816 resultados para PHOTOGRAPHY


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És un estudi sobre el funcionament de la terminologia, en les llengües catalanes i anglesa, sobre un camp semàntic concret que no ofereix gaires equivalents cap a la llengua anglesa: la gastronomia, més en concret, les postres catalanes. Havent-hi aquest buit terminològic, també hi consta una sèrie de propostes neològiques

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PURPOSE: Retinitis pigmentosa (RP; MIM 268000) is a hereditary disease characterized by poor night vision and progressive loss of photoreceptors, eventually leading to blindness. This degenerative process primarily affects peripheral vision due to the loss of rods. Autosomal recessive RP (arRP) is clinically and genetically heterogeneous. It has been associated with mutations in different genes, including CRB1 (crumbs homolog 1). The aim of this study was to determine the causative gene in a Tunisian patient with arRP born to non-consanguineous parents. METHODS: Four accessible family members were included. They underwent full ophthalmic examination with best-corrected Snellen visual acuity, fundus photography and fluorescein angiography. Haplotype analysis was used to evaluate homozygosity in the family to 20 arRP loci. All exons and intron-exon junctions of candidate genes not excluded by haplotype analysis were PCR amplified and directly sequenced. RESULTS: The proband was a 43-year-old female patient. Best-corrected visual acuity was 20/63 (right eye) and 20/80 (left eye). Visual loss began during the third decade. Funduscopic examination and fluorescein angiography revealed typical advanced RP changes with bone spicule-like pigment deposits in the posterior pole and the midperiphery along with retinal atrophy, narrowing of the vessels, and waxy optic discs. Haplotype analysis revealed homozygosity with microsatellite markers D1S412 and D1S413 on chromosome 1q31.3. These markers flanked CRB1. Our results excluded linkage of all the other arRP loci/genes tested. Sequencing of the 12 coding exons and splice sites of CRB1 disclosed a homozygous missense mutation in exon 7 at nucleotide c. 2291G>A, resulting in an arginine to histidine substitution (p.R764H). CONCLUSIONS: R764H is a novel mutation associated with CRB1-related arRP. Previously, an R764C mutation was reported. Extending the mutation spectrum of CRB1 with additional families is important for genotype-phenotype correlations and characterization of the scope of mutation.

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There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and replicated findings in four independent Caucasian cohorts (n  =  6,652). All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single nucleotide polymorphisms (SNP) spread across five loci were significantly associated (p<5.0×10(-8)) with retinal venular caliber, but none showed association with arteriolar caliber. Collectively, these five loci explain 1.0%-3.2% of the variation in retinal venular caliber. Four out of these five loci were confirmed in independent replication samples. In the combined analyses, the top SNPs at each locus were: rs2287921 (19q13; p  =  1.61×10(-25), within the RASIP1 locus), rs225717 (6q24; p = 1.25×10(-16), adjacent to the VTA1 and NMBR loci), rs10774625 (12q24; p  =  2.15×10(-13), in the region of ATXN2,SH2B3 and PTPN11 loci), and rs17421627 (5q14; p = 7.32×10(-16), adjacent to the MEF2C locus). In two independent samples, locus 12q24 was also associated with coronary heart disease and hypertension. Our population-based genome-wide association study demonstrates four novel loci associated with retinal venular caliber, an endophenotype of the microcirculation associated with clinical cardiovascular disease. These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular disease.

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Landscape research in urban or peri-urban areas implies important methodological constraints. In this sense, the area of study, placed in the Vallès basin, near the city of Barcelona, has known an important process of urbanization in the last two decades. This fact restrains the retrieving of archaeological data and the development of archaeological surveys and field-walking. The particular topography of the area must also be taken into account. It is characterised by soft slopes resulting from a differentiated seasonal rainfall. Archaeomorphological analysis has been therefore reconsidered in order to adapt its methods and techniques to this particular environment. The destruction of large agrarian areas implies that landscape morphology research must focus on an intensive work through historical cartography and old aerial photography within a gis environment. The article presents the results of the archaeological research developed in this area. The methodological approach previously exposed and the diversity of sources analysed has allowed us to characterize the ancient road network and to identify field systems from different periods.

