Fertilização e desenvolvimento embrionário: Morfometria e análise estereomicroscópica dos ovos dos híbridos de surubins (pintado, Pseudoplatystoma corruscans x cachara, Pseudoplatystoma fasciatum)

This study aimed to analyze the morphometry of hybrids' eggs under stereomicroscopy. The induced reproduction was carried out in specimens of pintado's females (P. corruscans) and cachara's males (P. fasciatum) from Cepta - Ibama, Pirassununga, state of São Paulo, Brazil. Samples were collected in extrusion moment, during the fertilization, in times of 10 and 30 seconds, 1, 2, 5, 8, 10, 15, 20, 30 and 45 minutes, 1 hour, at every 15 minutes until completing 2 hours, and afterwards, at every hour until the larval hatching. Oocytes and eggs' external morphology were observed, photographed and 30 samples from each moment were measured in stereomicroscopy. Oocytes, in the time of extrusion, and the eggs presented a spherical form and yellowish color. Characteristics such as wide perivitelinic space, somites, presence of optical vesicle and the main phases of embryonic development as egg-cell (blastodisc), 2, 4, 8, 16, 32 and 64 blastomeres, morula, blastula, gastrula, epiboly movements, formation and larvae hatching were verified.

Planejamento, síntese e avaliação farmacológica de compostos híbridos potencialmente ativos para o tratamento da anemia falciforme

Sickle cell disease (SCD) is a hereditary hemolytic anemia caused by the inheritance of one S hemoglobin gene from each ancestor. Patients with SCD present increased circulating levels of cytokines, including TNF-alpha (TNF-α). Hydroxyurea (HU) is the available therapeutically strategy for treatment; it acts as a source of nitric oxide and benefits patients by increasing the levels of fetal hemoglobin (HbF). Thus, within one research line that aims at finding new drugs, a series of compounds with TNF-α inhibition and nitric oxide donation properties have been synthesized in order to explore possible synergism of actions beneficial in the treatment of the disease. Six compounds were synthesized: five derivatives of organic nitrates and one of sulfonamide. The compounds, (1,3-dioxo-1,3-dihydro-2Hisoindol-2-yl) methyl nitrate (compound I); (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) ethyl nitrate (compound II); 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) benzyl nitrate (compound III);4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-hydroxybenzenesulfonamide (compound IV); 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) benzyl nitrate (compound V) and 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) phenyl]ethyl nitrate (compound VI), were synthesized using linear synthetic methodology, with excellent overall yields. All compounds showed anti-inflammatory and analgesic effects with a reduction in 43%-65% of ear edema in mice and a reduction of 25%-42% of writhing induced by acetic acid. All compounds showed comparable reductions in the leukocyte infiltration capacity and ability to generate nitric oxide. The aryl compounds (III, IV and V) presented less mutagenic activity compared to compounds I, II and VI according to the salmonella mutagenicity assay (Ames test). Compounds IV and VI showed activity in K562 culture cells, with increases in gamma globin gene expression to levels higher than with hydroxyurea suggesting a potential to increase fetal hemoglobin. This data set characterizes new potentially useful drug candidates for the treatment of symptoms of sickle cell anemia.

Paleosuperfícies e perfis bauxíticos no Planalto de Poços de Caldas, São Paulo/Minas Gerais, Brasil

This work has the objective of correlating altitude with the bauxite profiles in the Poços de Caldas Plateau in order to identify paleosurfaces. Then, bauxite profiles found in the Plateau have been classified and mapped through DEM. Three different types of bauxite profiles are highlighted in the area: (1) Rim Profiles which are well-developed and thick and are located in the areas of highest altitude in the Plateau; (2) Plateau Profiles which are not very thick and very clayey, normally appear in the lower portion of the landscape; (3) Reworked Profiles, characterized by bauxite reworked fragments composed by similar materials found in the tops of Rim and Plateau Profiles. After relating altitude to the constituting materials of the bauxite profiles, it is noticed that there are occurrences of Rim Bauxite Profiles located in altitudes of Plateau Profiles and Reworked Profiles located over Rim Profiles, above 1,400 meters of altitude. In the opposite direction, tops of the same elevation are found, where there should be Rim Profiles, there are rocky outcrops observed in field, without any evidence of laterite profiles. It is concluded, therefore, that the elevation rates by themselves, at least in this area, are not good enough references to determine the existence and distribution of paleosurfaces.

Características morfogênicas e estruturais de híbridos de sorgo submetidos a adubação nitrogenada

The effect of two topdressing nitrogen doses was evaluated on the morphogenetic and structural characteristics of sorghum hybrids (Sorghum bicolor (L.) Moench) BRS 801 and 0734006, cultivated in vases in open-air conditions. A completely randomized design was used with four treatments arranged in factorial outline 2x2 (two sorghum hybrids and two nitrogen doses, 50 and 100 kg ha-1), with eight replications per treatment. There was a significant effect of interaction hybrid x fertilization on the leaf appearance rate, the hybrid BRS 801 being more responsive to the increased nitrogen dose. The phyllochron, the total number of leaves and leaf elongation rate, were influenced both by nitrogen doses and by hybrids. The leaf senescence rate was not influenced by factors fertilization and hybrids. These variations in morphogenetic and structural characteristics between the hybrids and/or nitrogen doses, probably indicate that hybrids respond in a different way to topdressing.

Avaliação de híbridos de mamona de porte baixo em espaçamento reduzido em condições de safrinha

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Análise comparativa da produtividade de híbridos de mamoneira (Ricinus communis L.) obtidos por meio da hibridação convencional e do método de híbridos crípticos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Manejo da adubação nitrogenada em híbridos de mamona de porte baixo cultivados na safra e na safrinha em sistema plantio direto

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Recuperação de perfis atmosféricos a partir de ocultação GPS: fundamentos, implementação e análise de resultados

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Métodos híbridos de pontos interiores e de programação inteira 0-1 para problemas de custo de colheita da cana-de-açúcar e de custo de coleta e geração de energia relacionados à sua biomassa

Pós-graduação em Engenharia Elétrica - FEB

Contribuição ao estudo bioquímico de polpa de híbridos da cultivar maracujá amarelo azedo (Passiflora edulis f. flavicarpa Degener): enzimas e compostos bioativos

Pós-graduação em Biotecnologia - IQ

Produtividade e perdas na colheita de dois cultivares híbridos de milho em função da velocidade de semeadura

Pós-graduação em Agronomia (Ciência do Solo) - FCAV

Caracterização físico-química e rendimento da moagem úmida de quatro híbridos de milho

Pós-graduação em Engenharia e Ciência de Alimentos - IBILCE

Formadores de filmes híbridos orgânicos inorgânicos do tipo ureasil-poliéter para liberação controlada de fármacos

Pós-graduação em Ciências Farmacêuticas - FCFAR

Efeito do manejo de solo nos parâmetros agronômicos e energéticos de híbridos de milho transgênico e não transgênico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Infestação e danos de Dichelops melacanthus (Dallas, 1851) (Heteroptera: Pentatomidae) em híbridos transgênicos e convencionais de milho, submetidos ao controle químico

Pós-graduação em Agronomia (Entomologia Agrícola) - FCAV