Fine-scale estimations of bioclimatic change in the Valencia region, Spain

Recent advances in statistical downscaling have allowed the reconstruction of temperatures for the complete 1948–2011 period in a spatial resolution of 90 m and without gaps for the Valencian Community (Spain) and bordering areas. It presently enables analyses in this region, which allows the determination of recent temperature changes at subregional and local scales. The present work focuses on obtaining the thermicity index according to Rivas-Martínez, a well-known indicator of different thermotypes associated with bioclimatic horizons. The change in this index, which has happened in the region between 1948 and 2011, was calculated by generating fine-scale maps of the potential extension of different thermotypes. The results show a greater regression for the thermotypes in a finicolous position, e.g. Orotemperate, Supratemperate and Supramediterranean horizons, which herein indicate greater potential vulnerability in climate change. In the absence of, and given the need for, such fine-scale information, this work should be useful for specialized researchers to spatially limit the potentially most vulnerable biotopes to climate change.

La investigación en Bibliometría en la Argentina : Quiénes son y qué producen los autores argentinos que realizan estudios bibliométricos

Trabajo que tiene por objetivo observar y describir el panorama de la investigación bibliométrica en la Argentina en el período comprendido entre los años 1984 y 2012, a partir del análisis de las publicaciones de autores de instituciones argentinas localizadas en buscadores web, repositorios temáticos y bases de datos regionales e internacionales. Interpreta las formas que revisten los ítems estudiados enfocando la atención en el volumen y evolución de la producción, tipo de literatura, idioma, temas y unidades de análisis. Calcula el índice de coautoría y tasas de colaboración nacional e internacional. Identifica los autores más productivos y las instituciones de afiliación más frecuentes. Determina la existencia de algunos grupos de investigación, caracterizando sus temáticas de investigación, las revistas donde publican y los congresos más frecuentes en los que participan

La investigación en Bibliometría en la Argentina : Quiénes son y qué producen los autores argentinos que realizan estudios bibliométricos

Trabajo que tiene por objetivo observar y describir el panorama de la investigación bibliométrica en la Argentina en el período comprendido entre los años 1984 y 2012, a partir del análisis de las publicaciones de autores de instituciones argentinas localizadas en buscadores web, repositorios temáticos y bases de datos regionales e internacionales. Interpreta las formas que revisten los ítems estudiados enfocando la atención en el volumen y evolución de la producción, tipo de literatura, idioma, temas y unidades de análisis. Calcula el índice de coautoría y tasas de colaboración nacional e internacional. Identifica los autores más productivos y las instituciones de afiliación más frecuentes. Determina la existencia de algunos grupos de investigación, caracterizando sus temáticas de investigación, las revistas donde publican y los congresos más frecuentes en los que participan

Large scale experiments on gravel and mixed beaches: Experimental procedure, data documentation and initial results

This paper provides information on the experimental set-up, data collection methods and results to date for the project Large scale modelling of coarse grained beaches, undertaken at the Large Wave Channel (GWK) of FZK in Hannover by an international group of researchers in Spring 2002. The main objective of the experiments was to provide full scale measurements of cross-shore processes on gravel and mixed beaches for the verification and further development of cross-shore numerical models of gravel and mixed sediment beaches. Identical random and regular wave tests were undertaken for a gravel beach and a mixed sand/gravel beach set up in the flume. Measurements included profile development, water surface elevation along the flume, internal pressures in the swash zone, piezometric head levels within the beach, run-up, flow velocities in the surf-zone and sediment size distributions. The purpose of the paper is to present to the scientific community the experimental procedure, a summary of the data collected, some initial results, as well as a brief outline of the on-going research being carried out with the data by different research groups. The experimental data is available to all the scientific community following submission of a statement of objectives, specification of data requirements and an agreement to abide with the GWK and EU protocols. (C) 2005 Elsevier B.V. All rights reserved.

Comparative gene expression in brain regions of human alcoholics

The mesocorticolimbic system is the reward centre of the brain and the major target for drugs of abuse including alcohol. Neuroadaptive changes in this region are thought to underlie the process of tolerance and dependence. Recently, several research groups have searched for alcohol-responsive genes using high-throughput microarrays and well-characterized human post-mortem material. Comparison of data from these studies of cortical regions highlights the differences in experimental approach and selection of cases. However, alcohol-responsive gene sets associated with transcription, oxidative stress and energy production were common to these studies. In marked contrast, alcohol-responsive genes in the nucleus accumbens and the ventral tegmental area are primarily associated with changes in neurotransmission and signal transduction. These data support the concept that, within cortical regions, changes in gene expression are associated with alcoholism-related pathology. In the dopaminergic tract of the mesocorticolimbic system, alcohol-responsive gene sets suggest long-term neuroplastic changes in synaptic transmission.

