Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control.

Valoración de pacientes tratados con hemodiálisis según la Ley de Promoción de la Autonomía Personal y Atención a las personas en situación de dependencia

La valoración del grado de dependencia de los pacientes en diálisis ha sido objeto de interés como indicador clínico y organizativo. El objetivo del estudio es conocer el grado de dependencia que presentan las personas sometidas a tratamiento con diálisis en Catalunya, según los criterios de la Ley sobre Promoción de la Autonomía Personal y Atención a las personas en situación de dependencia. Se ha realizado un estudio descriptivo transversal en 42 centros de Cataluña sobre el grado de dependencia de los pacientes en hemodiálisis. La recogida de datos se hizo mediante una encuesta basada en el baremo de la Ley más datos sociodemográfico y características del tratamiento. De los pacientes que componían la población renal de Cataluña fueron considerados por los profesionales sanitarios con algún grado de dependencia 806, de ellos 425 eran hombres y 381 mujeres; un 61% tienen edades superiores a 70 años. El 53% viven en pareja y el 80,1% tenían uno o más hijos. El 77,4% de los pacientes habían sido trabajadores no cualifi cados, y el 65,4% dijeron no tener estudios. Se consideraron no dependientes 137 pacientes, con dependencia moderada 350, con dependencia

Recueil de traités cabbalistiques

) דף 1א-72א: ג’קטילה, יוסף בן אברהם: שערי צדק. ‬ ‫ 2) דף 72ב-85ב: יעקב בן יעקב הכהן: פרוש מרכבת יחזקאל. ‬ ‫ 3) דף 89א-97ב: יוסף הבא משושן הבירה (מחבר משוער): פרוש עשר ספירות. ‬ ‫ 4) דף 97ב-100ב: ספר התמונה. ‬ ‫ 5) דף 100ב-108א: סוד דרכי הניקוד. ‬ ‫ 6) דף 108א-112ב: פרוש עשר ספירות. ‬ ‫ 7) דף 112א-117א: סודות וטעמים. ‬ ‫ 8) דף 121א-125ב: יצחק בן שמואל מעכו: מאירת עינים (ההתחלה). ‬ ‫ 9) דף 131א-140א: מוטוט, שמואל בן סעדיה אבן: משובב נתיבות. ‬ ‫ 10) דף 141א-166א: פרוש מערכת האלהות. ‬

Social network architecture and the maintenance of deleterious cultural traits.

How have changes in communications technology affected the way that misinformation spreads through a population and persists? To what extent do differences in the architecture of social networks affect the spread of misinformation, relative to the rates and rules by which individuals transmit or eliminate different pieces of information (cultural traits)? Here, we use analytical models and individual-based simulations to study how a 'cultural load' of misinformation can be maintained in a population under a balance between social transmission and selective elimination of cultural traits with low intrinsic value. While considerable research has explored how network architecture affects percolation processes, we find that the relative rates at which individuals transmit or eliminate traits can have much more profound impacts on the cultural load than differences in network architecture. In particular, the cultural load is insensitive to correlations between an individual's network degree and rate of elimination when these quantities vary among individuals. Taken together, these results suggest that changes in communications technology may have influenced cultural evolution more strongly through changes in the amount of information flow, rather than the details of who is connected to whom.

El secreto profesional y la protección de datos de carácter personal

El secreto profesional es un elemento de obligado cumplimiento para los profesionales de la salud, entre ellos la matrona. El deber de guardar secreto permite a las mujeres y a sus familias mantener la intimidad personal, y a los profesionales conocer datos, situaciones y sucesos imprescindibles para la asistencia sanitaria. A las matronas, por nuestro ámbito profesional, se nos confían datos referentes a la salud y a la sexualidad de la mujer, entre otros. La protección de estos datos, su custodia, la elaboración de la historia clínica como elemento fundamental para la asistencia continuada y como justificador del buen hacer profesional de la matrona están regulados jurídicamente y tienen, en la actualidad, gran repercusión legal.

The influence of environmental spatial structure on the life history traits and diversity of species in a metacommunity

Several models have been proposed to understand how so many species can coexist in ecosystems. Despite evidence showing that natural habitats are often patchy and fragmented, these models rarely take into account environmental spatial structure. In this study we investigated the influence of spatial structure in habitat and disturbance regime upon species' traits and species' coexistence in a metacommunity. We used a population-based model to simulate competing species in spatially explicit landscapes. The species traits we focused on were dispersal ability, competitiveness, reproductive investment and survival rate. Communities were characterized by their species richness and by the four life-history traits averaged over all the surviving species. Our results show that spatial structure and disturbance have a strong influence on the equilibrium life-history traits within a metacommunity. In the absence of disturbance, spatially structured landscapes favour species investing more in reproduction, but less in dispersal and survival. However, this influence is strongly dependent on the disturbance rate, pointing to an important interaction between spatial structure and disturbance. This interaction also plays a role in species coexistence. While spatial structure tends to reduce diversity in the absence of disturbance, the tendency is reversed when disturbance occurs. In conclusion, the spatial structure of communities is an important determinant of their diversity and characteristic traits. These traits are likely to influence important ecological properties such as resistance to invasion or response to climate change, which in turn will determine the fate of ecosystems facing the current global ecological crisis.

El secreto profesional y la protección de datos de carácter personal

El secreto profesional es un elemento de obligado cumplimiento para los profesionales de la salud, entre ellos la matrona. El deber de guardar secreto permite a las mujeres y a sus familias mantener la intimidad personal, y a los profesionales conocer datos, situaciones y sucesos imprescindibles para la asistencia sanitaria. A las matronas, por nuestro ámbito profesional, se nos confían datos referentes a la salud y a la sexualidad de la mujer, entre otros. La protección de estos datos, su custodia, la elaboración de la historia clínica como elemento fundamental para la asistencia continuada y como justificador del buen hacer profesional de la matrona están regulados jurídicamente y tienen, en la actualidad, gran repercusión legal.

