Síntese de tetra-hidropiridinas por meio de reações multicomponentes

Multicomponent Reactions are defined as reactions between three or more reagents in a single reaction step in the same reaction vial, forming a product that includes the majority of atoms and structural characteristics of the reagents. Thus these reactions save time and energy. One of the ways to improve the yield and reaction time of a multicomponent reaction is to use different catalysts, an example of catalyst that shows great potential and has been studied in recent years is the molecular iodine is known to be a Lewis acid with high catalytic power. The functionalized piperidines, also known as tetrahydropyridines, are alkaloids that have pharmacological potential, this is due to the piperidine ring present in many natural product structures with muscarinic activity, nicotine, analgesic, antipsychotic, anti-proliferative, among others. In this paper we describe studies about on the application of molecular iodine (I2) in the multicomponent reaction between aniline derivatives, benzaldehyde and β-ketoester (methyl acetoacetate) for the synthesis of functionalized piperidines and the synthesis of a corresponding piperidone by acid hydrolysis. Data analysis allowed us to demonstrate the efficacy of molecular iodine in the synthesis of functionalized piperidines, obtaining results with yields 44-87% and short reaction time of 8 to 24 hours, and the efficacy of acid hydrolysis of enamine in the structure of the tetrahydropyridine derivative in a yield of 81%

Estudos sobre as defasagens de Prometeu e Pandora

Pós-graduação em Física - FEG

Complexos heterobilantanídicos luminescentes sob excitação UV e raios X

Pós-graduação em Química - IQ

Atributos físicos e químicos de um argissolo sob diferentes Sistemas de Uso da Terra (SUTs)

Pós-graduação em Agronomia (Ciência do Solo) - FCAV

Codificação de canais em sistemas de comunicação sem fio baseado em reticulados

Pós-graduação em Engenharia Elétrica - FEIS

Pimenta pseudocaryophyllus (Gomes) L. R. Landrum (Myrtaceae): stem and leaf anatomy of a medicinal plant

Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)

Capsular tension ring alone and associated with acrylic foldable intraocular lens in posterior capsular opacification after phacoemulsification in dogs

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação da construção e operação de técnicas compensatórias de drenagem urbana: o transporte de finos, a capacidade de infiltração, a taxa de infiltração real do solo e a permeabilidade da manta geotêxtil

This work aimed to evaluate some aspects of construction and operation of full-scale best management practices and their effects on infiltration loading rate. Two systems were studied: i) filter-swale-trench (FST) and ii) infiltration well (IW). In these units, field essays and full-scale measurements were made in order to assess the soil permeability. Further, the fine particles transportation and the geotextile blanket permeability were determined before and after operation. The results pointed out that there were soil transportation to inside the FST and IW systems, despite of the installed protections, and that these material were responsible for diminishing the geotextile (reduction from 30 to 90% for FST and 40 to 70% for IW) and the full-scale infiltration loading rates (varying from 4,7 x 10-6 to 10-5 m.s-1).

Disposição construtiva aplicada em contenção ortodôntica

Disposição construtiva aplicada em contenção ortodôntica. Patente de modelo de utilidade para uma disposição construtiva aplicada em contenção ortodôntica, compreendida por ser do tipo 3x3, com encaixe do tipo "macho-fêmea", sendo que na base da "fêmea" (1) são procedidas retenções (2) mecânicas para fixação por meio de colagem na face lingual dos caninos (3) inferiores, com resina composta, de modo que no interior da "fêmea" (1) é provido um orifício (4) para o encaixe do "macho" (5) e, no centro da cavidade é provido um anel (6) elástico que se encaixa precisamente numa canaleta feita no pino (7) de encaixe do "macho" (5), sendo que, na extremidade dos "machos" (5) podem existir prolongamentos (8) metálicos para retenção de acrílico (9) ou então meios de encaixe para soldagem de um fio metálico (10) espesso, que contorna a face lingual dos dentes (11); inferiores anteriores, de modo que, quando se optar pela retenção em acrilico (9), um fio metálico (10) mais delgado é soldado no terminal de encaixe do "macho" (5) e logo após, o fio (10) e o terminal são recobertos por acrilico (9), sendo que os "machos" (5) poderão ter angulações nos braços (12) de encaixes.

Degradação química e fotoquímica do organofosforado paraoxona

Pós-graduação em Química - IBILCE

Torres de extensões abelianas de grau primo ímpar não ramificado

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Síntese de aminochalconas e análogos arílicos como agentes antivirais, antifúngicos e inibidores de mieloperoxidase

Pós-graduação em Química - IBILCE

Anéis de inteiros de corpos de números e aplicações

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fatores biomecânicos relevantes na seleção dos grampos em próteses parciais removíveis com extremo livre: estudo clínico

The free-end removable partial dentures (RPD) shows a complicated and peculiar biomechanical behavior that impose high occlusion forces to the abutment teeth. By this way, the aim of this study was to evaluate the several factors that influence the clasps indication to free-end RPD. It was analysed 84 designed and planned study models of 71 patients, involving 130 clasps near-by a free-end; followed by clinical and radiographical informations. It was observed that bar clasps (“T”, “Tmod”, “i”) were used in 88.46% of abutment teeth. In the others (11.55%), it was used simple, combinated or ring circumferential clasps, and MDL. In abutment teeth with high equator line the “i” clasps were predominant (48.48%). The “Tmod” clasps were predominant in abutment teeth with low equator line (50%) or in middle third (51.35%) and “T” clasps were predominant in inclined equators with mesio-buccal (56.52%) or disto-buccal (66.66%) retention. In the posterior abutment teeth, it was prevalent the distal rest (63.52%) and embracing to the adjacent tooth. Some others factors like long clinical crown (5.38%), wrong position of abutment teeth (4.61%), aesthetics (3.07%), retention in alveolar ridge (2.3%), fragility of abutment teeth (1.53%), short clinical crown (0.76%) and short space to the clasp (0.76%) influenced directly during the clasps selection. Factors like mobility of abutment teeth, height of muscular insertions, depth of buccal fornix and antagonist arch acted like secondary factors. After the informations analysis it may be concluded that the bar clasps with distal rest and embracing to the adjacent tooth were the most indicated to free-end RPD

Isolamento de cepas bacterianas degradadoras de hidrocarbonetos aromáticos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)