Representações parentais e traços disfuncionais de personalidade: Um estudo com uma amostra de estudantes universitários

O objetivo do presente trabalho foi estudar a relação entre representações parentais e traços disfuncionais de personalidade em sujeitos adultos da população não-clínica. Participaram 177 estudantes universitários, dos quais 104 eram mulheres e 73 eram homens, com idades entre os 18 e os 43 anos (M=22,66; DP=4,054). Foi aplicado o Millon Clínical Multiaxial Inventory-II, o Parental Bonding Instrument e o Object Relations lnventory. De acordo com os resultados, existe uma relação entre alguns tipos de traços disfuncionais da personalidade e experiências disruptivas na relação precoce com ambas as figuras parentais, como a falta de autonomia psicológica e instrumental sentida, e com determinados elementos das representações das figuras parentais, como a perceção de uma menor benevolência ou maior punição. Encontram-se também diferenças entre sujeitos do sexo masculino e do sexo feminino no que respeita ao padrão específico de correlações entre traços de personalidade e características da relação e das representações parentais. ABSTRACT: The purpose of this work was to study the relation between parental representations and dysfunctional personality traits in adult subjects from a non-clinical population. Participants were 177 university students, 104 of which were female and 73 were men. Ages ranged from 18 to 43 years old (M=22,66; DP=4,054). The Millon Clinical Multiaxial Inventory-II, the Parental Bonding lnstrument and the Object Relations Inventory were administered. According to the results, there is a relation between certain types of dysfunctional personality traits and disruptive experiences in the early relations with both caregivers, like a perceived lack of psychological and instrumental autonomy, and with certain elements of parental representations, like the perception of less benevolence or a more punitive attitude. Differences between male and female subjects, concerning the specific pattern of correlations between personality traits and parental relations' and representations' characteristics, were also obtained.

Bioelectric Impedance Analysis in the Diagnosis of Vesicoureteral Reflux

Background: Vesicoureteral reflux (VUR) is a common abnormality of the urinary tract in childhood. Objectives: As urine enters the ureters and renal pelvis during voiding in vesicoureteral reflux (VUR), we hypothesized that change in body water composition before and after voiding may be less different in children with VUR. Patients and Methods: Patients were grouped as those with VUR (Group 1) and without VUR (Group 2). Bioelectric impedance analysis was performed before and after voiding, and third space fluid (TSF) (L), percent of total body fluid (TBF%), extracellular fluid (ECF%), and intracellular fluid (ICF%) were recorded. After change of TSF, TBF, ECF, ICF (ΔTSF, ΔTBF%, ΔECF%, ΔICF%), urine volume (mL), and urine volume/body weight (mL/kg) were calculated. Groups 1 and 2 were compared for these parameters. In addition, pre- and post-voiding body fluid values were compared in each group. Results: TBF%, ECF%, ICF%, and TSF in both pre- and post-voiding states and ΔTBF%, ΔECF%, ΔICF%, and ΔTSF after voiding were not different between groups. However, while post-voiding TBF%, ECF% was significantly decreased in Group 1 (64.5 ± 8.1 vs 63.7 ± 7.2, P = 0.013 for TBF%), there was not post-voiding change in TSF in the same group. On the other hand, there was also a significant TSF decrease in Group 2. Conclusions: Bladder and ureter can be considered as the third space. Thus, we think that BIA has been useful in discriminating children with VUR as there was no decreased in patients with VUR, although there was decreased TSF in patients without VUR. However, further studies are needed to increase the accuracy of this hypothesis.