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According to Ray Harryhausen, a special effects expert in the film industry, "Gustave Doré would have made a great director of photography . . . He saw things from the point of view of the camera." Doré's work has had a permanent impact on the imaginative realm of film since its very early days. In return, the silver screen has etched Doré into the 20th century imagination. Almost every film about the Bible since The Life and Passion of Jesus Christ produced by Pathé in 1902 refers to his illustrations, and every film adaptation of Dante or Don Quixote has used him as a model, from Georg Wilhelm Pabst and Orson Welles to Terry Gilliam. All films dealing with life in London in the Victorian era by directors ranging from David Lean, to Roman Polanski and Tim Burton draw on the visions in London: a pilgrimage for their sets. A large number of dream fantastical or phantasmagorical scenes take their inspiration from Doré's graphic world, beginning with Georges Méliès' A Trip to the Moon in 1902. In the realm of cartoons and animation, Walt Disney owes a huge debt to Doré. Doré primal forests, from Atala in particular, were also used in the various versions of King Kong from 1933 to the 2005 film by Peter Jackson, who had already drawn on Doré for The Lord of the Rings. Jean Cocteau was also indebted to the illustrations for Perrault's Fairy Tales for his Beauty and the Beast (1945), as was George Lucas for the character Chewbacca in Star Wars (1977) and even the Harry Potter film series. Through his influence on film history, Doré shaped the mass culture imagination.

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PURPOSE: To investigate six cases of annular cyclitis. METHODS: All patients with impairment of visual acuity underwent complete ophthalmologic examination, color fundus photography, laboratory tests and fluorescein angiography. Indocyanine green (ICG) angiography and B-scan ultrasonography were also performed in three cases in order to diagnose the disease. RESULTS: All patients presented a unilateral or bilateral granulomatous uveitis, associated with inflammatory annular cyclitis. They had a shallow anterior chamber, a mildly elevated intraocular pressure (under 25 mm Hg) and an annular serous retinal detachment. A resolution was observed after specific therapy associated with systemic prednisolone therapy and antiglaucomatous drops. CONCLUSION: This is the first description of an observational study of six patients with inflammatory annular cyclitis.

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Landscape research in urban or peri-urban areas implies important methodological constraints. In this sense, the area of study, placed in the Vallès basin, near the city of Barcelona, has known an important process of landscape’s transformation in the last two decades. This fact restrains the retrieving of archaeological data and the development of archaeological surveys and fieldwalking. The destruction of large agrarian areas implies that landscape morphology research must focus on an intensive work with historical cartography and old aerial photography within a GIS environment.

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Durant la última dècada hem viscut l’explosió de la fotografia digital. Les possibilitats de captar imatges s’ha multiplicat de manera gairebé infinita sense implicar costos afegits pel fotògraf. Això ens obliga a replantejar-nos la necessitat d’establir uns criteris ben definits per avaluar, triar i eliminar les fotografies que ingressen als nostres arxius. El treball que es presenta aquí té com a objectiu establir uns protocols per tal de poder aplicar aquests procediments al nous fons que passin a formar part del nostre patrimoni documental. Finalment, s’ha dut a terme l’experiència d’entregar al productor d’un fons part de la seva documentació per tal que ell l’avalués i després comparar els resultats amb l’avaluació duta a terme des de l’arxiu. Paraules clau: avaluació, tria, eliminació, fotografia born-digital, ingrés, metadades, arxiu digital, formats de preservació

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PURPOSE: To evaluate the clinical characteristics of the 3 classifications of vitreous seeds in retinoblastoma-dust (class 1), spheres (class 2), and clouds (class 3)-and their responses to intravitreal melphalan. DESIGN: Retrospective, bi-institutional cohort study. PARTICIPANTS: A total of 87 patient eyes received 475 intravitreal injections of melphalan (median dose, 30 μg) given weekly, a median of 5 times (range, 1-12 times). METHODS: At presentation, the vitreous seeds were classified into 3 groups: dust, spheres, and clouds. Indirect ophthalmoscopy, fundus photography, ultrasonography, and ultrasonic biomicroscopy were used to evaluate clinical response to weekly intravitreal melphalan injections and time to regression of vitreous seeds. Kaplan-Meier estimates of time to regression and ocular survival, patient survival, and event-free survival (EFS) were calculated and then compared using the Mantel-Cox test of curve. MAIN OUTCOME MEASURES: Time to regression of vitreous seeds, patient survival, ocular survival, and EFS. RESULTS: The difference in time to regression was significantly different for the 3 seed classes (P < 0.0001): the median time to regression was 0.6, 1.7, and 7.7 months for dust, spheres, and clouds, respectively. Eyes with dust received significantly fewer injections and a lower median and cumulative dose of melphalan, whereas eyes with clouds received significantly more injections and a higher median and cumulative dose of melphalan. Overall, the 2-year Kaplan-Meier estimates for ocular survival, patient survival, and EFS (related to target seeds) were 90.4% (95% confidence interval [CI], 79.7-95.6), 100%, and 98.5% (95% CI, 90-99.7), respectively. CONCLUSIONS: The regression and response of vitreous seeds to intravitreal melphalan are different for each seed classification. The vitreous seed classification can be predictive of time to regression, number, median dose, and cumulative dose of intravitreal melphalan injections required.

