The chronic kidney disease outcomes and practice patterns study Brazil (CKDopps-Brazil): Design, data and methodology

Introduction: The chronic kidney disease outcomes and practice patterns study (CKDopps) is an international observational, prospective, cohort study involving patients with chronic kidney disease (CKD) stages 3-5 [estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2, with a major focus upon care during the advanced CKD period (eGFR < 30 ml/min/1.73 m2)]. During a 1-year enrollment period, each one of the 22 selected clinics will enroll up to 60 advanced CKD patients (eGFR < 30 ml/min/1.73 m2 and not dialysis-dependent) and 20 earlier stage CKD patients (eGFR between 30-59 ml/min/1.73 m2). Exclusion criteria: age < 18 years old, patients on chronic dialysis or prior kidney transplant. The study timeline include up to one year for enrollment of patients at each clinic starting in the end of 2013, followed by up to 2-3 years of patient follow-up with collection of detailed longitudinal patient-level data, annual clinic practice-level surveys, and patient surveys. Analyses will apply regression models to evaluate the contribution of patient-level and clinic practice-level factors to study outcomes, and utilize instrumental variable-type techniques when appropriate. Conclusion: Launching in 2013, CKDopps Brazil will study advanced CKD care in a random selection of nephrology clinics across Brazil to gain understanding of variation in care across the country, and as part of a multinational study to identify optimal treatment practices to slow kidney disease progression and improve outcomes during the transition period to end-stage kidney disease.

They Do Things Differently There. Essays on Cultural History

This collection of Finnish essays in cultural history will be revelatory for anglophone readers. Pioneering in the study of cultural history as early as the nineteenth century, by the 1930s Finnish scholars already deployed the broad conception of 'culture' as embracing 'everyday life' that is usually thought of as emerging in the work of Raymond Williams decades later. These essays emanate from the Department of Cultural History, established at the University of Turku in 1972, and its partner department at the University of Lapland. The collection signals new genealogies of cultural historiography in general, and in its distinctively Finnish inflections.

A reação da elite política incumbente na abertura democrática brasileira

RESUMOEste artigo analisa um dos possíveis canais através dos quais as elites incumbentes alinhadas com a ditadura brasileira foram capazes de reter o seu poder político durante a democratização na década de 1980. Com base em dados do PNAD e resultados de eleições legislativas, verificamos primeiro que os eleitores analfabetos que viviam nos estados que foram dominados pelo partido de elite durante a ditadura tinham uma probabilidade maior de se registar para votar do que aqueles que viviam em outros estados. Investigamos então se esta correlação positiva representa uma reação das elites incumbentes a fim de manter o seu poder político através da manipulação do eleitor ou se representa uma reação destes eleitores, a fim de tirar o poder das oligarquias. Constatamos que, em estados dominados pelo partido de elite, os analfabetos apresentaram maior probabilidade de estarem politicamente desinteressados e desinformados. Nossos resultados sugerem que uma reação politicamente motivada a partir desta população é implausível.

1969 memo

Memo from Bruce Scott to Terry O'Malley regarding Lightning Fastener Company Limited and Time Magazine.

2004-05 Board of Trustees

The 2004-2005 Board of Trustees. Pictured here from left to right are: Front Row - Val Fleming; Dr. Patricia Teal; Wendy Staff; Dr. Norris Walker, Chair; Dr. David Atkinson, President and Vice Chancellor; Dr. Val Jaeger; Donna Scott; and Steven Lalinovich. Middle Row - Mike Farrell, Secretary to the University; Rudi Kroeker; Brandon Larry, President, Brock University Students' Union; Dr. Terry Boak, Vice-President, Academic and Provost; Mitzi Banders; Geeta Powell; Dr. Sid Segalowitz; Tom Gauld; Karin Jahnke-Haslam; and Dr. Mohammed Dore. Back Row - David Edwards, Immediate Past Chair; Bruce Wormald; Willy Heldbuechel, Vice-Chair; Brad Clarke; David Howes, Vice-Chair; Mark Steinman; Peter Partridge; Michael Sidenberg; Angelo Nitsopoulos; Steven Pillar, Vice President, Finance and Administration; Ron Dubien, Chief Information Officer. Absent from photo - Dr. Raymond Moriyama, Chancellor; Eleanor Ross; Jagoda Pike; Dr. Mary Frances Richardson; and Nick Brown.

Board of Trustees

Left to Right in clockwise fashion (Seated) B.P.R. Newman, C. Bruce Hill, Alan J. Earp (Provost), I.D. Buchanan, W.J. Marshall, Patrick Beard, H.C. Blenkhorn, H.W.M. Smith, Dr. James A. Gibson (President), D.W. Lathrop (69/70 chairman), E.R. Davey (68/69 chairman), Dr. C.A. Sankey (Chancellor), E.E. Mitchelson (Secretary), Dan Biggar, Mrs. J.J. Bench, M.L. Stwart, W.D. Chisholm, W.A. Thomas Left to Right (Standing) R.M. Schmon (Vice Chairman 69/70), E.S. Howard (Vice Chairman 69/70), S.S. MacInnes, QC (Vice Chairman 69/70)

Founders Committee

Members of the Founders' Committee. Pictured here in a clockwise fashion from the left are: R. L. Hearn, W. J. Freeman, M. A. Chown, M. L. Swart, C. Bruce Hill, C. B. Slemon, Dr. James A. Gibson, D. G. Willmot, J .M. Trott, A. C. Rae, W. B. C. Burgoyne, E. S. Howard, L. R. Williams, S. J. Leishman, E. J. Barbeau, and E. R. Davey. Missing from the photo were: W. B. Gunning, W. S. Martin, C. W. Morehead, and B. P. R. Newman.