Comparison Between Diuretic Urography (IVP) and Diuretic Renography for Diagnosis of Ureteropelvic Junction Obstruction in Children

Background: Ureteropelvic junction obstruction (UPJO) is one of the most common causes of urinary tract obstruction in children. Several methods are used to diagnose upper urinary tract obstruction including renal ultrasonography (US), intravenous pyelogram (IVP), diuretic renography (DR), magnetic resonance urography (MRU) and antegrade or retrograde pyelography. Nowadays it is suggested to use diuretic renography as the best method for diagnosing of UPJO. There is no comparative study between IVP and DR scan for diagnosis of UPJO in children. Objectives: The aim of the present study was to compare IVP with furosemide injection and diuretic renography in diagnosis of clinically significant UPJO. Patients and Methods: This was a cross sectional study performed in 153 UPJO suspected children (121 boys, 32 girls) based on US findings in cases presented with urinary tract infection (UTI), prenatal hydronephrosis, abdominal/flank pain, abdominal mass and hematuria. Renal ultrasound was used as an initial screening tool for detection of urinary tract abnormality. Vesicoureteral reflux (VUR) was ruled out by voiding cystourethrography (VCUG). Serum creatinin, blood urea nitrogen, urinalysis and urine culture was screened in all cases. IVP with furosemide and DR were performed as soon as possible after the mentioned workup. Results: During a five year period, 46 out of 153 patients were diagnosed as UPJO based on diuretic renography: the age ranged from 4 months to 13 years (mean: 3.1 ± 0.78 years). There was a significant higher (76%) proportion of UPJO in the boys and in the left side (78%). The sensitivity of IVP with furosemide injection in diagnosis of UPJO was 91.3% whereas DR was accepted as standard for diagnostic procedure in diagnosis of UPJO. Conclusions: Although DR is accepted as the best method for diagnosis of UPJO, we found a small sensitivity difference between IVP and DR in kidneys with normal or near normal function. In many settings such as small cities lacking facilities for advanced isotope imaging technology, use of IVP with diuretic maybe an acceptable procedure for diagnosis of UPJO.

Postnatal Evaluation and Outcome of Prenatal Hydronephrosis

Background: Prenatal hydronephrosis (PNH) is dilation in urinary collecting system and is the most frequent neonatal urinary tract abnormality with an incidence of 1% to 5% of all pregnancies. PNH is defined as anteroposterior diameter (APD) of renal pelvis ≥ 4 mm at gestational age (GA) of < 33 weeks and APD ≥ 7 mm at GA of ≥ 33 weeks to 2 months after birth. All patients need to be evaluated after birth by postnatal renal ultrasonography (US). In the vast majority of cases, watchful waiting is the only thing to do; others need medical or surgical therapy. Objectives: There is a direct relationship between APD of renal pelvis and outcome of PNH. Therefore we were to find the best cutoff point APD of renal pelvis which leads to surgical outcome. Patients and Methods: In this retrospective cohort study we followed 200 patients 1 to 60 days old with diagnosis of PNH based on before or after birth ultrasonography; as a prenatal or postnatal detected, respectively. These patients were referred to the nephrology clinic in Zahedan Iran during 2011 to 2013. The first step of investigation was a postnatal renal US, by the same expert radiologist and classifying the patients into 3 groups; normal, mild/moderate and severe. The second step was to perform voiding cystourethrogram (VCUG) for mild/moderate to severe cases at 4 - 6 weeks of life. Tc-diethylene triamine-pentaacetic acid (DTPA) was the last step and for those with normal VCUG who did not show improvement in follow-up examination, US to evaluate obstruction and renal function. Finally all patients with mild/moderate to severe PNH received conservative therapy and surgery was preserved only for progressive cases, obstruction or renal function ≤35%. All patients’ data and radiologic information was recorded in separate data forms, and then analyzed by SPSS (version 22). Results: 200 screened PNH patients with male to female ratio 3.5:1 underwent first postnatal control US, of whom 65% had normal, 18% mild/moderate and 17% severe hydronephrosis. 167 patients had VCUG of whom 20.82% with VUR. 112 patients performed DTPA with following results: 50 patients had obstruction and 62 patients showed no obstructive finding. Finally 54% of 200 patients recovered by conservative therapy, 12.5% by surgery and remaining improved without any surgical intervention. Conclusions: The best cutoff point of anteroposterior renal pelvis diameter that led to surgery was 15 mm, with sensitivity 88% and specificity 74%.

