Progettazione di un sistema di sollevamento per la dismissione di un serbatoio per olio combustibile denso

Petroltecnica S.P.A, azienda leader in attività di bonifica di terreni e siti industriali, ha svolto, per conto di Enipower Ferrara, uno studio di fattibilità per la dismissione di un serbatoio di olio combustibile e linea di tubazioni annesse. La richiesta della committente prevedeva la movimentazione del serbatoio di olio combustibile senza operare sezionamenti, in modo da poterlo bonificare al di fuori del sito in apposita area attrezzata. Per questo motivo è stato progettato un sistema di sollevamento che permettesse di movimentare il serbatoio di olio combustibile senza rischiare di deformarlo o romperlo. La struttura del bilancino è caratterizzata da una trave principale su cui è stata saldata una staffa per il collegamento del gancio della gru con la trave principale, e a cui sono collegate due travi traverse, disposte perpendicolarmente, e due staffe laterali. Alle estremità di ciascuna trave (principale e secondarie) sono presenti delle staffe a cui è collegata la componentistica di attacco del carico (grilli, funi e golfari). La progettazione del sistema di sollevamento è stata fatta in modo da ripartire uniformemente il carico sulla struttura e contemporaneamente non sollecitare eccessivamente i punti di presa del serbatoio. Una volta scelta la struttura del bilancino, è stato necessario dimensionare e verificare tutte le sue parti sulla base del metodo delle tensioni ammissibili previsto dall'UNI 10011. In riferimento alle normative UNI 10011 e UNI 13155, il dimensionamento del bilancino di sollevamento è stato effettuato in modo da ottenere, su ciascun elemento della struttura, un coefficiente di sicurezza minimo pari a due.

The status of olfactory function and the striatal dopaminergic system in drug-induced parkinsonism

Olfactory impairment has been reported in drug-induced parkinsonism (DIP), but the relationship between dopaminergic dysfunction and smell deficits in DIP patients has not been characterized. To this end, we studied 16 DIP patients and 13 patients affected by Parkinson's disease (PD) using the "Sniffin' Sticks" test and [(123)I] FP-CIT SPECT (single-photon emission computed tomography). DIP patients were divided based on normal (n = 9) and abnormal (n = 7) putamen dopamine transporter binding. Nineteen healthy age- and sex-matched subjects served as controls of smell function. Patients with DIP and pathological putamen uptake had abnormal olfactory function. In this group of patients, olfactory TDI scores (odor threshold, discrimination and identification) correlated significantly with putamen uptake values, as observed in PD patients. By contrast, DIP patients with normal putamen uptake showed odor functions-with the exception of the threshold subtest-similar to control subjects. In this group of patients, no significant correlation was observed between olfactory TDI scores and putamen uptake values. The results of our study suggest that the presence of smell deficits in DIP patients might be more associated with dopaminergic loss rather than with a drug-mediated dopamine receptor blockade. These preliminary results might have prognostic and therapeutic implications, as abnormalities in these individuals may be suggestive of an underlying PD-like neurodegenerative process.

Organ transplantation in Switzerland: impact of the new transplant law on cold ischaemia time and organ transports

On 1 July 2007 a new transplant law came into force in Switzerland. The principal item of this new law is the change from centre-oriented allocation to patient-oriented national allocation of organs. The aim of the present study is to assess the impact on cold ischaemia time (CIT) and transport requirements.

Human Preferences for Symmetry: Subjective Experience, Cognitive Conflict and Cortical Brain Activity

This study examines the links between human perceptions, cognitive biases and neural processing of symmetrical stimuli. While preferences for symmetry have largely been examined in the context of disorders such as obsessive-compulsive disorder and autism spectrum disorders, we examine various these phenomena in non-clinical subjects and suggest that such preferences are distributed throughout the typical population as part of our cognitive and neural architecture. In Experiment 1, 82 young adults reported on the frequency of their obsessive-compulsive spectrum behaviors. Subjects also performed an emotional Stroop or variant of an Implicit Association Task (the OC-CIT) developed to assess cognitive biases for symmetry. Data not only reveal that subjects evidence a cognitive conflict when asked to match images of positive affect with asymmetrical stimuli, and disgust with symmetry, but also that their slowed reaction times when asked to do so were predicted by reports of OC behavior, particularly checking behavior. In Experiment 2, 26 participants were administered an oddball Event-Related Potential task specifically designed to assess sensitivity to symmetry as well as the OC-CIT. These data revealed that reaction times on the OC-CIT were strongly predicted by frontal electrode sites indicating faster processing of an asymmetrical stimulus (unparallel lines) relative to a symmetrical stimulus (parallel lines). The results point to an overall cognitive bias linking disgust with asymmetry and suggest that such cognitive biases are reflected in neural responses to symmetrical/asymmetrical stimuli.

