O trabalho como estratégia de atenção em saúde mental: cartografias do conceito Trabalho nas políticas públicas de saúde

Pós-graduação em Psicologia - FCLAS

Effects of the administration of pentoxifylline and prednisolone on the evolution of portal fibrogenesis secondary to biliary obstruction in growing animals: immunohistochemical analysis of the expression of TGF-BETA; and VEGF

OBJECTIVE: During the neonatal and infancy periods, some chronic liver diseases may lead to progressive hepatic fibrosis, which is a condition that can ultimately result in the loss of organ function and severe portal hypertension necessitating hepatic transplantation. In a previous report, pharmacological interventions were demonstrated to modulate hepatic fibrosis induced by bile duct ligation in young rats. The administration of pentoxifylline or prednisolone, or the combination of both, resulted in reduced fibrogenesis in portal spaces. The objectives of the present study were to evaluate the expression of transforming growth factor beta and vascular endothelial growth factor after bile duct ligation in young rats and to assess the effect of those same drugs on cytokine expression. METHODS: In this experimental study, 80 young rats (21 or 22 days old) were submitted either to laparotomy and common bile duct ligation or to sham surgery. The animals were allocated into four groups according to surgical procedure, and the following treatments were administered: (1) common bile duct ligation + distilled water, (2) sham surgery + distilled water, (3) common bile duct ligation + pentoxifylline, or (4) common bile duct ligation + prednisolone. After 30 days, a hepatic fragment was collected from each animal for immunohistochemical analysis using monoclonal antibodies against transforming growth factor beta and vascular endothelial growth factor. Digital morphometric and statistical analyses were performed. RESULTS: The administration of pentoxifylline reduced the transforming growth factor beta-marked area and the amount of transforming growth factor beta expressed in liver tissue. This effect was not observed after the administration of prednisolone. There was a significant reduction in vascular endothelial growth factor expression after the administration of either drug compared with the non-treatment group. CONCLUSIONS: The administration of pentoxifylline to cholestatic young rats resulted in the diminished expression of transforming growth factor beta and vascular endothelial growth factor in liver tissue. The administration of steroids resulted in the diminished expression of vascular endothelial growth factor only. These pathways may be involved in hepatic fibrogenesis in young rats submitted to bile duct ligation and exposed to pentoxifylline or prednisolone.

Effect of the Single or Combined Administration of Cocaine and Testosterone on Cardiovascular Function and Baroreflex Activity in Unanesthetized Rats

Abuse of cocaine and androgenic-anabolic steroids has become a serious public health problem. Despite reports of an increase in the incidence of simultaneous illicit use of these substances, potential toxic interactions between cocaine and androgenic-anabolic steroids in the cardiovascular system are unknown. In the present study, we investigated the effect of single or combined administration of testosterone and cocaine for 1 or 10 consecutive days on basal cardiovascular parameters, baroreflex activity, and hemodynamic responses to vasoactive agents in unanesthetized rats. Ten-day combined administration of testosterone and cocaine increased baseline arterial pressure. Changes in arterial pressure were associated with altered baroreflex activity and impairment of both hypotensive response to intravenous sodium nitroprusside and pressor effect of intravenous phenylephrine. Chronic single administration of either testosterone or cocaine did not affect baseline arterial pressure. However, testosterone-treated animals presented rest bradycardia, cardiac hypertrophy, alterations in baroreflex activity, and enhanced response to sodium nitroprusside. Repeated administration of cocaine affected baroreflex activity and impaired vascular responsiveness to both sodium nitroprusside and phenylephrine. One-day single or combined administration of the drugs did not affect any parameter investigated. In conclusion, the present results suggest a potential interaction between toxic effects of cocaine and testosterone on the cardiovascular activity. Changes in baseline arterial pressure after combined administration of these 2 drugs may result from alterations in baroreflex activity and impairment of vascular responsiveness to vasoactive agents.

Interferencias políticas e interinstitucionales al proyecto de centralización de la administración sanitaria nacional (1943-1945)

El objetivo de este trabajo es profundizar en las razones de los cambios que se operan en la estructura administrativa sanitaria nacional entre 1943 y 1945. Si bien la creación de la Dirección Nacional de Salud y Acción Social en 1943 responde a una larga demanda de los círculos académicos de centralización administrativa y de unificación de las funciones sanitarias y asistenciales, la corta duración del proyecto (menos de un año) expone consideraciones por afuera de la lógica administrativa. Analizamos aquellas que se vinculan con la complicada relación entre la repartición nacional con los gobiernos provinciales y las organizaciones de beneficencia, con la injerencia del gremialismo médico en el delineamiento de las políticas sanitarias y con el ascendiente de Juan Domingo Perón desde la Secretaría de Trabajo y Bienestar Social en la monopolización de la asistencia social como capital político.