Moderating effects of gender in the relationships between daily stress, coping styles and hopelessness depression in adolescents

The hopelessness depression (HD) theory assumes a number of contributing factors to the development of hopelessness expectations and HD symptoms. Studies carried out to test HD theory have generally supported the prediction that a negative attributional style contributes to the development of hopelessness expectations and HD symptoms, although the evidence is less consistent for adolescents. Due to these inconsistent results, as well as the assumption advanced by HD theory that other factors aside from attributional style may contribute to the development of HD, in this study we examined the potential role of adolescents’ daily stress and coping styles as contributing factors to HD at these ages, and the effects of gender on these relationships. Seiffge-Krenke (1995) showed that stress in daily life plays a particularly relevant role during adolescence and described three coping styles used by adolescents to face daily stress: active and internal approach-oriented styles, which are considered functional and complementary, and avoidant style, considered dysfunctional. In this study, secondary students (N = 480; aged 13–17) completed the Hopelessness Scale (Beck, Weissman, Lester, & Trexler, 1974), the Hopelessness Depression Symptoms Questionnaire (Metalsky & Joiner, 1997), the Problem Questionnaire ((Seiffge-Krenke, 1995) and the Coping Across Situations Questionnaire (Seiffge-Krenke, 1995). To test the role of daily stress and coping styles in the prediction of hopelessness expectations and HD symptoms, two four-step hierarchical multiple regression analyses were conducted. In these analyses, gender was introduced first, daily stress was introduced second, the three coping styles were entered in a third step, and the moderating effects of gender on the associations of the predictor variables (daily stress and each coping style) with the criterion variables (hopelessness expectations or HD symptoms) were introduced in a fourth step. Results showed a moderating effect of gender on the relationship between daily stress and hopelessness expectations, which revealed a significant effect for boys despite the fact that girls experienced more daily stress than boys, thus suggesting an inoculation effect in girls. It was also found a gender-dependent role of coping styles in the prediction of HD symptoms, revealing a protective effect for the active style in girls and for the internal style in boys. This suggests that girls would benefit from being more action-prone and boys more reflection-prone in order to prevent HD. These findings indicate that programmes aimed to promote coping skills in adolescents would benefit from being gender-adapted.

South Road

SOUTH ROAD, a novel told in third-person limited, follows Adrienne Harris as she navigates the trials of her coming-of-age summer and then must deal with the aftermath. 1997: seventeen-year-old Adrienne Harris wants nothing more than to flee her eccentric grandmother’s rule and leave Harbor Point and never look back. When she meets her new neighbors, Adrienne knows her life will never be the same. Adrienne quickly falls in love with the charismatic Quinn Merritt. They decide to keep their relationship a secret since both families disapprove. This secret starts a chain reaction that seemingly leads to the suicide of the troubled and poetic Lucas Merritt. The summer culminates with Adrienne running away, pregnant and heartbroken. 2011: thirty-one-year-old Adrienne is an out of work line cook and single mother. The story opens as Adrienne reluctantly returns home to Harbor Point to care for her ailing grandmother. Once home, Adrienne has to confront the things that haunt her—the summer she met and lost both Merritt brothers, and also her dysfunctional relationship with her grandmother—in order to heal and repair her own life and her relationship with her daughter. In the end, Adrienne discovers many truths that alter her perception of her past in Harbor Point. Adrienne is finally able to move forward and start to build a life for her and her daughter. Harbor Point, the last place in the world Adrienne Harris wanted to be, turns out to be the only place she wants to call home.

Social Capital, HIV Risk Behavior and Substance Use among Recent Latino Immigrants in South Florida