General Vanier Chatting

General Vanier takes a moment to talk with C. Bruce Hill, Chairman of Brock University Founding Fund, during the Official Opening on October 19, 1964. From left to right: C. Bruce Hill, and General Vanier.

Men's Basketball Team (1988-89)

Coach: Garney Henley Team (Alphabetically): Bruce Adams, Frank Capretta, Kevin Farrow, David Dennis, Rob Demott, Brian Hayden, Peter Kaija, Steve Kolenko, Leacoft Panton, Kevin Rome, Kevin Stevinson, Glen Tone, Moe Willoughby

1969-70 Hockey Team

1969-71 Brock Generals Hockey team. Members from left to right - Back row: Tom Kearney (Trainer), Al Kellogg (Coach), John Hull, Craig Morrison, Gregg Law, Frank Mucci, Dale Andreas, Eric Stevens, Serge Girrard, John Clarey, Wayne Kenyon, Reg Egilsson, Dusty Papke, Randy Oiling (Manager). Front row: Ron Powel, Barry Hopkins, Bruce Wormald, Miller Hicks, Fred Carter, Mike Nicholson, Dick Overholt, Chris Shott. Missing: John O'Brien, Barry Elliot.

Getting Off the Water

Brock's Junior Varsity crew of '76 pictured looking appropriately worn out after practice. Their shirts read "Brock Crew '76: Up Y'Oars" Cox: Kari Syri, Stroke: Ed Cooling, Ralph Martens, Paul Kivell, Don Rickers, Sean Stackwood, Clark Wochis, Jack Pyke, Bow: Bruce Petrie, Coach (the leg on the boat): Tony Biernacki.

Validation of ice skating protocol to predict aerobic power in hockey players

Validation ofan Ice Skating Protocol to Predict Aerobic Power in Hockey Players In assessing the physiological capacity of ice hockey players, researchers have often reported the outcomes from different anaerobic skate tests, and the general physical fitness of participants. However, with respect to measuring the aerobic power of ice hockey players, few studies have reported a sport-specific protocol, and currently there is a lack of cohort-specific information describing aerobic power based on evaluations using an on-ice protocol. The Faught Aerobic Skating Test (FAST) uses an on-ice continuous skating protocol to induce a physical stress on a participant's aerobic energy system. The FAST incorporates the principle of increasing workloads at measured time intervals during a continuous skating exercise. Regression analysis was used to determine the estimate of aerobic power within gender and age level. Data were collected on 532 hockey players, (males=384, females=148) ranging in age between 9 and 25 years. Participants completed a laboratory test to measure aerobic power using a modified Bruce protocol, and the on-ice FAST. Regression equations were developed for six male and female, age-specific cohorts separately. The most consistent predictors were weight and final stage completed on the FAST. These results support the application of the FAST to estimate aerobic power among hockey players with R^ values ranging from 0.174 to 0.396 and SEE ranging from 5.65 to 8.58 ml kg' min'' depending on the cohort. Thus we conclude that FAST to be an accurate predictor of aerobic power in age and gender-specific hockey playing cohorts.

Reactivity characteristics of cytochrome c, cytochrome oxidase and the electrostatic cytochrome c - cytochrome oxidase complex /