The challenge of triaging chest pain patients: the bernese university hospital experience

Accurate diagnosis of the causes of chest pain and dyspnea remain challenging. In this preliminary observational study with a 5-year follow-up, we attempted to find a simplified approach to selecting patients with chest pain needing immediate care based on the initial evaluation in ED. During a 24-month period were randomly selected 301 patients and a conditional inference tree (CIT) was used as the basis of the prognostic rule. Common diagnoses were musculoskeletal chest pain (27%), ACS (19%) and panic attack (12%). Using variables of ACS symptoms we estimated the likelihood of ACS based on a CIT to be high at 91% (32), low at 4% (198) and intermediate at 20.5-40% in (71) patients. Coronary catheterization was performed within 24 hours in 91% of the patients with ACS. A culprit lesion was found in 79%. Follow-up (median 4.2 years) information was available for 70% of the patients. Of the 164 patients without ACS who were followed up, 5 were treated with revascularization for stable angina pectoris, 2 were treated with revascularization for myocardial infarction, and 25 died. Although a simple triage decision tree could theoretically help to efficient select patients needing immediate care we need also to be vigilant for those presenting with atypical symptoms.

An interfering Go/No-go task does not affect accuracy in a Concealed Information Test

Following the idea that response inhibition processes play a central role in concealing information, the present study investigated the influence of a Go/No-go task as an interfering mental activity, performed parallel to the Concealed Information Test (CIT), on the detectability of concealed information. 40 undergraduate students participated in a mock-crime experiment and simultaneously performed a CIT and a Go/No-go task. Electrodermal activity (EDA), respiration line length (RLL), heart rate (HR) and finger pulse waveform length (FPWL) were registered. Reaction times were recorded as behavioral measures in the Go/No-go task as well as in the CIT. As a within-subject control condition, the CIT was also applied without an additional task. The parallel task did not influence the mean differences of the physiological measures of the mock-crime-related probe and the irrelevant items. This finding might possibly be due to the fact that the applied parallel task induced a tonic rather than a phasic mental activity, which did not influence differential responding to CIT items. No physiological evidence for an interaction between the parallel task and sub-processes of deception (e.g. inhibition) was found. Subjects' performance in the Go/No-go parallel task did not contribute to the detection of concealed information. Generalizability needs further investigations of different variations of the parallel task.

Walter Lorenz – Wegbegleiter und Orientierungspunkt in der interkulturellen Sozialen Arbeit

First meeting, common interests and ways together The European Centre for Social Welfare, Training and Research situated in Vienna, was our first meeting place. W. Lorenz was interested in the international comparison of the different concepts and perspectives of social welfare problems in the European countries and the different developments in the training of social professions in Europe. The challenge of intercultural, antiracist social work in the context of Erasmus-Intensive Seminars To organize an intensive seminar with the aim to train students and colleagues for intercultural and antiracist competence in social professions, we formed an European network of European universities and schools of s.w. in Vienna (VIENNET), with the support of ECCE (European Centre of Community Education) in Koblenz. “The group discovered that working on these issues in an international context raises issues of ‘difference’ with renewed acuteness”(cit. W. Lorenz). We learned to cope with a variety of differences: biographical, language, theoretical and institutional backgrounds and discourse traditions. A Venue for an Intensive Seminar In choosing a venue for an Intensive Seminar we were relatively free. We locked for a place, “one dream about”, to support in the best way our seminar aims, to promote a base built on knowledge, skills and values particularly in the area of inner/outer borders, disadvantage, ignorance, minorities, majorities, vulnerable groups, racism and xenophobia. In a small village in Burgenland (Austria), very close to the Hungarian border, we thought to have found it. Future Prospect Are we only representatives of our background institutions or did we act and exposed ourselves as persons with a very specific biography and training experience. Can we sustain this created network, as a network of experts and friends in the field of intercultural, antiracist social work? This question is still open.