Social capital, or social cohesion or group connectedness, can influence both HIV risk behavior and substance use. Because recent immigrants undergo a change in environment, one of the consequences can be a change in social capital. There may be an association among changes in social capital, and HIV risk behavior and substance use post immigration. The dissertation focused on the interface of these three variables among recent Latino immigrants (RLIs) in South Florida. The first manuscript is a systematic review of social capital and HIV risk behavior, and served as a partial background for the second and third manuscripts. Twelve papers with a measure of social capital as an independent variable and HIV risk as the dependent variable were included in the analysis. Eleven studies measured social capital at the individual level, and one study measured social capital at the group level. HIV risk was influenced by social capital, but the type of influence was dependent on the type of social capital and on the study population. Cognitive social capital, or levels of collective action, was protective against HIV in both men and women. The role of structural social capital, or levels of civic engagement/group participation, on HIV risk was dependent on the type of structural social capital and varied by gender. Microfinance programs and functional group participation were protective for women, while dysfunctional group participation and peer-level support may have increased HIV risk among men. The second manuscript was an original study assessing changes in social capital and HIV risk behavior pre to post immigration among RLIs in South Florida (n=527). HIV risk behavior was assessed through the frequency of vaginal-penile condom use, and the number of sexual partners. It was a longitudinal study using secondary data analysis to assess changes in social capital and HIV risk behavior pre immigration to two years post immigration, and to determine if there was a relationship between the two variables. There was an 8% decrease in total social capital (p ˂ .05). Reporting of ‘Never use’ of condoms in the past 90 days increased in all subcategories (p ˂ .05). Single men had a decrease in number of sexual partners (p ˂ .05). Lower social capital measured on the dimension of ‘friend and other’ was marginally associated with fewer sexual partners. The third manuscript was another original study looking at the association between social capital and substance use among RLIs in South Florida (n=527). Substance use with measured by frequency of hazardous alcoholic drinking, and illicit drug use. It was a longitudinal study of social capital and substance-use from pre to two years post immigration. Post-immigration, social capital, hazardous drinking and illicit drug use decreased (p˂.001). After adjusting for time, compared to males, females were less likely to engage in hazardous drinking (OR=.31, p˂.001), and less likely to engage in illicit drug use (OR=.67, p=.01). Documentation status was a moderator between social capital and illicit drug use. ‘Business’ and ‘Agency’ social capital were associated with changes in illicit drug use for documented immigrants. After adjusting for gender and marital status, on average, documented immigrants with a one-unit increase in ‘business’ social capital were 1.2 times more likely to engage in illicit drug use (p˂.01), and documented immigrants with one-unit increase in ‘agency’ social capital were 38% less likely to engage in illicit drug use (p˂.01). ‘Friend and other’ social capital was associated with a decrease in illicit drug use among undocumented immigrants. After adjusting for gender and marital status, on average, undocumented immigrants with a one-unit increase in ‘friend and other’ social capital were 45% less likely to engage in hazardous drinking and 44% less likely to use illicit drugs (p˂.01, p˂.05). Studying these three domains is relevant because HIV continues to be a public health issue, particularly in Miami-Dade County, which is ranked among other U.S. regions with high rates of HIV/AIDS prevalence. Substance use is associated with HIV risk behavior; in most studies, increased substance use is associated with increased chances of HIV risk behavior. Immigration, which is the hypothesized catalyst for the change in social capital, has an impact on the dynamic of a society. Greater immigration can be burdensome on the host country’s societal resources; however immigrants are also potentially a source of additional skilled labor for the workforce. Therefore, successful adaption of immigrants can have a positive influence on receiving communities. With Florida being a major receiver of immigrants to the U.S, this dissertation attempts to address an important public health issue for South Florida and the U.S. at large.

Religion och ateism i förhållande till livstillfredsställelse och coping : Skiljer sig copingmekanismer och livstillfredsställelse åt mellan religiösa och icke-religiösa? En kvantitativ studie

Syftet med studien var att jämföra grad av coping samt grad av livstillfredsställelse mellan religiösa personer och de som anser sig vara icke troende. För att testa skillnaderna mellan religiösa och ateister gjordes stickprov med data från 30 religiösa och 103 ateister. Mätinstrumentet REI skapades för att mäta graden av tro eller icke tro i avseende att jämföra resultatet mot den trosuppfattning som deltagarna själva hade angivit. Ett Mann–Whitney U test visade att det inte fanns en signifikant skillnad mellan deltagarnas självskattning av tro och resultatet från REI. Resultat från oberoende t-test avseende livstillfredsställelse visar att religiösa och ateister inte signifikant skilde sig åt. Signfikanta skillnader återfanns i oberoende t-test avseende emotionsbaserad, problemfokuserad och dysfunktionell coping. De religiösa och ateistiska grupperna skiljde sig mest i emotionsbaserad coping som hade högst effektstyrka enligt Cohens d (d = 1,39) i jämförelse med effektstyrkan för problemfokuserad och dysfunktionell coping.