Contribuições da COMSAÚDE na construção do conhecimento em Comunicação para a Saúde: resgate histórico e tendências dessa linha de pesquisa

O trabalho busca resgatar historicamente o surgimento e desenvolvimento da linha de pesquisa da Comunicação para a Saúde e fazer o mapeamento dos estudos dessa área nos Estados Unidos, América Latina e Brasil. Procura-se apresentar os principais grupos de pesquisa no Brasil em ambos os espaços Comunicação e Saúde e analisar as contribuições as sete edições da Conferência Brasileira de Comunicação para a Saúde (COMSAÚDE) para a consolidação da linha de pesquisa no Brasil, fazendo uma análise comparativa entre os trabalhos apresentados, autores e obras, com o que está sendo produzido em forma de teses e dissertações em outras universidades brasileiras, bem como na literatura americana. Utilizou-se o estudo exploratório, documental e análise de conteúdo para a realização do trabalho que apontou a difusão de inovações como raiz da linha de pesquisa em Comunicação para a Saúde.

Contribuições da COMSAÚDE na construção do conhecimento em Comunicação para a Saúde: resgate histórico e tendências dessa linha de pesquisa

O trabalho busca resgatar historicamente o surgimento e desenvolvimento da linha de pesquisa da Comunicação para a Saúde e fazer o mapeamento dos estudos dessa área nos Estados Unidos, América Latina e Brasil. Procura-se apresentar os principais grupos de pesquisa no Brasil em ambos os espaços Comunicação e Saúde e analisar as contribuições das sete edições da Conferência Brasileira de Comunicação para a Saúde (COMSAÚDE) para a consolidação da linha de pesquisa no Brasil, fazendo uma análise comparativa entre os trabalhos apresentados, autores e obras, com o que está sendo produzido em forma de teses e dissertações em outras universidades brasileiras, bem como na literatura americana. Utilizouse o estudo exploratório, documental e análise de conteúdo para a realização do trabalho que apontou a difusão de inovações como raiz da linha de pesquisa em Comunicação para a Saúde.

Molecular modelling assisted design and synthesis of cyclothialidine derivatives as DNA gyrase inhibitors

Since cyclothialidine was discovered as the most active DNA gyrase inhibitor in 1994, enormous efforts have been devoted to make it into a commercial medicine by a number of pharmaceutical companies and research groups worldwide. However, no serious breakthrough has been made up to now. An essential problem involved with cyclothialidine is that though it demonstrated the potent inhibition of DNA gyrase, it showed little activity against bacteria. This probably is attributable to its inability to penetrate bacterial cell walls and membranes. We applied the TSAR programme to generate a QSAR equation to the gram-negative organisms. In that equation, LogP is profoundly indicated as the key factor influencing the cyclothialidine activity against bacteria. However, the synthesized new analogues have failed to prove that. In the structure based drug design stage, we designed a group of open chain cyclothialidine derivatives by applying the SPROUT programme and completed the syntheses. Improved activity is found in a few analogues and a 3D pharmacophore of the DNA gyrase B is proposed to lead to synthesis of the new derivatives for development of potent antibiotics.

Ultra-long mode-locked Er-droped fibre lasers

The development of ultra-long (UL) cavity (hundreds of meters to several kilometres) mode-locked fibre lasers for the generation of high-energy light pulses with relatively low (sub-megahertz) repetition rates has emerged as a new rapidly advancing area of laser physics. The first demonstration of high pulse energy laser of this type was followed by a number of publications from many research groups on long-cavity Ytterbium and Erbium lasers featuring a variety of configurations with rather different mode-locked operations. The substantial interest to this new approach is stimulated both by non-trivial underlying physics and by the potential of high pulse energy laser sources with unique parameters for a range of applications in industry, bio-medicine, metrology and telecommunications. It is well known, that pulse generation regimes in mode-locked fibre lasers are determined by the intra-cavity balance between the effects of dispersion and non-linearity, and the processes of energy attenuation and amplification. The highest per-pulse energy has been achieved in normal-dispersion UL fibre lasers mode-locked through nonlinear polarization evolution (NPE) for self-modelocking operation. In such lasers are generated the so-called dissipative optical solitons. The uncompensated net normal dispersion in long-cavity resonatorsusually leads to very high chirp and, consequently, to a relatively long duration of generated pulses. This thesis presents the results of research Er-doped ultra-long (more than 1 km cavity length) fibre lasers mode-locked based on NPE. The self-mode-locked erbium-based 3.5-km-long all-fiber laser with the 1.7 µJ pulse energy at a wavelength of 1.55 µm was developed as a part of this research. It has resulted in direct generation of short laser pulses with an ultralow repetition rate of 35.1 kHz. The laser cavity has net normal-dispersion and has been fabricated from commercially-available telecom fibers and optical-fiber elements. Its unconventional linear-ring design with compensation for polarization instability ensures high reliability of the self-mode-locking operation, despite the use of a non polarization-maintaining fibers. The single pulse generation regime in all-fibre erbium mode-locking laser based on NPE with a record cavity length of 25 km was demonstrated. Modelocked lasers with such a long cavity have never been studied before. Our result shows a feasibility of stable mode-locked operation even for an ultra-long cavity length. A new design of fibre laser cavity – “y-configuration”, that offers a range of new functionalities for optimization and stabilization of mode-locked lasing regimes was proposed. This novel cavity configuration has been successfully implemented into a long-cavity normal-dispersion self-mode-locked Er-fibre laser. In particular, it features compensation for polarization instability, suppression of ASE, reduction of pulse duration, prevention of in-cavity wave breaking, and stabilization of the lasing wavelength. This laser along with a specially designed double-pass EDFA have allowed us to demonstrate anenvironmentally stable all-fibre laser system able to deliver sub-nanosecond high-energy pulses with low level of ASE noise.

