View from Deck; Albert Einstein's Weekend Home; Caputh, near Berlin Architecture; Residences; Exterior

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Elsa Einstein with unidentified woman sitting on the porch of Albert Einstein's Weekend Home; Caputh, near Berlin Architecture; Residences; Exterior

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Portrait of the engaged couple Albert Meyerhof and Dina Loebenberg. Portraits Couples

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Portrait of Albert Meyerhof called "Nuck"; Israel.

Photo taken in Israel.

Ilse and Robert Goldschmidt with their parents Albert Goldschmidt and Elly nee Schoenbeck grandfather Albert Schoenbeck and great grandmother Sophie Schoenbeck nee Mahler. Portraits Family

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Obituary of Albert Goldschmidt; Cologne, Germany.

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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10−9 to P = 1.8 × 10−40) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10−3 to P = 1.2 × 10−13). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

Albert Einstein; Princeton, New Jersey Portraits; Men

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Albert Einstein; Princeton, New Jersey Portraits; Men

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Albert Einstein; Princeton, New Jersey Portraits; Men

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Albert Einstein Portraits; Men

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Albert Einstein "The Giant"; New Jersey Portraits; Men

"Der Riese"