Regionen och EU? : Uppfattningar och attityder till EU-relaterade frågor i Västsverige

This thesis explores perceptions and preferences on regional action in EU-related frameworks among regional actors in Western Sweden. Building upon the literature on Europeanisation and the Fusion approach, three dimensions of Europeanisation are clarified and explored– download, upload and crossload – and together with a set of five variables that constitute the Micro Fusion Framework; a comprehensive analytical tool is developed. The thesis analyses the intense debate among the members of West Sweden that took place from 2011 to 2013 that focused on how to functionally organise the regional office in Brussels in order to meet future challenges. Surprisingly, the members eventually decided to terminate their cooperation and close the jointly owned office in Brussels in spite of the fact that it has been widely regarded as successful and effective. Diverging perceptions and preferences is understood in terms of three positions on regional action; a download-, upload- and a coherent oriented position. Finally, the thesis presents the empirical findings and discusses in relation to three fusion scenarios, infusion, defusion and clustered fusion. In terms of Micro Fusion Framework, the dynamics shaping why West Sweden was finally regarded as a dysfunctional arena for regional action are explained by a shift of attention and action among regional actors in Western Sweden that led to pressure for further institutional adaptation in order to meet the demand of how ‘to get the best out of the EU’. Further, this redefinition of how to handle EU-affairs within the upload-oriented position was accompanied by positive attitudes towards the potential to bypass the state and thereby pursue regional priorities directly in Brussels given the compound nature of the EU. In contrast, those regional actors that are found to be more download-oriented often question the benefits of uploading activities in practice and advocate close relations to the state. A coherent oriented position recognises the importance of activities related to both of the vertical dimensions of Europeanisation.

Neurodegeneration and the m-AAA protease: pathogenic cascades in neurons and myelinating cells

The m-AAA protease is a hexameric complex involved in processing of specific substrates and turnover of misfolded polypeptides in the mitochondrial inner membrane. In humans, the m-AAA protease is composed of AFG3L2 and paraplegin. Mutations in AFG3L2 have been implicated in dominant spinocerebellar ataxia (SCA28) and recessive spastic ataxia-neuropathy syndrome (SPAX5). Mutations of SPG7, encoding paraplegin, are linked to hereditary spastic paraplegia. In the mouse, a third subunit AFG3L1 is expressed. Various mouse models recapitulate the phenotype of these neurodegenerative disorders, however, the pathogenic mechanism of neurodegeneration is not completely understood. Here, we studied several mouse models and focused on cell-autonomous role of the m-AAA protease in neurons and myelinating cells. We show that lack of Afg3l2 triggers mitochondrial fragmentation and swelling, tau hyperphosphorylation and pathology in Afg3l2 full-body and forebrain neuron-specific knockout mice. Moreover, deletion of Afg3l2 in adult myelinating cells causes early-onset mitochondrial abnormalities as in the neurons, but the survival of these cells is not affected, which is a contrast to early neuronal death. Despite the fact that myelinating cells have been previously shown to survive respiratory deficiency by glycolysis, total ablation of the m-AAA protease by deleting Afg3l2 in an Afg3l1 null background (DKO), leads to myelinating cell demise and subsequently progressive axonal demyelination. Interestingly, DKO mice show premature hair greying due to loss of melanoblasts. Together, our data demonstrate cell-autonomous survival thresholds to m-AAA protease deficiency, and an essential role of the m-AAA protease to prevent cell death independent from mitochondrial dynamics and the oxidative capacity of the cell. Thus, our findings provide novel insights to the pathogenesis of diseases linked to m-AAA protease deficiency, and also establish valuable mitochondrial dysfunctional mouse models to study other neurodegenerative diseases, such as tauopathies and demyelinating diseases.