Interferencias políticas e interinstitucionales al proyecto de centralización de la administración sanitaria nacional (1943-1945)

El objetivo de este trabajo es profundizar en las razones de los cambios que se operan en la estructura administrativa sanitaria nacional entre 1943 y 1945. Si bien la creación de la Dirección Nacional de Salud y Acción Social en 1943 responde a una larga demanda de los círculos académicos de centralización administrativa y de unificación de las funciones sanitarias y asistenciales, la corta duración del proyecto (menos de un año) expone consideraciones por afuera de la lógica administrativa. Analizamos aquellas que se vinculan con la complicada relación entre la repartición nacional con los gobiernos provinciales y las organizaciones de beneficencia, con la injerencia del gremialismo médico en el delineamiento de las políticas sanitarias y con el ascendiente de Juan Domingo Perón desde la Secretaría de Trabajo y Bienestar Social en la monopolización de la asistencia social como capital político.

Interferencias políticas e interinstitucionales al proyecto de centralización de la administración sanitaria nacional (1943-1945)

El objetivo de este trabajo es profundizar en las razones de los cambios que se operan en la estructura administrativa sanitaria nacional entre 1943 y 1945. Si bien la creación de la Dirección Nacional de Salud y Acción Social en 1943 responde a una larga demanda de los círculos académicos de centralización administrativa y de unificación de las funciones sanitarias y asistenciales, la corta duración del proyecto (menos de un año) expone consideraciones por afuera de la lógica administrativa. Analizamos aquellas que se vinculan con la complicada relación entre la repartición nacional con los gobiernos provinciales y las organizaciones de beneficencia, con la injerencia del gremialismo médico en el delineamiento de las políticas sanitarias y con el ascendiente de Juan Domingo Perón desde la Secretaría de Trabajo y Bienestar Social en la monopolización de la asistencia social como capital político.

Plano general de la ciudad de Murviedro [ [Material gráfico]= Plan géneral de la ville de Murviedro et de l'antique Sagonte = General plan of the city of Murviedro and of the antique Sagunro

Escala expresada en pies castellanos.

Assessing priorities for allocation of donor liver grafts: survey of public and clinicians

Objectives: To compare the priorities of the general public, family doctors, and gastroenterologists in allocating donor livers to potential recipients of liver allograft.

Disclosure of Leniency Materials: A Bridge between Public and Private Enforcement of Antitrust Law. Research Paper in Law 08/2013, December

The disclosure of leniency materials held by competition authorities has recently been under the spot. On the one hand, these documents could greatly help cartel victims to prove the damage and the causation link when filing damage actions against cartelists. On the other hand, future cartelists could be deterred from applying for leniency since damage actions could be brought as a result of the information submitted by themselves. Neither the current legislation nor the case law have attained yet to sufficiently clarify how to deal with this clash of interests. Our approach obviously attempts to strike a balance between both interests. But not only that. We see the current debate as a great opportunity to boost the private enforcement of antitrust law through the positive spillovers of leniency programmes. We hence propose to build a bridge between the public and the private enforcement by enabling a partial disclosure of the documents.

Policy recommendations for the new European Commission: priorities for stabilising EMU. EPC Discussion Paper, 30 September 2014

The euro area crisis exposed substantial structural flaws in the currency area’s architecture. Addressing these flaws this discussion paper explores the ways in which the European Institutions can re-evaluate and overcome challenges for a more positive European future. To do this, Janis A. Emmanouilidis, Jan David Schneider, and Fabian Zuleeg recommend that the coming European Commission should develop a new framework to assess the real returns to growth of public and social investment, which could open the path for more flexibility on deficits in future. In close coordination with the European Parliament, the Commission should also review the Country Specific Recommendations with a stronger focus on a smaller number of key priorities for each country. The construction of a fiscal capacity should be made a priority in the new political cycle to resolve the absence of a mechanism to provide effective ex ante fiscal risk sharing in the Eurozone. Furthermore, to boost growth, there is a need to encourage private, public and social investment through a European Investment Programme (EIP) in the short term. Finally, the Commission should ensure that the implementation of an EIP is compatible with the long term goals of a fiscal capacity.

Convention revising the General Act of Berlin, February 26, 1885, and the General Act and Declaration of Brussels, July 2, 1890 : signed at Saint-Germain-en-Laye, September 10, 1919.

"Presented to Parliament by Command of His Majesty."

A report on public and community health personnel : prepared for the Committee on Interstate and Foreign Commerce, House of Representatives and the Committee on Labor and Human Resources, United States Senate, as required by section 793 of the Public health service act

"December 7, 1979."

Annual report of the Postmaster General : hearing before the International Security, Proliferation, and Federal Services Subcommittee of the Committee on Governmental Affairs, United States Senate, One Hundred Sixth Congress, first session, September 16, 1999.

Shipping list no.: 2000-0270-P.

The annual report of the Postmaster General : hearing before the International Security, Proliferation, and Federal Services Subcommittee of the Committee on Governmental Affairs, United States Senate, One Hundred Sixth Congress, second session, July 13, 2000.

Shipping list no.: 2001-0042-P.

Public and private coordination needed if auto repair problems are to be reduced.

Mode of access: Internet.