Open Access Research Data Repository for Corpus Linguistic Data – A Modular Approach

Presentation at Open Repositories 2014, Helsinki, Finland, June 9-13, 2014

Jerusalem et suburbia eius, sic ut tempore Christi floruit cum locis in quibus Christus passus est ...

Osa I

Franckofordianae civitas situs & figura, qualemhoc Christi anno 1549 habet

Julkaisussa: Cosmographia universalis lib. VI in quibus, juxta certioris fidei scriptorum traditionem describuntur

Axonal pathfinding mechanisms at the cortical midline and in the development of the corpus callosum

The corpus callosum is a large fiber tract that connects neurons in the right and left cerebral hemispheres. Agenesis of the corpus callosum (ACC) is associated with a large number of human syndromes but little is known about why ACC occurs. In most cases of ACC, callosal axons are able to grow toward the midline but are unable to cross it, continuing to grow into large swirls of axons known as Probst bundles. This phenotype suggests that in some cases ACC may be due to defects in axonal guidance at the midline. General guidance mechanisms that influence the development of axons include chemoattraction and chemorepulsion, presented by either membrane-bound or diffusible molecules. These molecules are not only expressed by the final target but by intermediate targets along the pathway, and by pioneering axons that act as guides for later arriving axons. Midline glial populations are important intermediate targets for commissural axons in the spinal cord and brain, including the corpus callosum. The role of midline glial populations and pioneering axons in the formation of the corpus callosum are discussed. Finally the differential guidance of the ipsilaterally projecting perforating pathway and the contralaterally projecting corpus callosum is addressed. Development of the corpus callosum involves the coordination of a number of different guidance mechanisms and the probable involvement of a large number of molecules.

One hundred million years of interhemispheric communication: the history of the corpus callosum

Analysis of regional corpus callosum fiber composition reveals that callosal regions connecting primary and secondary sensory areas tend to have higher proportions of coarse-diameter, highly myelinated fibers than callosal regions connecting so-called higher-order areas. This suggests that in primary/secondary sensory areas there are strong timing constraints for interhemispheric communication, which may be related to the process of midline fusion of the two sensory hemifields across the hemispheres. We postulate that the evolutionary origin of the corpus callosum in placental mammals is related to the mechanism of midline fusion in the sensory cortices, which only in mammals receive a topographically organized representation of the sensory surfaces. The early corpus callosum may have also served as a substrate for growth of fibers connecting higher-order areas, which possibly participated in the propagation of neuronal ensembles of synchronized activity between the hemispheres. However, as brains became much larger, the increasingly longer interhemispheric distance may have worked as a constraint for efficient callosal transmission. Callosal fiber composition tends to be quite uniform across species with different brain sizes, suggesting that the delay in callosal transmission is longer in bigger brains. There is only a small subset of large-diameter callosal fibers whose size increases with increasing interhemispheric distance. These limitations in interhemispheric connectivity may have favored the development of brain lateralization in some species like humans. "...if the currently received statements are correct, the appearance of the corpus callosum in the placental mammals is the greatest and most sudden modification exhibited by the brain in the whole series of vertebrated animals..." T.H. Huxley (1).

De anima Christi

Variantti A.

De officio Christi sacerdotali

Arkit: A-B4 C2. - S. [2] tyhjä.

De conjugio, praesertim ministrorum verbi, & spiritualibus Christi & ecclesiae nuptijs, quarum illi sunt conciliatores

Arkit: A-C4.

De controversia: an resurrectio Christi pertineat ad opus redemptionis nostrae? nec ne?

Invokaatio: I.N.D.I.R.

De cognitione Dei et Christi usum rationis supponente, locos Joh. XVII:3. & I Cor. II:14. illustratura

Invokaatio: D.D.

De forma, altero, interno, nobiliori, essentiali principio corpus naturale constituente

Variantti C.

De statu exinanitionis Christi Jesu

Variantti A.

De expiatione Jesu Christi vicaria 2:1

Invokaatio: D.D.

De imputatione justitiae Christi 3

Invokaatio: I.N.J.