Hallazgos ecográficos en la estenosis uretral y su correlación con endoscopia y uretrografía

"Con la implementación estandarizada de la ecografía uretral se pretende tener un efecto directo en el diagnóstico oportuno, no invasivo y sin complicaciones inherentes a la instrumentación del tracto urinario bajo en los pacientes que padecen de estenosis uretral; que finalmente redundará en disminución de costos a corto y largo plazo gracias a la eliminación de estudios innecesarios y procedimientos terapéuticos infructuosos, beneficiando al paciente y al sistema de salud vigente en nuestro medio. Los sujetos con estenosis uretrales complejas podrían ser diagnosticados de manera rápida, sencilla y minimamente invasiva sin importar la localización de la anomalía y su complejidad". (Extracto de la introducción)

Traços desadaptativos da personalidade, sintomas depressivos e afectividade positiva e negativa: Uma amostra com estudantes universitários

Pretendemos estudar quais os traços desadaptativos de personalidade que se relacionam com os sintomas depressivos, a afectividade positiva e negativa, numa amostra de 187 estudantes universitários, entre os 18 e os 43 anos. Calculámos as correlações entre as escalas de padrões de personalidade e as escalas de padrões graves de personalidade do Inventário Multiaxial clínico de Millon II (MCMI-II) com os sintomas depressivos avaliados pela Escala de Depressão do Centro de Estudos Epidemiológicos e com a afectividade positiva e negativa avaliadas pela Escala de Afectividade Positiva e Afectividade Negativa. Realizámos uma análise da regressão múltipla utilizando as escalas de padrões de personalidade do MCMI-II como predictores e o resultado na CES-O, como variável dependente. Obtivemos uma correlação significativa entre os padrões de personalidade borderline, masoquista, esquizotípico, negativista e evitante e paranóide e os sintomas depressivos. A afectividade negativa apresenta-se também positivamente correlacionada com os padrões dependente e esquizóide. A afectividade positiva correlacionou-se significativa e positivamente com os padrões histriónico e narcisista e negativamente com os padrões esquizóide, esquizotípico, negativista, borderline, evitante e masoquista. Na análise de regressão, o padrão borderline prevê a presença de sintomas depressivos e os padrões sádico e dependente também, mas num sentido negativo. /ABSTRACT: We intendend to study wich personality traits relate to depressiva symptoms, and positive and negative affectivity, in a sample of 187 university students, between 18 and 43 years. We did the correlation between the personality patterns scales and the personality patterns of severe personality with the depressive symptoms measured by the Center for Epidemiologic Studies Depression Scale and the positive and negative affectivity measured by the Positive Affect and Negative Affect Shedule. We did a multiple regression analysis using the personality patterns scale of Millon Clinical Multiaxial lnventory (MCMI-II) as predictors and the result of CES-D, as dependent variable. We obtained a significant correlation between the borderline, masochist, schizotypal, negativistic, avoidant and paranoid personality patterns and the depressive symptoms. Negative affectivity relates also positively with dependent and schizoid patterns. Positive affectivity correlated significant and positively with histrionic and narcissistic personality patterns and negatively with schizoid, schizotypal, negativistic, borderline, avoidant and masochist personality patterns. ln the regression analysis, the borderline pattern predicts the presence of depressive symptoms as well as the sadistic and dependent, but in the negative sense.

Modeling Alzheimer disease with iPSCs and mouse model for the identification of risk factors, new targets, and potential therapeutical strategies

Alzheimer's disease (AD) is the most common neurodegenerative disease in elderly. Donepezil is the first-line drug used for AD. In section one, the experimental activity was oriented to evaluate and characterize molecular and cellular mechanisms that contribute to neurodegeneration induced by the Aβ1-42 oligomers (Aβ1-42O) and potential neuroprotective effects of the hybrids feruloyl-donepezil compound called PQM130. The effects of PQM130 were compared to donepezil in a murine AD model, obtained by intracerebroventricular (i.c.v.) injection of Aβ1-42O. The intraperitoneal administration of PQM130 (0.5-1 mg/kg) after i.c.v. Aβ1-42O injection improved learning and memory, protecting mice against spatial cognition decline. Moreover, it reduced oxidative stress, neuroinflammation and neuronal apoptosis, induced cell survival and protein synthesis in mice hippocampus. PQM130 modulated different pathways than donepezil, and it is more effective in counteracting Aβ1-42O damage. The section two of the experimental activity was focused on studying a loss of function variants of ABCA7. GWA studies identified mutations in the ABCA7 gene as a risk factor for AD. The mechanism through which ABCA7 contributes to AD is not clear. ABCA7 regulates lipid metabolism and critically controls phagocytic function. To investigate ABCA7 functions, CRISPR/Cas9 technology was used to engineer human iPSCs and to carry the genetic variant Y622*, which results in a premature stop codon, causing ABCA7 loss-of-function. From iPSCs, astrocytes were generated. This study revealed the effects of ABCA7 loss in astrocytes. ABCA7 Y622* mutation induced dysfunctional endocytic trafficking, impairing Aβ clearance, lipid dysregulation and cell homeostasis disruption, alterations that could contribute to AD. Though further studies are needed to confirm the PQM130 neuroprotective role and ABCA7 function in AD, the provided results showed a better understanding of AD pathophysiology, a new therapeutic approach to treat AD, and illustrated an innovative methodology for studying the disease.

