Effect of a multimodal exercise program on sleep disturbances and instrumental activities of daily living performance on Parkinson's and Alzheimer's disease patients

Aim: To assess the contribution of a multimodal exercise program on the sleep disturbances (SD) and on the performance of instrumental activities daily living (IADL) in patients with clinical diagnosis of Alzheimer's disease (AD) and Parkinson's disease patients (PD). Methods: A total of 42 consecutive patients (23 training group, 19 control group) with PD and 35 demented patients with AD (19 trained group, 16 control group) were recruited. Participants in both training groups carried out three 1-h sessions per week of a multimodal exercise program for 6 months. The Pfeffer Questionnaire for Instrumental Activities and the Mini-Sleep Questionnaire were used to assess the effects of the program on IADL and SD respectively. Results: Two-way ancova showed interactions in IADL and SD. Significant improvements were observed for these variables in both intervention groups, and maintenance or worsening was observed in control groups. The analysis of effect size showed these improvements. Conclusion: The present study results show that a mild to moderate intensity of multimodal physical exercises carried out on a regular basis over 6 months can contribute to reducing IADL deficits and attenuating SD. © 2013 Japan Geriatrics Society.

In Vitro and In Vivo Activities of Ruthenium(II) Phosphine/Diimine/Picolinate Complexes (SCAR) against Mycobacterium tuberculosis

Rifampicin, discovered more than 50 years ago, represents the last novel class of antibiotics introduced for the first-line treatment of tuberculosis. Drugs in this class form part of a 6-month regimen that is ineffective against MDR and XDR TB, and incompatible with many antiretroviral drugs. Investments in R&D strategies have increased substantially in the last decades. However, the number of new drugs approved by drug regulatory agencies worldwide does not increase correspondingly. Ruthenium complexes (SCAR) have been tested in our laboratory and showed promising activity against Mycobacterium tuberculosis. These complexes showed up to 150 times higher activity against MTB than its organic molecule without the metal (free ligand), with low cytotoxicity and high selectivity. In this study, promising results inspired us to seek a better understanding of the biological activity of these complexes. The in vitro biological results obtained with the SCAR compounds were extremely promising, comparable to or better than those for first-line drugs and drugs in development. Moreover, SCAR 1 and 4, which presented low acute toxicity, were assessed by Ames test, and results demonstrated absence of mutagenicity. © 2013 Pavan et al.

Actividades del sistema de la CEPAL para promover y apoyar la cooperación entre países y regiones en desarrollo = Activities of the ECLAC system to promote and support co-operation among developing countries and regions

Da cuenta de las principales actividades operacionales realizadas por el sistema de la CEPAL desde el 21 periodo de sesiones de la Comision, especialmente en el marco de su resolucion 486(XXI): Cooperacion tecnica y economica entre paises y regiones en desarrollo.

Informe de actividades del Centro Latinoamericano de Demografía (CELADE), 1986-1987 = Report of the activities of the Latin American Demographic Centre (CELADE), 1986-1987

Presenta las actividades agrupadas en tres áreas de trabajo o subprogramas: integración de la población en el desarrollo socioeconómico, información sobre población y su tecnología, y enseñanza y capacitación. En anexo, con cuadros, ofrece un detalle de las misiones de cooperación técnica a los países de la región, los cursos de capacitación y las publicaciones correspondientes al bienio.

Informe de actividades del Centro Latinoamericano de Demografía (CELADE), 1988-1989 = Report of the activities of the Latin American Demographic Centre (CELADE), 1988-1989

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Actividades del sistema de la CEPAL para promover y apoyar la cooperación técnica entre países y regiones en desarrollo = Activities of the ECLAC system to promote and support technical co-operation among developing countries and regions

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Informe de las actividades de la Comisión desde mayo de 1990 = Report of activities of the Commission since May 1990

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Informe de actividades de la Comisión desde abril de 1992 = Report of activities of the Commission since April 1992

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