Els primers historiadors de la ciutat: Jeroni Pau i Dionís Jeroni Jorba

Text de la conferència pronunciada per Mariàngela Vilallonga on es fa un repàs biogràfic dels historiadors Jeroni Pau i Dionís Jeroni Jorba, així com de la seva obra, és a dir, els primers textos que tenien a Barcelona com a matèria d’estudi

Historia de la alimentación parenteral; primera lección Jesús Culebras

Artículo histórico. Texto de la “Primera lección Jesús Culebras” dictada en el XXV Congreso Nacional de SENPE, Badajoz, 11-14 de mayo de 2010.

Procedures for monitoring recombinant erythropoietin and analogs in doping.

Hemoglobin concentration is one of the principal factors of aerobic power and, consequently, of performance in many types of physical activities. The use of recombinant human erythropoietin is, therefore, particularly powerful for improving the physical performances of patients, and, more generally, improving their quality of life. This article discusses procedures for monitoring recombinant erythropoietin and its analogues in doping for athletic performance.

NKT cells: In the beginning...

Invariant natural killer T (iNKT) cells as we know them today are a unique subset of mature T cells co-expressing a semi-invariant Valpha14/Vbeta8 TCR and surface markers characteristic of NK cells. The semi-invariant TCR on iNKT cells recognizes glycolipids bound to monomorphic CD1d molecules, leading to rapid cytokine production. The purpose of this historical perspective is to describe how a series of seemingly unrelated findings in the late 1980s and early 1990s crystallized in the discovery of iNKT cells. The story is told from a personal viewpoint, with a particular effort to place both breakthroughs and misinterpretations in the context of their era.

To Monty Kier, a friendly tribute.

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.

La crampe du musicien. A propos de la maladie de Robert Schumann [The mucisian's cramp. About the illness of Robert Schumann].

The musicians are seen in daily neurological practice facing various problems sometimes simple such as skeletal or tendon pain or even compression of a nerve trunk and sometimes more complicated such as focal dystonia. Dystonia often has a dramatic impact on the career of a musician given the complexity of the clinical and therapeutic approach and the results are often disappointing. The history of the German Romantic composer Robert Schumann illustrates this reality; through his story a discussion of both the different pathophysiological hypotheses responsible for focal dystonia, a disorder of brain plasticity, and of the multimodal therapeutic approaches, revisited in the light of neurophysiological findings will be described.

Història urbana de Girona: el monar reial del Mercadal a Girona

De l'any 1015 consta l'existència del rec comtal, segons escriptura atorgada pel comte Ramon Borrell i per llur esposa, Ermessenda, que varen fer donació a la Seu de Santa Maria, el dia 19 de juny, de quatre mujades de terra situades prop del Mercadal iuxta urbem Gerundensis in ipso plano super ipsum Mercadalem. Les dites terres afrontaven de occiduo in ipso rege comitale i a migdia amb el riu Güell. Aquest fet permet considerar que el rec comtal feia possible, ja al segle XI, la instal·lació del Monar comtal amb llurs molins

Sobre la identitat dels Matiners a les comarques del N.E. de Catalunya

This study attempts to throw some light on the identity of the Matiners of the regions of north-eastern Catalonia by analizing a notebook which was a register of rebels. This notebook gives the age, geographical origin and profession of the rebels. The War of the matiners (1846-49) was a Catalan rebellion framed within the context of popular opposition to the regime of the moderates, and in the midst of a general crisis. Themen who formed the groups of ((trabucaires)) were particulary young (the problemof recriting must not be forgotten), and came from the country, the crafts, and industry, and were militarized above all in the interior regions

El poble d' Ollers i el veïnat d' Espàsens, a final dels segle XVIII

Article sobre l' estructura social del poble d' Ollers i el veïnat d' Espàsens a finals dels segle XVIII

Hypertension and microvascular remodelling

In the present review, microvascular remodelling refers to alterations in the structure of resistance vessels contributing to elevated systemic vascular resistance in hypertension. We start with some historical aspects, underscoring the importance of Folkow's contribution made half a century ago. We then move to some basic concepts on the biomechanics of blood vessels, and explicit the definitions proposed by Mulvany for specific forms of remodelling, especially inward eutrophic and inward hypertrophic. The available evidence for the existence of remodelled resistance vessels in hypertension comes next, with relatively more weight given to human, in comparison with animal data. Mechanisms are discussed. The impact of antihypertensive drug treatment on remodelling is described, again with emphasis on human data. Some details are given on the three studies to date which point to remodelling of subcutaneous resistance arteries as an independent predictor of cardiovascular risk in hypertensive patients. We terminate by considering the potential role of remodelling in the pathogenesis of end-organ damage and in the perpetuation of hypertension.

The Speed of the Financial Revolution: Evidence from Hoare’s Bank

Finance is important for development, yet the onset of modern economic growth in Britain lagged the British financial revolution by over a century. We present evidence from a new West-End London private bank to explain this delay. Hoare’s Bank loaned primarily to a highly select and well-born clientele, although it did not discriminate against “unknown” borrowers in the early 18th century. It could not extend credit more generally because of government restrictions (usury limits) and policies (frequent wars). Britain’s financial development could have aided growth substantially, had it not been for the rigidities and turmoil introduced by government interference.

Federico II de Prusia : el rey flautista

En un momento histórico en el que las tendencias musicales en Europa estaban a medio camino entre el Barroco y el Clasicismo, confluyeron en la corte de Federico el Grande una serie de músicos que trabajaron para el rey prusiano y que compusieron una gran cantidad de música para flauta, instrumento que él tocaba. La actividad musical del Berlín de esos años se convirtió así en relevante para el mundo flautístico. Profundizaremos en este trabajo en la figura del monarca, en la relación de éste con sus músicos y en las características principales de la música de la segunda mitad del siglo XVIII.

Els baixonets a Catalunya : una aproximació organològica, funcional i del repertori : el fons musical de Canet de Mar

Aquest treball fa un estudi dels baixonets a Catalunya des de les perspectives organològica, funcional i del repertori. A partir de les informacions aportades pels instruments originals, pels tractats i per estudis especialitats, es defineixen una tipologia instrumental pròpiament hispànica, i unes funcions principalment relacionades amb la música vocal religiosa de mitjans del segle XVI a mitjans del segle XVIII. Posteriorment, es realitza un estudi de la música amb baixonet a la localitat de Canet de Mar. A partir del treball de camp al seu arxiu parroquial, es compilen vuit obres específiques per a baixonet, se'n transcriuen alguns manuscrits, i se'n defineixen els principals aspectes formals i funcionals. El cas de Canet de Mar es pot considerar com un exemple més o menys representatiu de la pràctica instrumental i del repertori específic del baixonet a Catalunya a finals del segle XVII i començaments del segle XVIII.