Analyzing urban green adaptation opportunities: concepts, approaches, & strategies for existing neighborhoods

Over the last decades, the growing evidence of human-caused climate change has raised awareness of the consequences of exceeding global temperature by 2˚C. This awareness has led to a contemporary approach to the conceptualization and management of green adaptation policies in spatial planning. This thesis aims to develop a comprehensive methodology for assessing the adaptability of existing neighborhoods to green strategies. The reliability of the proposed method is examined in the cities of Bologna and Imola and proved to be applicable in other geoghraphical locations. This thesis integrates three key themes of conceptual and implementation principles for urban green adaptation. This thesis initially defines methods for narrowing uncertainties in urban planning energy forecasting modeling by exploring the roles of integrated energy planning. The second is by exploring green retrofitting strategies in building, this thesis examines the effects of various energy-saving factors in roofing scenarios including a green roof, rooftop greenhouse, and insolated roof. Lastly, this thesis analyzes green strategies in urban spaces to enhance thermal comfort through facing urban heat exposure related to urban heat island effects. The roles of integrated energy policies and green strategic thinking are discussed to highlight various aspects of green adaptation on the neighborhood scale. This thesis develops approaches by which cities can face the challenges of current green urban planning and connect the conceptual and practical aspects of green spatial planning. Another point that this thesis highlight is that due to the interdependency of individuals and places, it is difficult to assure whether all the adaptation policies on a large scale are enhancing the resiliency of the neighborhood or they are simply shuffling the vulnerability through the individuals and places. Besides, it asserts that neglecting to reflect on these reallocations of the effects generates serious complications, and will result in long-term dysfunctional consequences.

Disorders of arousal: a physiopathological window to explore the mechanisms regulating sleep arousal

Disorders of Arousal (DoA) belong to NREM parasomnias and are characterized by motor and emotional episodes arising from incomplete awakenings from NREM sleep. DoA episodes embody at the same time the double nature of the arousal process, that is preserving sleep as well as respond to sleep perturbations, thus being an ideal model to study sleep arousal. In the first part of this work, we performed a spectral whole scalp EEG analysis exploring the neurophysiologic correlates of the pre-motor onset of the episodes in a large sample of patients with DoA, disclosing the co-existence of both slow and fast EEG frequencies over overlapping areas before DoA episodes, suggesting an alteration of local sleep mechanisms. Episodes of different complexity were preceded by a similar EEG activation, implying that they possibly share a similar pathophysiology. In the second part of this work, we performed a spectral whole scalp EEG analysis comparing the pre-motor onset of the episodes and normal arousals from healthy sleepers, disclosing the persistence of slow frequencies as well as sigma band (expression of sleep spindles) in DoA episodes. Overall, these results might subtend a higher tendence to preserve sleep and a more defective mechanism toward developing a complete arousal in patients with DoA. In the last part of our work, we evaluated 15 patients with DoA with 15 controls in a functional MRI study during wakefulness in addition to a proton magnetic resonance spectroscopy (1H-MRS) focused on cingulate cortex. We disclosed subtle alterations on posterior cingulate cortex as well as an increased connectivity in sensory-motor network, possibly representing a trait-functional feature responsible for the dysfunctional arousal process in DoA patients