouling. This paper reviews several aspects of RO membranes, such as the types of membrane fouling, their effects on RO membrane processes and fouling control technologies, focussed on the appropriate feed pretreatment technologies and cleaning methods, especially on the membrane filtration pretreatment processes, including microfiltration (MF), ultrafiltration (UF) and nanofiltration (NF), which are the new trends in designing a pretreatment system in the application of RO.

Logistics: Our buildings are always particular to places, access, materials, skills and technologies. How do these limits provide us with architectural opportunities?

Presents a discussion on the relations between architecture and spirituality during the 2005 conference of the Royal Architecture Institute of Australia. Reason behind difficulty encountered by architects to associate architecture and spirituality; Inspiration of Jae Cha of architectural firm Light for designing the Bolivian church; View of Kevin O'Brien of Merrima Design on Aboriginal buildings.