The mechanism whereby cytochrome £ oxidase catalyses elec-. tron transfer from cytochrome £ to oxygen remains an unsolved problem. Polarographic and spectrophotometric activity measurements of purified, particulate and soluble forms of beef heart mitochondrial cytochrome c oxidase presented in this thesis confirm the following characteristics of the steady-state kinetics with respect to cytochrome £: (1) oxidation of ferrocytochrome c is first order under all conditions. -(2) The relationship between sustrate concentration and velocity is of the Michaelis-Menten type over a limited range of substrate. concentrations at high ionic strength. (3) ~he reaction rate is independent from oxygen concentration until very low levels of oxygen. (4) "Biphasic" kinetic plots of enzyme activity as a function of substrate concentration are found when the range of cytochrome c concentrations is extended; the biphasicity ~ is more apparent in low ionic strength buffer. These results imply two binding sites for cytochrome £ on the oxidase; one of high affinity and one of low affinity with Km values of 1.0 pM and 3.0 pM, respectively, under low ionic strength conditions. (5) Inhibition of the enzymic rate by azide is non-c~mpetitive with respect to cytochrome £ under all conditions indicating an internal electron transfer step, and not binding or dissociation of £ from the enzyme is rate limiting. The "tight" binding of cytochrome '£ to cytochrome c oxidase is confirmed in column chromatographic experiments. The complex has a cytochrome £:oxidase ratio of 1.0 and is dissociated in media of high ionic strength. Stopped-flow spectrophotometric studies of the reduction of equimolar mixtures and complexes of cytochrome c and the oxidase were initiated in an attempt to assess the functional relevance of such a complex. Two alternative routes -for reduction of the oxidase, under conditions where the predominant species is the £ - aa3 complex, are postulated; (i) electron transfer via tightly bound cytochrome £, (ii) electron transfer via a small population of free cytochrome c interacting at the "loose" binding site implied from kinetic studies. It is impossible to conclude, based on the results obtained, which path is responsible for the reduction of cytochrome a. The rate of reduction by various reductants of free cytochrome £ in high and low ionic strength and of cytochrome £ electrostatically bound to cytochrome oxidase was investigated. Ascorbate, a negatively charged reagent, reduces free cytochrome £ with a rate constant dependent on ionic strength, whereas neutral reagents TMPD and DAD were relatively unaffected by ionic strength in their reduction of cytochrome c. The zwitterion cysteine behaved similarly to uncharged reductants DAD and TI~PD in exhibiting only a marginal response to ionic strength. Ascorbate reduces bound cytochrome £ only slowly, but DAD and TMPD reduce bound cytochrome £ rapidly. Reduction of cytochrome £ by DAD and TMPD in the £ - aa3 complex was enhanced lO-fold over DAD reduction of free £ and 4-fold over TMPD reduction of free c. Thus, the importance of ionic strength on the reactivity of cytochrome £ was observed with the general conclusion being that on the cytochrome £ molecule areas for anion (ie. phosphate) binding, ascorbate reduction and complexation to the oxidase overlap. The increased reducibility for bound cytochrome £ by reductants DAD and TMPD supports a suggested conformational change of electrostatically bound c compare.d to free .£. In addition, analysis of electron distribution between cytochromes £ and a in the complex suggest that the midpotential of cytochrome ~ changes with the redox state of the oxidase. Such evidence supports models of the oxidase which suggest interactions within the enzyme (or c - enzyme complex) result in altered midpoint potentials of the redox centers.

An investigation of geological and geochemical characteristics of late-Quaternay sediments in the Georgian Bay Region, Southern Ontario

Core samples of postglacial sediments and sediment surface samples from Shepherd Lake on the Bruce Peninsula, Harts Lake on the Canadian Shield, and two cores from Georgian Bay (core P-l in the western deep part and core P-7 in the eastern shallow part) have been analyzed for pH, grain size distribution, water content, bulk density, loss on ignition at 4500C and 11000 C, major oxides (Si02 ,A1203,!FeO,MgO,CaO, Na20,K20,Ti02 ,MnO and P205) and trace elements (Ba,Zr,Sr,y,S, Zn,Cu,Ni,Ce and Rb). The sediment in Georgian Bay are generally fine grained (fine silt to very fine silty clay) and the grain size decreases from the Canadian Shield (core p-7) towards the Bruce Peninsula (core P-l) along the assumed direction of sediment transport. This trend coincides with a decrease in sorting coefficient and an increase in roundness. Other physical characteristics, such as water content, bulk density and loss on ignition are positively correlated with the composition of sediments and their compaction, as well as with the energy of the depositional environment. Analyses of sediment surface samples from Shepherd Lake and Harts Lake indicate the influence of bedrock and surficial deposits in the watershed on pH condition that is also influenced by the organic matter content and probably I ! I man's activities. Organic matter content increases significantly in the surface sediment in these small lakes as a result of either natural eutrophication or anthropogenic organic loading. The extremely high organic matter content in Shepherd Lake sediment indicates rapid natural eutrophication in this closed basin and high biological productivity during postglacial time, probably due to high nutrient levels and shallow depth. The chemical composition of the Canadian Shield bedrock is positively correlated with the chemical characteristics of predominantly inorganic lake sediments that were derived from the Shield rocks by glacial abrasion and by postglacial weathering and erosion of both bedrock and surficial deposits. High correlation coefficients were found between organic matter in lake sediments and major oxides (Si02,AI203,.~FeO, MgO,CaO,K20 and MnO) , as well as some trace elements (Ba,Y, S,Zn,Cu,Ni and Rb). The chemical composition of sediments in Harts Lake and core P-7 in Georgian Bay on the Canadian Shield differs from the chemistry of sediments in Shepherd Lake and core P-l in Georgian Bay on the Bruce Peninsula. The difference between cores P-l and P-7 is indicated by values of Si02 , AI203 ,:LFeo,Mgo,CaO,Ba,Zr,Sr,y and S, and also by the organic matter content. This study indicates that the processes of sediment transport, depositional environment, weathering of the rocks and surficial deposits in the watershed, as well as chemical composition of source rocks all affect the chemical characteristics of lake sediments. The stratigraphic changes and variations in lake sediment chemistry with regard to major oxides, trace elements, and organic matter content are probably related to the history of glacial and postglacial lake stages of the Georgian Bay Region and, therefore, the geochemical data can make a useful contribution to a better understanding of the Late-Quaternary history of the Great Lakes.