Adaptación psicosocial en niños adoptados internacionalmente: percepción personal y parental

Objetivo: Evaluar el nivel de adaptación psicosocial en la mediana infancia en ni nos adoptados internacionalmente en Espa na. Material y métodos: Ciento un menores adoptados internacionalmente (67% ni nas), de entre 8 y 12 a nos, y sus respectivos padres adoptivos (97 madres y 67 padres) completaron el Behavior Assessment System for Children (BASC). Se realizaron análisis descriptivos y de comparación de medias (t de Student y Anova) para examinar el efecto de las variables sexo, edad de adopción, edad actual y área de origen en las escalas y dimensiones globales del BASC para cada informante, y se efectuaron análisis de regresión lineal múltiple para conocer su valor predictivo. El acuerdo entre madres y padres se calculó mediante el coeficiente de correlación intraclase (CCI). Los porcentajes de menores en el rango normal y con sintomatología en las dimensiones globales se contrastaron con los teóricos mediante la prueba de la chi al cuadrado. Resultados: Se constata que los ni nos están en general bien adaptados, independientemente del informante. Existen diferencias adaptativas dentro de la normalidad según el área de origen,sexo y edad actual del los ni nos. El CCI presenta un intervalo entre 0,46 (satisfactorio) y 0,84 (excelente). En comparación con el grupo normativo, un mayor porcentaje de ni nos presenta desajuste escolar (24,8%; informado por los ni nos), problemas externalizados (el 27,8 y el 28,3%, informados por las madres y los padres, respectivamente) y dificultades comportamentales y adaptativas (el 28,4 y el 29,9%, respectivamente; informadas por los padres). Conclusiones: Entorno a un 25% de menores adoptados internacionalmente presenta dificultades en áreas adaptativas básicas, identificadas con claridad mediante el uso del BASC, que deben ser atendidas desde un enfoque psicológico y paidológico.

Nitrogen fertilization impact on agronomic traits of maize hybrids released at different decades

Genetic selection of maize hybrids is often conducted using high N rates during the breeding cycle. This procedure may either lead to the release of genotypes that present nitrogen luxury consumption or require a stronger N input to accomplish their yield potential. This work was carried out to evaluate the effects of N rates on grain yield and N use efficiency of hybrids cultivated in different decades in Southern Brazil. The trial was performed in Lages, Santa Catarina State. A split plot design was used. Hybrids Ag 12, Ag 28, Ag 303 and Ag 9012, released during the 60's, 70's, 80's and 90's, respectively, were evaluated in the main plots. Nitrogen rates equivalent to 0, 50, 100 and 200 kg ha-1 were side-dressed in the split-plots when each hybrid had six fully expanded leaves. Modern-day hybrid Ag 9012 had higher grain yield than hybrids of earlier eras, regardless of N rates. Under high doses of N, the older hybrids Ag 12 and Ag 28 took up more N and presented higher values of shoot dry matter at flowering than Ag 9012. Nonetheless, they set less grains per ear which contributed to decrease their grain yield and N use efficiency.

Neutral and selection-driven decay of sexual traits in asexual stick insects.

Environmental shifts and lifestyle changes may result in formerly adaptive traits becoming non-functional or maladaptive. The subsequent decay of such traits highlights the importance of natural selection for adaptations, yet its causes have rarely been investigated. To study the fate of formerly adaptive traits after lifestyle changes, we evaluated sexual traits in five independently derived asexual lineages, including traits that are specific to males and therefore not exposed to selection. At least four of the asexual lineages retained the capacity to produce males that display normal courtship behaviours and are able to fertilize eggs of females from related sexual species. The maintenance of male traits may stem from pleiotropy, or from these traits only regressing via drift, which may require millions of years to generate phenotypic effects. By contrast, we found parallel decay of sexual traits in females. Asexual females produced altered airborne and contact signals, had modified sperm storage organs, and lost the ability to fertilize their eggs, impeding reversals to sexual reproduction. Female sexual traits were decayed even in recently derived asexuals, suggesting that trait changes following the evolution of asexuality, when they occur, proceed rapidly and are driven by selective processes rather than drift.

Biochemical traits useful for the determination of genetic variation in a natural population of Myracrodruon urundeuva

The objectives of this work were to analyze seeds from 20 trees of aroeira (Myracrodruon urundeuva Fr. All.) of a natural population located in the region of Selvíria, State of Mato Grosso do Sul, Brazil, in order to evaluate their protein, lipid and carbohydrate contents, and to estimate their genetic variation. A completely randomized experimental design consisting of 20 treatments (families) was set up, with two replications. Four types of proteins were detected: albumin (35.0 to 107.3 mg/g seed), globulin (3.4 to 9.3 mg/g), prolamin (60.0 to 135.2 mg/g) and glutelin (118.0 to 286.0 mg/g). The lipid content varied between 200 and 334 mg/g seed. The total sugars also varied (26.5 to 46.3 mg/g seed), with a predominance of polyols (arabinitol, mannitol, glucitol and xylitol). The main monosaccharides detected were glucose and arabinose. Total hydrolysis of the sugars indicated the presence of neutral arabinan and xylan oligosaccharides. The starch content varied from 0.35 to 1.58 mg/g seed. These biochemical traits showed considerable genetic variability, indicating that only the collection of seeds from many different trees can provide a representative sample of the population for conservation and genetic improvement.