Le Coq et les revues dada

En 1920, Cocteau et Radiguet éditent une revue intitulée Le Coq, qui se présente comme un dépassement de Dada, et qui aboutit à la création d’une « ligue antimoderne ». Pourtant, Dada est plusieurs fois cité dans la revue, qui reprend aussi les caractéristiques typographiques de revues dada. Mais il apparaît que Le Coq n’a pas saisi la «propagande» dada, qui n’utilise les moyens de la publicité que pour s’en abstraire.

Rousseau et le théâtre : le pour et le contre

Mme Michèle Crogiez traite dans sa communication de la querelle du théâtre à Genève entre Jean-Jacques Rousseau et D’Alembert à l’occasion de la publication de l’article "Genève" de l’ "Encyclopédie". La "Lettre à D’Alembert sur les spectacles" (1758) rédigée à Montmorency par Rousseau n’a rien d’une relation de voyage. Rousseau a quitté adolescent sa ville natale, et D’Alembert ne l’a connaît que très imparfaitement par de courts séjours … et par Voltaire. C’est donc d’un lieu largement imaginaire que parlent les deux écrivains. Paradoxalement, Rousseau qui est connu alors par des "discours" scandaleux l’est aussi par sa participation à la querelle des musiques italienne et française et par son activité d’auteur dramatique ("Le Devin de village"). Le contempteur du théâtre à Genève est lui-même homme de théâtre. Si le but de l’article "Genève" est aussi de faire connaître la République helvétique aux Français, le théâtre fait partie de la dimension politique d’une cité et justifie le développement de l’article sur ce qui n’existe pas à Genève, une vie théâtrale officielle. Dans sa "Lettre" (forme habituelle du débat ouvert au XVIIIe siècle), Rousseau emploie de façon récurrente la notion de "patrie" et de "patriotique" pour désigner la spécificité genevoise. Pour Rousseau, les hommes modernes sont corrompus, mais de manière diversifiée. Si les spectacles peuvent être autorisés à Paris (corruption forte et sans espoir de retour), ils doivent être bannis dans les pays où la corruption n’a pas atteint ce degré et où subsiste quelque chose de la primitive honnêteté. Derrière cette querelle, il y a évidemment Voltaire qui tente, des Délices à Carouge, d’introduire à Genève des spectacles théâtraux privés, complices de l’esprit corrupteur (voir ci-dessous sa lettre au marquis Capacelli). Et D’Alembert est son truchement. Chez Rousseau, Genève est une ville d’utopie pour un voyage dans sa mémoire affective, un lieu intime et menacé.

La duchesse d'Enville à Genève, une aristocrate chez les Républicains

Admiratrice de Tronchin, la duchesse d'Enville se rend plusieurs fois à Genève pour de longs séjours. Elle y fréquente toute la bonne société. Et manifestement, elle y apprend à s'intéresser à la politique, à cause des troubles de la cité, qu'elle observe en personne en 1765-1766 et, par l'intermédiaire de ses amis genevois, au début des années 1780. Cette expérience lui a-t-elle servi au début de la révolution française, à l'époque où son salon sert de lieu de rivalité aux Jacobins ?

Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease.

BACKGROUND Catecholamine-O-methyl-tranferase (COMT) initiates dopamine degradation. Its activity is mainly determined by a single nucleotide polymorphism in the COMT gene (Val158Met, rs4680) separating high (Val/Val, COMT(HH)), intermediate (Val/Met, COMT(HL)) and low metabolizers (Met/Met, COMT(LL)). We investigated dopaminergic denervation in the striatum in PD patients according to COMT rs4680 genotype. METHODS Patients with idiopathic PD were assessed for motor severity (UPDRS-III rating scale in OFF-state), dopaminergic denervation using [123I]-FP-CIT SPECT imaging, and genotyped for the COMT rs4680 enzyme. [123I]-FP-CIT binding potential (BP) for each voxel was defined by the ratio of tracer-binding in the region of interest (striatum, caudate nucleus and putamen) to that in a region of non-specific activity. Genotyping was performed using TaqMan(®) SNP genotyping assay. We used a regression model to evaluate the effect of COMT genotype on the BP in the striatum and its sub-regions. RESULTS Genotype distribution was: 11 (27.5%) COMT(HH), 26 (65%) COMT(HL) and 3 (7.5%) COMT(LL). There were no significant differences in disease severity, treatments, or motor scores between genotypes. When adjusted to clinical severity, gender and age, low and intermediate metabolizers showed significantly higher rates of striatal denervation (COMT(HL+LL) BP = 1.32 ± 0.04) than high metabolizers (COMT(HH), BP = 1.6 ± 0.08; F(1.34) = 9.0, p = 0.005). Striatal sub-regions showed similar results. BP and UPDRS-III motor scores (r = 0.44, p = 0.04) (p < 0.001) were highly correlated. There was a gender effect, but no gender-genotype interaction. CONCLUSIONS Striatal denervation differs according to COMT-Val158Met polymorphism. COMT activity may play a role as a compensatory mechanism in PD motor symptoms.

