CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice

Trimolecular interactions between the T cell antigen receptor and MHC/peptide complexes, together with costimulatory molecules and cytokines, control the initial activation of naïve T cells and determine whether the helper precursor cell differentiates into either T helper (TH)1 or TH2 effector cells. We now present evidence that regulatory CD8+ T cells provide another level of control of TH phenotype during further evolution of immune responses. These regulatory CD8+ T cells are induced by antigen-triggered CD4+ TH1 cells during T cell vaccination and, in vitro, distinguish mature TH1 from TH2 cells in a T cell antigen receptor Vβ-specific and Qa-1-restricted manner. In vivo, protection from experimental autoimmune encephalomyelitis (EAE) induced by T cell vaccination depends on CD8+ T cells, and myelin basic protein-reactive TH1 Vβ8+ clones, but not TH2 Vβ8+ clones, used as vaccine T cells, protect animals from subsequent induction of EAE. Moreover, in vivo depletion of CD8+ T cells during the first episode of EAE results in skewing of the TH phenotype toward TH1 upon secondary myelin basic protein stimulation. These data provide evidence that CD8+ T cells control autoimmune responses, in part, by regulating the TH phenotype of self-reactive CD4+ T cells.

Thermal Runaway in Tubular Reactor Systems with n-th Order Kinetics

This paper addresses the problem of predicting the critical parameters that characterize thermal runaway in a tubular reactor with wall cooling, introducing a new view of the n-th order kinetics reactions. The paper describes the trajectories of the system in the temperature-(concentration)n plane, and deduces the conditions for the thermal risk.

Katalog der Paläarktischen dipteren / bearbeitet von Th. Becker ... [et al.].

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Katalog der Paläarktischen dipteren / bearbeitet von Th. Becker ... [et al.].

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Katalog der Paläarktischen dipteren / bearbeitet von Th. Becker ... [et al.].

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Katalog der Paläarktischen dipteren / bearbeitet von Th. Becker ... [et al.].

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An Acct of Several things relating to ye Coll: contained in ye Charter Laws &c: w'th references to the Originals (manuscript copy), 1721 October 17

Two folio-sized leaves containing a three-page handwritten report sent by Nicholas Sever and William Welsteed to Judge Samuel Sewall outlining the historical precedence for the Tutors' claims. The body of the text begins, "What we assert in ye first place..."

Talfīq al-akhbār wa-talqīḥ al-āth��r fī waqāʻiʻ Qāzān wa-Bulghār wa-mulūk al-Tatār

athar M. M. al-Ramzī.