Fundamento teórico-conceptual que sustenta y orienta el papel del fisioterapeuta en programas de promoción de la salud y educación en salud dirigidos a la población de los cuidadores del adulto mayor con discapacidad en el col santa fe candelaria de Bogotá, D.C.

El hombre como ser social siente la necesidad de organizarse para satisfacer sus necesidades y las de su contexto, es por eso que utilizamos estrategias de vinculación de individuos y establecemos relaciones que nos permiten el intercambio de experiencias, metodologías y recursos que orientan nuestro quehacer, como en la labor de cuidar; la cual requiere de varias acciones encaminadas hacia el desarrollo optimo de su tarea y demanda del apoyo adecuado que facilite su desempeño. Esta labor se hace aún más dispendiosa cuando se tiene bajo el cuidado un miembro cercano de nuestra familia o una persona a quien le tenemos gran afecto y debemos gran respeto, como sucede con un adulto mayor en situación de discapacidad.

La experiencia del proceso de desarrollo e internacionalización de las zonas francas industriales y comerciales colombianas

Entrar al análisis de los factores de liderazgo de las zonas francas de Colombia, República Dominicana y Taiwán, resulta básico abordar el tema del liderazgo empresarial, como la estructura principal del éxito en las organizaciones del mundo

La incidencia del Movimiento Islámico de Uzbekistán en el establecimiento de una agenda de seguridad uzbeka en Asia Central 1991-2012

El interés del presente estudio de caso es analizar la estrategia de securitización implementada por el Presidente de la Republica de Uzbekistán Islam Karimov sobre el Movimiento Islámico de Uzbekistán. Se describe y se explica cómo desde las lógicas históricas y étnicas acontecidas en Asia Central, se pueden comprender los alcances internacionales de la confrontación antagónica ejercida entre uzbekos al apoyar ideas de corte secular e islamista. Así, siguiendo los parámetros establecidos por Barry Buzan con respecto a la securitización, se puede llegar a identificar la creación de una agenda de seguridad uzbeka en la región de Asia Central, cuyos logros permitieron disminuir el riesgo de la amenaza insurgente.

La Organización de Cooperación de Shanghái (OCS): ¿una alianza estratégica Sino-Rusa para el control de Asia Central? (2001-2014)

La presente monografía pretende analizar en qué medida el co-liderazgo sino-ruso de la Organización de Cooperación de Shanghái puede condicionar la hegemonía estadounidense en Asia Central. Esta investigación defiende que los objetivos del co-liderazgo sino-ruso de la OCS - garantizar un orden multipolar del Sistema Internacional; obtener el acceso, control y explotación de los recursos (naturales, minerales e hídricos); disminuir la influencia política y militar de Estados Unidos en dicho pivote geopolítico - evidencian una contraposición al código geopolítico estadounidense en Asia Central, lo cual genera un limitante a su proyecto de hegemonía en la región. Para sustentar lo anterior se utilizan categorías analíticas propias de la Geopolítica de autores como Zbigniew Brzezinski, Saul Cohen y Peter Taylor, las cuales se contrastan con las estrategias de Rusia, China y Estados Unidos en Asia Central.

The major central endocannabinoid directly acts at GABA(A) receptors

GABA(A) receptors are the major ionotropic inhibitory neurotransmitter receptors. The endocannabinoid system is a lipid signaling network that modulates different brain functions. Here we show a direct molecular interaction between the two systems. The endocannabinoid 2-arachidonoyl glycerol (2-AG) potentiates GABA(A) receptors at low concentrations of GABA. Two residues of the receptor located in the transmembrane segment M4 of β(2) confer 2-AG binding. 2-AG acts in a superadditive fashion with the neurosteroid 3α, 21-dihydroxy-5α-pregnan-20-one (THDOC) and modulates δ-subunit-containing receptors, known to be located extrasynaptically and to respond to neurosteroids. 2-AG inhibits motility in CB(1)/CB(2) cannabinoid receptor double-KO, whereas β(2)-KO mice show hypermotility. The identification of a functional binding site for 2-AG in the GABA(A) receptor may have far-reaching consequences for the study of locomotion and sedation.

UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation

Global transcriptomic and proteomic profiling platforms have yielded important insights into the complex response to ionizing radiation (IR). Nonetheless, little is known about the ways in which small cellular metabolite concentrations change in response to IR. Here, a metabolomics approach using ultraperformance liquid chromatography coupled with electrospray time-of-flight mass spectrometry was used to profile, over time, the hydrophilic metabolome of TK6 cells exposed to IR doses ranging from 0.5 to 8.0 Gy. Multivariate data analysis of the positive ions revealed dose- and time-dependent clustering of the irradiated cells and identified certain constituents of the water-soluble metabolome as being significantly depleted as early as 1 h after IR. Tandem mass spectrometry was used to confirm metabolite identity. Many of the depleted metabolites are associated with oxidative stress and DNA repair pathways. Included are reduced glutathione, adenosine monophosphate, nicotinamide adenine dinucleotide, and spermine. Similar measurements were performed with a transformed fibroblast cell line, BJ, and it was found that a subset of the identified TK6 metabolites were effective in IR dose discrimination. The GEDI (Gene Expression Dynamics Inspector) algorithm, which is based on self-organizing maps, was used to visualize dynamic global changes in the TK6 metabolome that resulted from IR. It revealed dose-dependent clustering of ions sharing the same trends in concentration change across radiation doses. "Radiation metabolomics," the application of metabolomic analysis to the field of radiobiology, promises to increase our understanding of cellular responses to stressors such as radiation.

Transient dominance in a central African rain forest

The large-crowned emergent tree Microberlinia bisulcata dominates rain forest groves at Korup National Park, Cameroon, along with two codominants, Tetraberlinia bifoliolata and T. korupensis. M. bisulcata has a pronounced modal size frequency distribution around 110 cm stem diameter: its recruitment potential is very poor. It is a long-lived light-demanding species, one of many found in African forests. Tetraberlinia species lack modality, are more shade tolerant, and recruit better. All three species are ectomycorrhizal. M. bisulcata dominates grove basal area, even though it has similar numbers of trees (≥50 cm stem diameter) as each of the other two species. This situation presented a conundrum that prompted a long-term study of grove dynamics. Enumerations of two plots (82.5 and 56.25 ha) between 1990 and 2010 showed mortality and recruitment of M. bisulcata to be very low (both rates 0.2% per year) compared with Tetraberlinia (2.4% and 0.8% per year), and M. bisulcata grows twice as fast as the Tetraberlinia. Ordinations indicated that these three species determined community structure by their strong negative associations while other species showed almost none. Ranked species abundance curves fitted the Zipf-Mandelbrot model well and allowed “overdominance” of M. bisulcata to be estimated. Spatial analysis indicated strong repulsion by clusters of large (50 to <100 cm) and very large (≥100 cm) M. bisulcata of their own medium-sized (10 to <50 cm) trees and all sizes of Tetraberlinia. This was interpreted as competition by M. bisulcata increasing its dominance, but also inhibition of its own replacement potential. Stem coring showed a modal age of 200 years for M. bisulcata, but with large size variation (50–150 cm). Fifty-year model projections suggested little change in medium, decreases in large, and increases in very large trees of M. bisulcata, accompanied by overall decreases in medium and large trees of Tetraberlinia species. Realistically increasing very-large-tree mortality led to grove collapse without short-term replacement. M. bisulcata most likely depends on climatic events to rebuild its stands: the ratio of disturbance interval to median species' longevity is important. A new theory of transient dominance explains how M. bisulcata may be cycling in abundance over time and displaying nonequilibrium dynamics.

Is Our Business Family-Centered?

Human Services agencies often claim to be family-centered, but continue to implement “Service Integration” in a way that supports their mission rather than supporting families. David Berns, guest editor for this issue of the Journal of Family Strengths, presents a framework for redefining the role of governmental agencies beyond their day-to-day delivery of services to one that prevents the need for more intrusive and more costly interventions. Under this philosophy, agencies must consider how families functioned before they requested assistance, and how they will function if services are not successful. By taking the time to truly understand a family’s needs, caseworkers often discover that they may need a service for which they are not eligible and may be eligible for services that they don’t want or need. Instead of focusing entirely on what their agency can do for the family, caseworkers should consider all types of support that might produce better results. Families often need support from friends and communities rather than, or in addition to, a formalized service. Facilitating natural supports in the community may prevent the need for a governmental program. It is only when basic supports break down that families must use ever more intensive and costly programs. The author gives examples of how this framework is guiding the redesign of the TANF Program in Washington, D.C.

Foreign aid : questions on the Central American regional program need to be resolved : report to the Honorable Patrick Leahy, United States Senate /

"B-221422"--P. [1].

Central America aid : status of the Trade Credit Insurance Program : fact sheet for the Honorable Patrick Leahy, U.S. Senate /

"B-221422"--1st. prelim. p.