The effect of body mass index on therapeutic response to bacterial vaginosis in pregnancy.

Our objective was to determine the effect of body mass index (BMI) on response to bacterial vaginosis (BV) treatment. A secondary analysis was conducted of two multicenter trials of therapy for BV and TRICHOMONAS VAGINALIS. Gravida were screened for BV between 8 and 22 weeks and randomized between 16 and 23 weeks to metronidazole or placebo. Of 1497 gravida with asymptomatic BV and preconceptional BMI, 738 were randomized to metronidazole; BMI was divided into categories: < 25, 25 to 29.9, and > or = 30. Rates of BV persistence at follow-up were compared using the Mantel-Haenszel chi square. Multiple logistic regression was used to evaluate the effect of BMI on BV persistence at follow-up, adjusting for potential confounders. No association was identified between BMI and BV rate at follow-up ( P = 0.21). BMI was associated with maternal age, smoking, marital status, and black race. Compared with women with BMI of < 25, adjusted odds ratio (OR) of BV at follow-up were BMI 25 to 29.9: OR, 0.66, 95% CI 0.43 to 1.02; BMI > or = 30: OR, 0.83, 95% CI 0.54 to 1.26. We concluded that the persistence of BV after treatment was not related to BMI.

The effect of body mass index on therapeutic response to bacterial vaginosis in pregnancy.

Our objective was to determine the effect of body mass index (BMI) on response to bacterial vaginosis (BV) treatment. A secondary analysis was conducted of two multicenter trials of therapy for BV and TRICHOMONAS VAGINALIS. Gravida were screened for BV between 8 and 22 weeks and randomized between 16 and 23 weeks to metronidazole or placebo. Of 1497 gravida with asymptomatic BV and preconceptional BMI, 738 were randomized to metronidazole; BMI was divided into categories: < 25, 25 to 29.9, and > or = 30. Rates of BV persistence at follow-up were compared using the Mantel-Haenszel chi square. Multiple logistic regression was used to evaluate the effect of BMI on BV persistence at follow-up, adjusting for potential confounders. No association was identified between BMI and BV rate at follow-up ( P = 0.21). BMI was associated with maternal age, smoking, marital status, and black race. Compared with women with BMI of < 25, adjusted odds ratio (OR) of BV at follow-up were BMI 25 to 29.9: OR, 0.66, 95% CI 0.43 to 1.02; BMI > or = 30: OR, 0.83, 95% CI 0.54 to 1.26. We concluded that the persistence of BV after treatment was not related to BMI.

Joan. Andr. Danzii Medaḳdeḳ sive Compendium grammaticae Hebraeae

opera et studio Joan. Henrici Zopfii

Sēfer Śimḥat han-nefeš : hier findeṭ jeder ṭrosṭ ... divre musar ...

[Elchanan Haendel Kirchhahn]. Naie bearbeiṭung und miṭ hosafos yeqoros benannṭ Meśibbat han-nefeš ... mimmenî Yehûdā kōhēn Qrôys

Maʿanē lāšôn oif ṭaiṭš : woś mn zol zogn oif di elṭrn un fraindś kevurim oich erev rosš ha-šone un erev jom kiper ...

Digitalisat der Ausg. Zultzbach, [1787/88]

An das deutsche Volk und seine Reichsversammlung: Wenn der Geist des ew'gen Lichtes winkt, da bricht auf ros'ger Bahn, Wie die Sonne durch's Gewölke, schön der Freiheit Morgen an ...

Welsch (Projektbearbeiter): Feierliches Gedicht zu Ehren der Frankfurter Nationalversammlung. Bekenntnis zu Freiheit und Einheit sowie zur allgemeinen Wehrpflicht

Impact of reactive oxygen species (ROS) on the control of parasite loads and inflammation in Leishmania amazonensis infection

Background: Reactive oxygen species (ROS) protect the host against a large number of pathogenic microorganisms. ROS have different effects on parasites of the genus Leishmania: some parasites are susceptible to their action, while others seem to be resistant. The role of ROS in L. amazonensis infection in vivo has not been addressed to date. Methods: In this study, C57BL/6 wild-type mice (WT) and mice genetically deficient in ROS production by phagocytes (gp91phox−/− ) were infected with metacyclic promastigotes of L. amazonensis to address the effect of ROS in parasite control. Inflammatory cytokines, parasite loads and myeloperoxidase (MPO) activity were evaluated. In parallel, in vitro infection of peritoneal macrophages was assessed to determine parasite killing, cytokine, NO and ROS production. Results: In vitro results show induction of ROS production by infected peritoneal macrophages, but no effect in parasite killing. Also, ROS do not seem to be important to parasite killing in vivo, but they control lesion sizes at early stages of infection. IFN-γ, TNF-α and IL-10 production did not differ among mouse strains. Myeloperoxidase assay showed augmented neutrophils influx 6 h and 72 h post - infection in gp91phox−/− mice, indicating a larger inflammatory response in gp91phox−/− even at early time points. At later time points, neutrophil numbers in lesions correlated with lesion size: larger lesions in gp91phox−/− at earlier times of infection corresponded to larger neutrophil infiltrates, while larger lesions in WT mice at the later points of infection also displayed larger numbers of neutrophils. Conclusion: ROS do not seem to be important in L. amazonensis killing, but they regulate the inflammatory response probably by controlling neutrophils numbers in lesions.

Geschichte der Vereinigten Staaten von Nord-Amerika, vom Jahre 1497 - 1837

aus dem Engl. übers. und hrsg. von Wilh. L. J. Kiderlen

Aus einer illustrierten Handschrift des Mahzor für Ros-ha-sanah, aschkenasischer Ritus [Illustration] : Vom gleichen Schreiber und Miniator wie bei der vorhergehenden Abbildung

Scan von Monochrom-Mikroform

Ausst. 326 - Directorium Moguntinum für die Zeit von Mariae Geburt [8.IX.] 1485 [oder 1496 ?] bis Mai 1486 [oder 1497 ?]

Vorbesitzer: Stadtarchiv Frankfurt am Main