936 resultados para BETA-2-GLYCOPROTEIN-I
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La segunda obra con portada y pag. propia. -- Múltiples errores de pág. -- Texto con apostillas marginales.
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Vol. 2-4, pt. 1 have also special t.p.; v. 4, pt. 2 not published
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In Cyrillic characters
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t. 1. Liricheskīi͡a stikhotvorenīi͡a (1812-1817) -- t. 2. Liricheskīi͡a stikhotvorenīi͡a (1818-1820). Ruslan i Li͡udmila (1817-1820). Kavkazskīĭ Pli͡ennik (1820-1821) -- t. 3. Liricheskīi͡a stikhotvorenīi͡a (1821-1824). Bratʹi͡a razboĭniki (1821-1822). Otryvki iz poėmy (1822). Bakhchisaraĭskīĭ fontan (1822-1823). T͡Sygany (1823-1824).
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t. 1. St︠s︡eny iz narodnago byta -- St︠s︡eny iz kupecheskago byta -- St︠s︡eny iz gorodskoĭ zhizni -- Monologi -- t. 2. Ocherki i razskazy -- Dramaticheskīe ėti︠u︡dy -- Podrazhanīi︠a︡ starinnoĭ pisʹmennosti -- Ocherki iz istorīii teatra -- Otryvki iz vospominanīĭ.
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The Illinois Department of Transportation (IDOT) has initiated the Illinois Route 2 Phase I Study. The study will examine the transportation needs of and solutions for the corridor through an extensive public involvement process. The study area is located in Winnebago County, extending approximately 2.0 miles from north of Auburn Street on the south to north of Riverside Blvd. on the north, all within the City of Rockford, Illinois.
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"Iz zhurnala "Trudy Kīevskoĭ dukh. adademīi za 1895-1902 god."
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Vol. 2 lacks special t.p.
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ch. 1. Neschastnye -- ch. 2 Vinovatye i obvinennye -- ch. 3. Politicheskīe i gosudarstvennye prestupniki
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Volumes published in 1875-1880 are labelled "chastʹ I" and "chastʹII".
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t. 1. Krestʹi︠a︡nskīĭ vopros v XVIII i pervoĭ chetverti XIX vi︠e︡ka -- t. 2. Krestʹi︠a︡nskīĭ vopros v t︠s︡arstvovanīe imperatora Nikolai︠a︡.
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vyp. 1. Pisʹma iz Srednikh Veliko-Rossīĭskikh gubernīĭ za 1867 god -- vyp. 2. Na i︠u︡go-zapad Rossīi 1869-ĭ god.
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Includes bibliographical references and index.
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beta2-Laminin is important for the formation of neuromuscular junctions in vertebrates. Previously, we have inactivated the gene that encodes for beta2-laminin in mice and observed predominantly prejunctional structural defects. In this study, we have used both intra- and extracellular recording methods to investigate evoked neurotransmission in beta2-laminin-deficient mice, from postnatal day 8 (P8) through to day 18(P18). Our results confirmed that there was a decrease in the frequency of spontaneous release, but no change in the postjunctional response to such release. Analysis of evoked neurotransmission showed an increase in the frequency of stimuli that failed to elicit an evoked postjunctional response in the mutants compared to litter mate controls, resulting in a 50% reduction in mean quantal content at mutant terminals. Compared to littermate controls, beta2-laminin-deficient terminals showed greater synaptic depression when subjected to high frequency stimulation. Furthermore, the paired pulse ratio of the first two stimuli was significantly lower in beta2-laminin mutant terminals. Statistical analysis of the binomial parameters of release showed that the decrease in quantal content was due to a decrease in the number of release sites without any significant change in the average probability of release. This suggestion was supported by the observation of fewer synaptic vesicle protein 2 (SV2)-positive varicosities in beta2-laminin-deficient terminals and by ultrastructural observations showing smaller terminal profiles and increased Schwann cell invasion in beta2-laminin mutants; the differences between beta2-laminin mutants and wild-type mice were the same at both P8 and P18. From these results we conclude that beta2-laminin plays a role in the early structural development of the neuromuscular junction. We also suggest that transmitter release activity may act as a deterrent to Schwarm cell invasion in the absence of beta2-laminin.
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A competitive RT-PCR assay was used to quantify the expression of the GABA(A) receptor beta(1), beta(2) and beta(3) isoform mRNA transcripts in the superior frontal cortex and motor cortex of 21 control and 22 alcoholic cases. A single set of primers was designed that permitted amplification of all three transcripts and the internal standard simultaneously; differentiation of the individual transcripts was achieved by restriction enzyme digestion. Construction of a standard curve, using the internal standard and a concentration range of beta(2) cRNA-enabled quantitation of mRNA expression levels. No significant difference in mRNA expression was found between the control and alcoholic case groups in either the superior frontal or motor cortex for the beta(2) or beta(3) isoforms. A significant interaction was found between isoform and area, although, the two case groups did not partition on this measure. The interaction was due to a significant difference between superior frontal and motor cortex for the beta(3) isoform; this regional comparison was not significant for beta(2) mRNA. Age at death and post-mortem delay (PMD) had no significant effect on beta mRNA expression in either case group in either region. A beta(1) signal could not be detected in the RT-PCR assay. (C) 2004 Elsevier Ltd. All rights reserved.