Comportamento de cultivares de feijoeiro e de milho verde em cultivo solteiro e consorciado

Pós-graduação em Agronomia - FEIS

Diagnóstico das infecções relacionadas a cateter em recém-nascidos e epidemiologia molecular dos Staphylococcus spp. isolados

Pós-graduação em Biologia Geral e Aplicada - IBB

Periostin as a modulator of chronic cardiac remodeling after myocardial infarction

OBJECTIVE: After acute myocardial infarction, during the cardiac repair phase, periostin is released into the infarct and activates signaling pathways that are essential for the reparative process. However, the role of periostin in chronic cardiac remodeling after myocardial infarction remains to be elucidated. Therefore, the objective of this study was to investigate the relationship between tissue periostin and cardiac variables in the chronic cardiac remodeling induced by myocardial infarction. METHODS: Male Wistar rats were assigned to 2 groups: a simulated surgery group (SHAM; n = 8) and a myocardial infarction group (myocardial infarction; n = 13). After 3 months, morphological, functional and biochemical analyses were performed. The data are expressed as means±SD or medians (including the lower and upper quartiles). RESULTS: Myocardial infarctions induced increased left ventricular diastolic and systolic areas associated with a decreased fractional area change and a posterior wall shortening velocity. With regard to the extracellular matrix variables, the myocardial infarction group presented with higher values of periostin and types I and III collagen and higher interstitial collagen volume fractions and myocardial hydroxyproline concentrations. In addition, periostin was positively correlated with type III collagen levels (r = 0.673, p = 0.029) and diastolic (r = 0.678, p = 0.036) and systolic (r = 0.795, p = 0.006) left ventricular areas. Considering the relationship between periostin and the cardiac function variables, periostin was inversely correlated with both the fractional area change (r = -0.783, p = 0.008) and the posterior wall shortening velocity (r = -0.767, p = 0.012). CONCLUSIONS: Periostin might be a modulator of deleterious cardiac remodeling in the chronic phase after myocardial infarction in rats.

Coagulase-negative staphylococci strains resistant to oxacillin isolated from neonatal blood cultures

Coagulase-negative staphylococci (CoNS) are the microorganisms most frequently isolated from clinical samples and are commonly found in neonatal blood cultures. Oxacillin is an alternative treatment of choice for CoNS infections; however, resistance to oxacillin can have a substantial impact on healthcare by adversely affecting morbidity and mortality. The objective of this study was to detect and characterise oxacillin-resistant CoNS strains in blood cultures of newborns hospitalised at the neonatal ward of the University Hospital of the Faculty of Medicine of Botucatu. One hundred CoNS strains were isolated and the mecA gene was detected in 69 of the CoNS strains, including 73.2% of Staphylococcus epidermidis strains, 85.7% of Staphylococcus haemolyticus strains, 28.6% of Staphylococcus hominis strains and 50% of Staphylococcus lugdunensis strains. Among these oxacillin-resistant CoNS strains, staphylococcal cassette chromosome mec (SCCmec) type I was identified in 24.6%, type II in 4.3%, type III in 56.5% and type IV in 14.5% of the strains. The data revealed an increase in the percentage of CoNS strains isolated from blood cultures from 1991-2009. Furthermore, a predominant SCCmec profile of the oxacillin-resistant CoNS strains isolated from neonatal intensive care units was identified with a prevalence of SCCmec types found in hospital-acquired strains.

Verificação da dureza de gessos em função da compatibilidade com materiais de moldagem à base de borracha

Currently the most widespread material used in dies is gypsum that together with its simple technique has very satisfactory mechanical, chemical and physical properties. However, its compactibility with the impression materials can compromise the die surface quality. In our work, we studies the hardness of the two gypsum types: Type III (die stone) and type IV (improved die stone), as well as the influence of the contact with three types of impression materials: polymerized silicone for condensation (Xantopren), polysulfide (Permlastic) and polymerized silicone by addition (Provil). As comparison parameter gypsum was used in contact with a glass surface…(Complete abstract click electronic access below)

Desenvolvimento de sistemas líquido cristalinos contendo Ac-WAhx-KTTKS para o tratamento do envelhecimento cutâneo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Scale morphology of Prochilodus lineatus with emphasis on the scale epithelium

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Assessment of the Correlation Between Insertion Torque and Resonance Frequency Analysis of Implants Placed in Bone Tissue of Different Densities

