Deux sonates et La Coquette pour forte piano [Música notada] : oeuvre VI

Encuadernado con: A favourite concerto for the piano-forte or harpsichord with accompaniments for two violins and a violoncello ; Trois trios pour le clavecin ou piano-forte avec violon [et] violoncelle : oeuvre 41. Liv. I y Liv. II ; Haydn's celebrated overture composed for & performed at Mr. Salomon's concert Hanover-Square : adapted for the piano-forte, with an accompaniment for a violin & violoncello ad libitum. N. 2 y N. 3 ; [Sonatas] ; Sonata for the pianoforte or harpsichord : op. 66

A favourite concerto for the piano-forte or harpsichord with accompaniments for two violins and a violoncello [Música notada]

Hay un ejemplar encuadernado con: Deux sonates et La Coquette pour forte piano (XVIII/2815)

Otro título: Tres fugas a 4

Número 312 en el catálogo de Vicente Galbis e Hilari García, bajo el nombre de "Tres fugas a 4"

Fuga, sobre un motivo de "Un Ballo in Maschera" [Manuscrito]

Número 300 en el catálogo de Vicente Galbis e Hilari García

Cuarteto 1 [Manuscrito]

Número 295 en el catálogo de Vicente Galbis e Hilari García

Cuarteto 2 [Manuscrito]

Número 296 en el catálogo de Vicente Galbis e Hilari García

Cuarteto 2º [Manuscrito]

Número 296 en el catálogo de Vicente Galbis e Hilari García

Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes

The telomeric G-rich single-stranded DNA can adopt in vitro an intramolecular quadruplex structure, which has been shown to directly inhibit telomerase activity. The reactivation of this enzyme in immortalized and most cancer cells suggests that telomerase is a relevant target in oncology, and telomerase inhibitors have been proposed as new potential anticancer agents. In this paper, we describe ethidium derivatives that stabilize G-quadruplexes. These molecules were shown to increase the melting temperature of an intramolecular quadruplex structure, as shown by fluorescence and absorbance measurements, and to facilitate the formation of intermolecular quadruplex structures. In addition, these molecules may be used to reveal the formation of multi-stranded DNA structures by standard fluorescence imaging, and therefore become fluorescent probes of quadruplex structures. This recognition was associated with telomerase inhibition in vitro: these derivatives showed a potent anti-telomerase activity, with IC50 values of 18–100 nM in a standard TRAP assay.