Sweet's syndrome involoving the musculoskeletal system during treatment of promyelocytic leukemia with all-trans retinoic acid

Induction therapy of promyelocytic leukemia with all-trans retinoic acid is a standard therapy despite significant side-effects. The most important, the "retinoic acid syndrome", consists of a hyperinflammatory reaction with capillary leakage (edema, pleural, and pericardial effusion), infiltration of myeloid cells into internal organs and systemic signs of inflammation. We describe here two cases of another hyperinflammatory reaction during all-trans retinoic acid therapy, the Sweet's syndrome, consisting of infiltrates of the skin and internal organs by neutrophilic granulocytes. Fever, painful erythematous cutaneous plaques, prominent musculoskeletal involvement (myositis, fasciitis), a sterile pulmonary infiltration and intercurrent proteinuria characterized the clinical course of all-trans retinoic acid-associated Sweet's syndrome. Treatment with glucocorticoids led to resolution of the syndrome within 48 h. Three other cases of all-trans retinoic acid-associated Sweet's syndrome without involvement of internal organs, prominent on our cases, were published previously. Recognition of ATRA-associated Sweet's syndrome is of practical importance.

Sweet Puppies and Cute Babies: Perceptual Adaptation to Babyfacedness Transfers across Species

Infant faces are very salient stimuli. The Kindchenschema describes specific features that characterize a cute infant face. In this study we used a visual adaptation paradigm to investigate the universality of the perceptual properties of the Kindchenschema. In Experiment 1, twenty-four participants adapted to cute and less cute human infant faces and in Experiment 2, twenty-four new participants adapted to cute and less cute faces of puppy dogs. In both experiments the task was to assess the cuteness of subsequently presented human infant faces. The results revealed cuteness after-effects for human infant faces in both adaptation conditions, suggesting a common mechanism coding cuteness in human and non-human faces. This study provides experimental evidence for the universality of the well-described concept of the Kindchenschema.

Giant cellulitis-like Sweet Syndrome, a new variant of neutrophilic dermatosis

BACKGROUND Neutrophilic dermatoses comprise a wide spectrum of inflammatory diseases with overlapping features characterized histologically by the presence of an aseptic neutrophilic infiltrate in the epidermis, dermis, and/or hypodermis and are often associated with systemic inflammatory and neoplastic disorders. OBSERVATIONS We describe 3 patients with an unusual neutrophilic dermatosis characterized by relapsing episodes of fever, widespread infiltrated plaques with bullous appearance, and variable involvement of the arms, legs, abdomen, and/or trunk. Light microscopy studies showed marked edema of the papillary dermis with an inflammatory infiltrate consisting mainly of mature neutrophils. All 3 patients were morbidly obese, and workup revealed underlying cancer in 2 cases: myeloma and breast carcinoma. Management of the underlying disease resulted in long-term remission of the skin disease. CONCLUSIONS The clinicopathologic features in our 3 cases best correspond to a widespread giant cellulitis-like form of Sweet syndrome. Knowledge of this newly observed unusual variant of Sweet syndrome within the broad spectrum of neutrophilic diseases is important for its prompt and proper management.

The role of human-induced fire and sweet chestnut (Castanea sativa Mill.) cultivation on the long-term landscape dynamics of the southern Swiss Alps

Changes in fire occurrence during the last decades in the southern Swiss Alps make knowledge on fire history essential to understand future evolution of the ecosystem composition and functioning. In this context, palaeoecology provides useful insights into processes operating at decadal-to-millennial time scales, such as the response of plant communities to intensified fire disturbances during periods of cultural change. We provide a high-resolution macroscopic charcoal and pollen series from Guèr, a well-dated peat sequence at mid-elevation (832 m.a.s.l.) in southern Switzerland, where the presence of local settlements is documented since the late Bronze Age and the Iron Age. Quantitative fire reconstruction shows that fire activity sharply increased from the Neolithic period (1–3 episodes/1000 year) to the late Bronze and Iron Age (7–9 episodes/1000 year), leading to extensive clearance of the former mixed deciduous forest (Alnus glutinosa, Betula, deciduous Quercus). The increase in anthropogenic pollen indicators (e.g. Cerealia-type, Plantago lanceolata) together with macroscopic charcoal suggests anthropogenic rather than climatic forcing as the main cause of the observed vegetation shift. Fire and controlled burning were extensively used during the late Roman Times and early Middle Ages to promote the introduction and establishment of chestnut (Castanea sativa) stands, which provided an important wood and food supply. Fire occurrence declined markedly (from 9 to 5–6 episodes/1000 year) during late Middle Ages because of fire suppression, biomass removal by human population, and landscape fragmentation. Land-abandonment during the last decades allowed forest to partly re-expand (mainly Alnus glutinosa, Betula) and fire frequency to increase.