The primary stability of dental implants is fundamental for osseointegration. Therefore, this study aimed to assess the correlation between insertion torque (IT) and resonance frequency analysis (RFA) of implants placed in mandibles and maxillas of different bone densities. Eighty dental implants were placed in maxillas and mandibles, and IT and the implant stability quotient (ISQ) were measured at the time of implant insertion. Bone density was assessed subjectively by the Lekholm and Zarb index. The type I and II densities were grouped together (group A)as were the type III and IV densities (group B). The IT in group A was higher (Student t test, P = .0013) than in group B (46.27 +/- 18.51 Ncm, 33.62 +/- 14.74 Ncm, respectively). The implants placed in group A showed higher ISQ (Student t test, P = .0004) than those placed in group B (70.09 +/- 7.50, 63.66 +/- 8.00, respectively). A significant correlation between IT and the ISQ value was observed for group A (Pearson correlation test; r = 0.35; P = .0213) and for group B (r = 0.37; P = .0224). Within the limitations of this study, it was possible to conclude that there is a correlation between IT and RFA of implants placed in mandibles and maxillas of different bone densities.

Comparative proteomic analysis reveals that T3SS, Tfp, and xanthan gum are key factors in initial stages of Citrus sinensis infection by Xanthomonas citri subsp citri

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Reduced susceptibility to vancomycin and biofilm formation in methicillin-resistant Staphylococcus epidermidis isolated from blood cultures

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Extracellular matrix remodeling of the testes through the male reproductive cycle in Teleostei fish

During the fish reproductive cycle, testes undergo morphological changes related to germinal epithelium and remodeling of extracellular matrix components (ECM). ECM is degraded mainly by action of matrix metalloproteinases (MMPs). Due to the natural renewal of ECM in fish testes, we choose Pimelodus maculatus to study remodeling of ECM throughout reproductive cycle, using picrosirius (to identify type I, II, III collagen) and reticulin (type III collagen), and to immunolocalize MT1-MMP (membrane type 1-matrix metalloproteinase) and MMP-2 in testis cells. Testes were classified in four reproductive phases: regenerating, development, spawning capable and regressing. Picrosirius and reticulin demonstrated a differential distribution of total collagen fibers during the reproductive cycle. Immunohistochemistry showed MT1-MMP only in acidophilic granulocyte cells mainly inside blood vessels, in connective tissue of capsule close to the germinal compartment, and also infiltrated in interstitial connective tissue. MMP-2 was detected in fibroblast and endothelial cells of interstitial and capsule blood vessels, in epithelial cells of capsule, and in acidophilic granulocyte cells at same description for MT1-MMP. The fish testes ECM were remodeled throughout reproductive cycle in according to morphophysiological alterations. During reproductive season (spawning capable), the interstitium increased in total collagen fibers (type I, II, III). After spermiation period (regression and regenerating), the amount of collagen fibers decreased in response to action of MMPs on collagen degradation and other interstitial components (not assessed in this study). MMPs seem to be indispensable components for natural cyclic events of ECM remodeling of fish testes and for guarantee tissue homeostasis throughout reproductive cycle.

Characterization of the clonal profile of MRSA isolated in neonatal and pediatric intensive care units of a University Hospital

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo morfométrico do canal do hipoglosso

The hypoglossal nerve (HN) is responsible for the intrinsic and extrinsic muscles of the tongue. Knowledge of this is extremely important because this nerve is responsible for tongue movement. HN paralysis can be associated to the disease itself in various zones in which the NH travels, mainly the hypoglossal canal (HC). Variations in shape of the hypoglossal canal have been pointed to as the cause of HN paralysis in several studies. Four hundred dried intact human skulls without sex or race identification, belonging to the Discipline of Anatomy of ICTSJC – UNESP were studied. Each canal was classified into types: type I (without division in the HC), type II (HC with low bone spike), type III (HC more than two projections bone), type IV (presence of complete bony bridge without dividing HC into two distinct canals) and type V (presence of bone bridge by dividing into two HC canals). HC was found in 100% of skulls studied in both side. Regarding types, we found 538 (67.25%) hypoglossal canal of type I (34%, right side and 33.25%, left side), 108 (13.5%) of type II (7.38%, right side, and 6.13%, left side), 60 (7.5%) hypoglossal canal of type III (3.5%, right side and 4.0%, left side) 84 (10.5%) of type IV (4.75%, right side and 5.75%, left side) and 5 (0.63%) of the type V (0.13%, right side and 0.5%, left side). We found 5 (0,63%) different HC and classified ourselves in type VI, VII and VIII. The average angle was 51,3º on right side and 50,25º on left side. Detailed knowledge of the anatomy of the CH supports professionals in interventions of bloody skull base and also in giving the correct diagnosis of the probable causes of paralysis of the hypoglossal nerve

Estudo do remodelamento da lâmina própria da laringe relacionado ao processo de senilidade

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo da atividade de água em co-produtos da indústria de sucos: sementes de maracujá, casca de laranja e cascas de manga

Pós-graduação em Engenharia e Ciência de Alimentos - IBILCE