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Background: Malignant hypertension is defined by marked systemic arterial hypertension with retinal haemorrhages, exudation or papilloedema. Due to the rarity of this disease and due to its non-specific symptoms and lesions, the diagnosis can be challenging. Patients and Methods We investigated the types of symptoms and ocular lesions observed with ocular fundus examination, ocular fundus photography, fluorescein angiography and optical coherence tomography in a small case series of 7 patients with malignant hypertension. Results: Median systolic blood pressure (BP) was 205 mmHg ± 21. Median diastolic BP was 150 mmHg ± 16. Decrease in visual acuity (6/7 patients) and scotoma (5/7) were the main symptoms and Elschnig spot, flamed shaped haemorrhage, serous retinal detachment, cotton wool spots and optic nerve oedema were the five most frequently observed lesions. A regression of lesions was observed after therapy of systemic hypertension. Conclusion: The association of multiple lesions strongly suggests malignant hypertension. However even in cases with only one lesion malignant hypertension should be kept in mind.

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Miltä sinusta tuntuisi nähdä vanhenevasi viisikymmentä vuotta minuutissa? Time-lapse -kuvaus on nykytekniikalla ainoa keino ihmisille matkustaa ajassa. Tällä kuvaustavalla on mahdollista hidastaa elämää tai vastaavasti nopeuttaa sitä. Tämän opinnäytetyön tarkoituksena on käydä läpi ne keinot ja tekniikat kuinka time-lapse -kuvia voidaan tehdä. Työn tavoitteena on ollut ymmärtää time-lapse -kuvaamista ja tutustua eri efekteihin, joita voi tehdä intervallikuvauksen avulla. Työhön on tehty kuvamateriaalia kirjallisen osan tueksi, jotta lukijan olisi mahdollisimman helppo ymmärtää kuvaustapaa. Työhön on tehty kaavoja ja kuvia, jotka antavat lukijalle mahdollisuuden myös kokeilla kuvien ottamista. Työssä on kerrottu kuvien ottamisesta ja siinä helposti tehtävistä virheistä, jotta lukijan ei tarvitsisi omissa kokeiluissaan ajaa samoihin ansoihin, kuin opinnäytetyötä tehdessä on ajettu. Time-lapse -kuvaaminen on kiehtova tapa tuoda kaikki valokuvauksen keinot elokuvaan. Tämä työ on tehty sitä varten, että tekijä itse on syventänyt ymmärrystään kuvaustapaan ja siksi, että lukija voisi suunnitella kuvauksiaan monipuolisemmin. Tämä työ käy time-lapse -kuvaamisen pinnalla. Syvemmällä kuvaustavan sisällä on miljoonia keinoja, joita on mahdollista löytää, kokeilla ja käyttää. Tämän työn tarkoituksena on olla alku matkalle, joka vie mukanaan kokeilemaan uusia keinoja, joita ei ehkä kuvien digitaalisuuden tuomien mahdollisuuksien myötä ole vielä edes löydetty.

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El objetivo del proceso de investigación de mi Trabajo de Fin de Grado recae en los beneficios que tienen la naturaleza y los animales sobre las personas con diversidad funcional y más precisamente sobre las personas con trastorno mental. Lo que me motivó en esta investigación fue en primer lugar mi pasión por estos ámbitos y en segundo lugar porque conocía la existencia de dos proyectos magníficos. Uno en el Zoo de Barcelona (Proyecto de voluntariado de personas con Trastorno Mental grave con el Zoo de Barcelona) y otro en la protectora de perros y gatos (CCAAS : Centro Comarcal de Atención a animales de compañía). Para eso me he sumergido en estos proyectos para poder comprender el impacto que tenía la naturaleza y los animales sobre los usuarios. Han participado directamente cinco usuarios. He usado varias metodologías como la observación, el diario de campo, la fotografía y la entrevista semi-estructurada. Los resultados extraídos de la investigación muestran como existen beneficios y tienen un impacto positivo hacia las dimensiones bio-psico-social de las personas con trastorno mental. Las limitaciones del proyecto dependen de la voluntad de participación de cada usuario y a la naturaleza del estudio.