991 resultados para Timur, 1336-1405
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Banco del conocimiento
The role of cyclic nucleotides in modulation of crayfish neuromuscular junctions by a neuropeptide /
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DF2, a heptapeptide, is a member of the family of FMRFamide-like peptides and has been shown to increase the amount of transmitter released at neuromuscular junctions of the crayfish, Procambarus clarkit Recent evidence has shown that protein kinase C (PKC), calcium/calmodulin-dependent protein kinase II (CaMKII) and the cAMPdependent protein kinase (PKA) play a role in the neuromodulatory pathway of DF2. The involvement of these kinases led to the prediction that a G-protein-coupled receptor (GPCR) is activated by DF2 due to the role that each kinase plays in traditional GPCR pathways seen in other organisms and in other cells. G-proteins can also act on an enzyme that generates cyclic guanosine monophosphate (cGMP) which mediates its effects through a cGMP-dependent protein kinase (PKG). This thesis addresses the question of whether or not DF2's effects on synaptic transmission in crayfish are mediated by the cyclic nucleotides cAMP and cGMP. The effects of DF2 on synaptic transmission were examined using deep abdominal extensor muscles of the crayfish Procambarus clarkii. An identified motor neuron was stimulated, and excitatory post-synaptic potentials (EPSPs) were recorded in abdominal extensor muscle LI . A number of activators and inhibitors were used to determine whether or not cAMP, PKA, cGMP and PKG mediate the effect of this peptide. Chemicals that are known to activate PKA (Sp-cAMPS) and/or PKG (8-pCPTcGMP) mimic and potentiate DF2's effect by increasing EPSP amplitude. Inhibitors of either PKA (Rp-cAMPS) or PKG (Rp-8-pCPT-cGMPS) block a portion of the increase in EPSP amplitude induced by the peptide. When both kinase inhibitors are applied simultaneously, the entire effect of DF2 on EPSPs is blocked. The PKG inhibitor blocks the effects of a PKG activator but does not alter the effect of a PKA activator on EPSP amplitude. Thus, the PKG inhibitor appears to be relatively specific for PKG. A trend in the data suggests that the PKA inhibitor blocks a portion of the response elicited by the PKG activator. Thus, the PKA inhibitor may be less specific for PKA. Phosphodiesterase inhibitors, which are known to inhibit the breakdown of cAMP (IBMX) and/or cGMP (mdBAMQ), potentiate the effect of the peptide. These results support the hypothesis that cAMP and cGMP, acting through their respective protein kinase enzymes, mediate the ability of DFi to increase transmitter output.
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There are a considerable number of programs and agencies that count on the existence of a unique relationship between nature and human development. In addition, there are significant bodies of literature dedicated to understanding developmentally focused nature-based experiences. This research project was designed to flirther the understanding of this phenomenon. Consequently, the purpose of this research endeavour was to discover the essence ofthe intersection ofpersonal transformation and nature-based leisure, culminating in a rich and detailed account of this otherwise tacit phenomenon. As such, this research built on the assumption of this beneficial intersection of nature and personal transformation and contributes to the understanding ofhow this context is supporting or generating of selfactualization and positive development. Heuristic methods were employed because heuristics is concerned with the quality and essence of an experience, not causal relationships (Moustakas, 1990). Heuristic inquiry begins with the primary researcher and her personal experience and knowledge of the phenomenon. This study also involved four other coresearchers who had also experienced this phenomenon intensely. Co-researchers were found through purposeful and snowball sampling. Rich narrative descriptions of their experiences were gathered through in-depth, semi-structured interviews, and artifact elicitation was employed as a means to get at co-researchers' tacit knowledge. Each coresearcher was interviewed twice (the first interview focused on personal transformation, the second on nature) for approximately four and a half hours in total. Transcripts were read repeatedly to discern patterns that emerged from the study of the narratives and were coded accordingly. Individual narratives were consolidated to create a composite narrative of the experience. Finally, a creative synthesis was developed to represent the essence of this tacit experience. In conclusion the essence of the intersection of nature-based leisure and personal transformation was found to lie in the convergence of the lived experience of authenticity. The physical environment of nature was perceived and experienced to be a space and context of authenticity, leisure experiences were experienced as an engagement of authenticity, and individuals themselves encountered a true or authentic self that emanated from within. The implications of these findings are many, offering suggestions, considerations and implications from reconsidered approaches to environmental education to support for selfdirected human development.