The Sweet Script: A Critical Analysis of American Sportswriting

This thesis analyzes the sportswriting genre as a form of personal essay. It explores the art over time through writers Red Smith, A.J. Liebling, Roger Angell, George Plimpton, Bart Giamatti, Frank Deford, and Rick Reilly, as well as anthologized writers from 2008 and blogs.

Mittheilungen über die Anbauversuche der süssen gelben und rothen Batate (Sweet batatas, Batatas edúlis Chois)

Vom Garteninspektor F. Jühlke

Bittere giftige Maniok, Cassava

Louise von Panhuys

Sweet Corn Cultivar Trial

The 2011 sweet corn cultivar trial evaluated 20 sugary enhanced (se) and synergistic (se/sh2) cultivars having bicolored kernels to identify good production and ear characteristics for local marketing or short-distance shipping.

Fundamentación del conjunto tractor-apero para la labor de surcado y su influencia en el consumo energético en cultivos de raíces y tubérculos

El cumplimiento de los objetivos agrotécnicos de los cultivos de raíces y tubérculos exige que la labor de surcado configure un caballón que permita el trabajo de los posteriores aperos que participan en las demás labores de cultivo. En la agricultura cubana se emplean diversos tipos de surcadores que difieren en las características de los elementos aporcadores. Este hecho afecta a la capacidad de trabajo del conjunto tractor-apero y por extensión en el consumo de combustible y el rendimiento del cultivo. El objetivo de este trabajo ha sido fundamentar el empleo del apero más adecuado para la labor de surcado en cultivos de raíces y tubérculos (patata, boniato, yuca) en Fluvisoles, teniendo en cuenta el comportamiento de las dimensiones y forma del caballón, cualidades tecnológicas explotativas del conjunto tractor-apero, consumo energético del proceso productivo y el rendimiento agrícola. Los tratamientos considerados estuvieron determinados por la utilización del surcador fertilizador IIMA-BALDAN 4.500 (T1), y los surcadores aporcadores SA-5 (T2) y SA-3 (T3). En los tres tratamientos se alcanzó un perfil de la sección transversal del caballón de configuración cóncavo-convexo. El surcador BALDAN logró el mejor comportamiento de los indicadores tecnológico-explotativos lo que se tradujo en la mayor capacidad de trabajo de 1,36 ha h-1 y el menor consumo de combustible de 5,38 L ha-1. Este mismo tratamiento proporcionó el mayor rendimiento medio de los cultivos superando en un 43,2% al del surcador SA-5 y en un 57,9% al del surcador SA-3. Desde el punto de vista energético T1, obtuvo una mejor eficiencia energética superior en un 43,5% a la del tratamiento T2, y en un 57,1% a la del tratamiento T3. ABSTRACT The achievement of agrotechnical objectives in the cultivation of roots and tubers demands the plow through activity creates a ridge to allow the work of subsequent farming tools participating in other cultivation works. In Cuban Agriculture various kinds of furrowers are used which differ in the characteristics of their earth up elements. This fact affects work capacity of the tractor-farming tool combination and by extension to fuel consumption and cultivation yield. The aim of this work has been to support the use of the most accurate farming tool in the plow through activity for the cultivation of roots and tubers (potato, sweet potato, cassava) in Fluvisoils, taking into account the behaviour of the ridge´s dimensions and shape, technologic-explotative qualities of the tractor-farming tool combination, energy consumption of the productive process and agricultural yield. The treatments considered were determined by the use of fertlizing furrower IIMA-BALDAN 4.500 (T1), and the earth up furrowers SA-5 (T2) and SA-3 (T3). During the three treatments a transverse section profile of the ridge under concave-convex configuration was obtained. The furrower BALDAN achieved the best behaviour of the technologic-explotative indicators, which was translated into the largest work capacity of 1,36 ha h-1 and the smallest fuel consumption of 5,38 L ha-1. This treatment also provided the biggest average yield of the cultivation, overcoming in a 43,2% the furrower SA-5 and furrower SA-3 in a 57,9%. From the energetic point of view T1 gained better energetic efficiency than treatment T2 in a 43,5% and treatment T3 in a 57,1%.

Get-it [ [Material gráfico]: sweet and juicy : E. Pons Valencia-España : R.E. 8344.

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