Changes in miRNA Expression in a Model of Microcephaly

miRNAs function to regulate gene expression through post-transcriptional mechanisms to potentially regulate multiple aspects of physiology and development. Whole transcriptome analysis has been conducted on the citron kinase mutant rat, a mutant that shows decreases in brain growth and development. The resulting differences in RNA between mutant and wild-type controls can be used to identify genetic pathways that may be regulated differentially in normal compared to abnormal neurogenesis. The goal of this thesis was to verify, with quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), changes in miRNA expression in Cit-k mutants and wild types. In addition to confirming miRNA expression changes, bio-informatics software TargetScan 5.1 was used to identify potential mRNA targets of the differentially expressed miRNAs. The miRNAs that were confirmed to change include: rno-miR-466c, mmu-miR-493, mmu-miR-297a, hsa-miR-765, and hsa-miR-1270. The TargetScan analysis revealed 347 potential targets which have known roles in development. A subset of these potential targets include genes involved in the Wnt signaling pathway which is known to be an important regulator of stem cell development.

Carlotta Grisi, Hüftbild

Signatur des Originals: S 36/G03096

La abyección y las fronteras en Copi

Partiendo de una tesis doctoral sobre "la abyección como categoría analítica en la obra de Witold Gombrowicz", escrita por Silvana Mandolessi, se toman en cuenta sus investigaciones en torno a la noción de "abyección" (desde un enfoque en parte psicoanalítico y en parte sociopolítico, teniendo en consideración la potencia de resistencia que podría tener "lo abyecto"), para intentar un acercamiento a la obra de otro "extraterritorial", el escritor franco- argentino Copi, considerando la posible productividad del término en la lectura de su novela La ciudad de las ratas (La cité des rats, 1979), donde se percibe un trabajo intenso de ridiculización de las jerarquías que separan lo "aceptable" de lo "inaceptable" dentro de la organización de las sociedades. El desmantelamiento resultante lleva a una reconfiguración de las fronteras entre el "buen" y el "mal" gusto, entre "lo humano" y "lo animal" entre otras, remitiendo así a otras de las obras de Copi donde se realizan planteos similares. A lo largo de su producción, Copi cuestiona ese tipo de fronteras, pero el papel que el potencial político de "lo abyecto" cumple en ese cuestionamiento tiene en La ciudad de las ratas una de sus manifestaciones quizá más importantes

El territorio usado en Milton Santos y la inteligencia territorial en el GDRI INTI : Iniciativas y perspectivas

El territorio usado en Milton Santos es un macro-concepto de notable riqueza y polisemia, y a la vez base, en las próximas décadas, en la construcción de un status científico con escasos precedentes en la Teoría del Territorio. La inteligencia territorial en el GDRI INTI es un macro-concepto en formación y desarrollo en Europay en América Latina, con una capacidad notable de articulación entre Teorías Sociales, Territoriales y de la Transformación al servicio de un campo científico multidisciplinar con gran futuro. Por génesis y desarrollo, territorio usado e inteligencia territorial se inscriben en el denominado paradigma emergente en las ciencias (de Sousa, 2009). Traducción mediante con los sujetos del objeto ¿En qué medida cosas y relaciones juntas, materializadas en técnicas, resignificadas en acontecimientos y sujetas a relaciones de poder no sólo son explanans y explanandum de cualquier territorio usado, sino que pueden constituir base para la co-construcción de territorios bien usados y/o mejor usados mediante las difíciles interfaces de conocimientos (Long, 2007) y ecologías de saberes (de Sousa, op.cit.)? Este interrogante dispara la hipótesis de este trabajo: su intento por responderlo se trabaja interpretando proyectos de Inteligencia Territorial concretos en América Latina y Europa hace poco más de tres años