The European Court of Justice blocks the EU’s accession to the ECHR. CEPS Commentary, 8 January 2015

The goal of accession to the European Convention of Human Rights (ECHR) is to place the EU under the external oversight of the specialised court in Strasbourg. But in its Opinion of 18 December 2014 the Luxembourg-based European Court of Justice ruled that the draft accession agreement is not compatible with the EU treaties. In this commentary the authors argue that this would force EU member states to renegotiate the terms of accession to the ECHR. But meeting the demands made by the Court of Justice will prove to be very difficult.

The proteasome inhibitor MLN-273 blocks exoerythrocytic and erythrocytic development of Plasmodium parasites.

Protein degradation is regulated during the cell cycle of all eukaryotic cells and is mediated by the ubiquitin-proteasome pathway. Potent and specific peptide-derived inhibitors of the 20S proteasome have been developed recently as anti-cancer agents, based on their ability to induce apoptosis in rapidly dividing cells. Here, we tested a novel small molecule dipeptidyl boronic acid proteasome inhibitor, named MLN-273 on blood and liver stages of Plasmodium species, both of which undergo active replication, probably requiring extensive proteasome activity. The inhibitor blocked Plasmodium falciparum erythrocytic development at an early ring stage as well as P. berghei exoerythrocytic progression to schizonts. Importantly, neither uninfected erythrocytes nor hepatocytes were affected by the drug. MLN-273 caused an overall reduction in protein degradation in P. falciparum, as demonstrated by immunoblots using anti-ubiquitin antibodies to label ubiquitin-tagged protein conjugates. This led us to conclude that the target of the drug was the parasite proteasome. The fact that proteasome inhibitors are presently used as anti-cancer drugs in humans forms a solid basis for further development and makes them potentially attractive drugs also for malaria chemotherapy.

Practical concrete-block making; a simple practical treatise for the workman explaining the selection of the materials and the making of substantial concrete blocks and cement brick, together with directions for making molds and remarks on how to obtain the best architectural effects,

Mode of access: Internet.

The manufacture of concrete blocks and their use in building construction /

Includes index.

A PLATO lesson to teach begin blocks.

Thesis (M.S.)--University of Illinois at Urbana-Champaign.

Tree height reduction for parallel processing of blocks of Fortran assignment statements.

Thesis (M.S.)--University of Illinois.

New York daguerreotyped : group first, business-streets, mercantile blocks, stores, and banks.

Illustrated with engravings from daguerreotypes.

Photo-engraving; a practical treatise on the production of printing blocks by modern photograhic methods.

Mode of access: Internet.

Square blocks, and other sermons and articles,

Mode of access: Internet.

Specifications for treating and laying creosoted pine paving blocks /

Mode of access: Internet.

Concrete blocks.

Mode of access: Internet.

... Arithmetic on the productive system; accompanied by a key and cubical blocks.

At head of title: Smith's new arithmetic.

Arithmetic on the productive system : accompanied by a key and cubical blocks /

At head of title: Smith's new arithmetic.

Help to Zion's travellers : being an attempt to remove various stumbling blocks out of the way, relating to doctrinal, experimental, and practical religion /

Includes index.