819 resultados para Rothschild, Thérèse vonRothschild, Thérèse vonThérèseRothschildvonasn1931
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[Rédigé et mis en ordre par Emile Picot] [[Elektronische Ressource]] : Bd. 1
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gehalten im Auftr. der Stifterin von Leopold Stein [[Elektronische Ressource]]
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hrsg. von Ludwig Fort
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hrsg. unter Mitwirkung ... von ... August Schmidt
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Vorbesitzer: Freiherrlich Carl von Rothschild'sche Bibliothek Frankfurt am Main; Akzessionsnummer: x18722; Bemerkung: Maße ohne Passepartout
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Welsch (Projektbearbeiter): Vergleich der gemeinnützigen Aktivitäten des Bankiers Rothschild mit denen des verstorbenen Wiener Industriellen und Philanthropen Herman Tedesco: "... jeder Bedrängte erhielt da eine Unterstützung; den Herrn Baron aber [Rothschild] kann man nur in Geschäftsangelegenheiten sprechen ... Eine Vergrößerung der jährlichen Spenden mit 100.000 fl. Conv. Münze würde diesem Manne [Rothschild] auch jetzt nichts schaden und sehr viel Elend von den Leidenden abwenden"
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BACKGROUND Buruli ulcer (BU) is a necrotizing skin disease most prevalent among West African children. The causative organism, Mycobacterium ulcerans, is sensitive to temperatures above 37°C. We investigated the safety and efficacy of a local heat application device based on phase change material. METHODS In a phase II open label single center noncomparative clinical trial (ISRCTN 72102977) under GCP standards in Cameroon, laboratory confirmed BU patients received up to 8 weeks of heat treatment. We assessed efficacy based on the endpoints 'absence of clinical BU specific features' or 'wound closure' within 6 months ("primary cure"), and 'absence of clinical recurrence within 24 month' ("definite cure"). RESULTS Of 53 patients 51 (96%) had ulcerative disease. 62% were classified as World Health Organization category II, 19% each as category I and III. The average lesion size was 45 cm(2). Within 6 months after completion of heat treatment 92.4% (49 of 53, 95% confidence interval [CI], 81.8% to 98.0%) achieved cure of their primary lesion. At 24 months follow-up 83.7% (41 of 49, 95% CI, 70.3% to 92.7%) of patients with primary cure remained free of recurrence. Heat treatment was well tolerated; adverse effects were occasional mild local skin reactions. CONCLUSIONS Local thermotherapy is a highly effective, simple, cheap and safe treatment for M. ulcerans disease. It has in particular potential as home-based remedy for BU suspicious lesions at community level where laboratory confirmation is not available. CLINICAL TRIALS REGISTRATION ISRCT 72102977.