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Tesis (Maestría en Ciencias de la Administración con Especialidaden Finanzas) UANL
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Tesis (Maestria en Enfermería con Especialidad en Salud Mental y Psiquiatría) UANL
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La jurisprudence portant sur les droits ancestraux ou issus de traités des peuples autochtones fait peu de place aux ordres juridiques antérieurs à la création de colonies françaises ou anglaises. Les tribunaux s’accordent d’ailleurs une très grande discrétion dans l’utilisation de ces normes ; ils assurent également la prééminence du système juridique canadien. Ils ménagent toutefois un meilleur accueil aux récits traditionnels qui sont susceptibles de constituer des éléments de preuve. Par ailleurs, antérieurement au XIXe siècle, les peuples autochtones jouissent de droits de nature internationale ; les traités conclus avec eux résultent souvent de négociations orales. Les droits qui en résultent sont maintenant constitutionnalisés, ce qui écarte certaines conceptions de l’époque comme celle voulant que les gouvernements étaient libres de faire abstraction de ces engagements. Par ailleurs, les litiges actuels soulèvent des questions qui n’étaient pas susceptibles de se poser il y a deux siècles. Dans ces conditions, l’histoire ne peut fournir de réponses définitives ou univoques.
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A novel slope -strip feeding technique for a microstrip antenna is presented in order to achieve a broad bandwidth. The experimental results show that the optimal bandwidth attained is 53.4% for less than -10-dB return loss
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Vocabulario básico de los principales campos semánticos que se abordan en la etapa de Educación Infantil, así como en la educación especial, desde una perspectiva del multisignificado funcional..
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Los relatos seleccionados del I Certamen Nacional, están disponibles en REDINED, a texto completo.
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We investigate the differences --- conceptually and algorithmically --- between affine and projective frameworks for the tasks of visual recognition and reconstruction from perspective views. It is shown that an affine invariant exists between any view and a fixed view chosen as a reference view. This implies that for tasks for which a reference view can be chosen, such as in alignment schemes for visual recognition, projective invariants are not really necessary. We then use the affine invariant to derive new algebraic connections between perspective views. It is shown that three perspective views of an object are connected by certain algebraic functions of image coordinates alone (no structure or camera geometry needs to be involved).
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Resumen basado en la publicación
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Comprobar el Inglés que pueden aprender los escolares, número de vocablos, dificultades de pronunciación, estructuras gramaticales más adecuadas, extensión de los diálogos, y diseñar un corpus de actividades, recursos, y técnicas de evaluación. En colaboración continuada: 5 colegios nacionales y privados con 1600 alumnos. Con una colaboración parcial: 6 colegios nacionales y privados con 630 alumnos, tanto unos como otros son de Granada capital. Elaboración de materiales didácticos del proyecto Junior English 1976, reformulados cada año. Realización de una evaluación oral continuada y una evaluación escrita con diferentes pruebas cada bimestre. Presentan el material del alumno, las evaluaciones, y los resultados. Aplicación del proyecto Junior English 1976. Pruebas de control para cada actividad, orales y escritas: test de vocabulario, pronunciación ,'Idioms' y estructuras. Media, desviación típica, homogeneidad de los grupos, fiabilidad de la prueba, índices de dificultad y discriminación. Demuestran en cada uno de los tres niveles que, tanto contenidos como objetivos, actividades y evaluaciones, son conseguidas y adecuadas. Los índices de fiabilidad bastante aceptables de algunas pruebas , permiten su estandarización. Desarrollan lo que debe enseñarse a los 6,7,8 y 9 años. Conjunto de material didáctico y juegos originales y motivadores. Presenta ventajas el estudio del idioma en la infancia, siendo beneficioso para las demás áreas educativas, y posteriormente en la segunda etapa de EGB. Podemos iniciar la lectura de una segunda lengua a partir de tercero de EGB.
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Calendari de l'any 2009 dedicat al consum responsable
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gvSIG Mobile, la versión de gvSIG para dispositivos móviles presenta su nueva versión que incluye las esperadas funcionalidades de creación de nuevas entidades geográficas y utilización de formularios personalizados para edición de datos, además de nuevos formatos de datos vectoriales (GML, KML, GPX) y sistemas de referencia. Funcionalidades que se suman a las capacidades de visor de cartografía (ECW, SHP, WMS) y sistema de localización mediante GPS que ya posee. gvSIG Mobile está siendo desarrollado por Prodevelop, la Universitat de València e Iver para la Conselleria d’Infraestructures i Transport de la Generalitat Valenciana y se distribuye con una licencia GPL