Retinal vessel analysis:flicker reproducibility, methodological standardisations and practical limitations

The Retinal Vessel Analyser (RVA) is a commercially available ophthalmoscopic instrument capable of acquiring vessel diameter fluctuations in real time and in high temporal resolution. Visual stimulation by means of flickering light is a unique exploration tool of neurovascular coupling in the human retina. Vessel reactivity as mediated by local vascular endothelial vasodilators and vasoconstrictors can be assessed non-invasively, in vivo. In brief, the work in this thesis • deals with interobserver and intraobserver reproducibility of the flicker responses in healthy volunteers • explains the superiority of individually analysed reactivity parameters over vendorgenerated output • links in static retinal measures with dynamic ones • highlights practical limitations in the use of the RVA that may undermine its clinical usefulness • provides recommendations for standardising measurements in terms of vessel location and vessel segment length and • presents three case reports of essential hypertensives in a -year follow-up. Strict standardisation of measurement procedures is a necessity when utilising the RVA system. Agreement between research groups on implemented protocols needs to be met, before it could be considered a clinically useful tool in detecting or predicting microvascular dysfunction.

Optical spectral broadening and supercontinuum generation in telecom applications

We overview the recent development in applications of spectral broadening and supercontinuum generation in the field of optical communications. Special attention is dedicated to recent results obtained in our research groups. © 2005 Elsevier Inc. All rights reserved.

Changes at the BCLA

As we welcome 2014 we say goodbye to 2013 and I must start with an apology to authors who have submitted papers to CLAE and seen a delay in either the review process or the hard copy publication of their proofed article. The delays were caused by a major hike in the number of submissions to the journal in 2012 that increased further in 2013. In the 12 months leading to the end of October 2011 we had 94 new paper submissions, and for the same period to the end of 2012 the journal had 116 new papers. In 2012 we were awarded an impact factor for the first time and following that the next 12 month period to the end of October 2013 saw a massive increase in submissions with 171 new manuscripts being submitted. This is nearly twice as many papers as 2 years ago and 3 times as many as when I took over as Editor-in-Chief. In addition to this the UK academics will know that 2014 is a REF year (Research Excellence Framework) where universities are judged on their research and one of the major components of this measure remains to be published papers so there is a push to publishing before the REF deadline for counting. The rejection rate at CLAE has gone up too and currently is around 50% (more than double the rejection rate when I took over as Editor-in-Chief). At CLAE the number of pages that we publish each year has remained the same since 2007. When compiling issue 1 for 2014 I chose the papers to be included from the papers that were proofed and ready to go and there were around 200 proofed pages ready, which is enough to fill 3½ issues! At present Elsevier and the BCLA are preparing to increase the number the pages published per issue so that we can clear some of this backlog and remain up to date with the papers published in CLAE. I should add that on line publishing of papers is still available and there may have been review delays but there are no publishing online so authors can still get an epub on line final version of their paper with a DOI (digital object identifier) number enabling the paper to be cited. There are two awards that were made in 2013 that I would like to make special mention of. One was for my good friend Jan Bergmanson, who was awarded an honorary life fellowship of the College of Optometrists. Jan has served on the editorial board of CLAE for many years and in 2013 also celebrated 30 years of his annual ‘Texan Corneal and contact lens meeting’. The other award I wish to mention is Judith Morris, who was the BCLA Gold Medal Award winner in 2013. Judith has had many roles in her career and worked at Moorfields Eye Hospital, the Institute of Optometry and currently at City University. She has been the Europe Middle East and Africa President of IACLE (International Association of Contact Lens Educators) for many years and I think I am correct in saying that Judith is the only person who was President of both the BCLA (1983) and a few years later she was the President College of Optometrists (1989). Judith was also instrumental in introducing Vivien Freeman to the BCLA as they had been friends and Judith suggested that Vivien apply for an administrative job at the BCLA. Fast forward 29 years and in December 2013 Vivien stepped down as Secretary General of the BCLA. I would like to offer my own personal thanks to Vivien for her support of CLAE and of me over the years. The BCLA will not be the same and I wish you well in your future plans. But 2014 brings in a new position to the BCLA – Cheryl Donnelly has been given the new role of Chief Executive Officer. Cheryl was President of the BCLA in 2000 and has previously served on council. I look forward to working with Cheryl and envisage a bright future for the BCLA and CLAE. In this issue we have some great papers including some from authors who have not published with CLAE before. There is a nice paper on contact lens compliance in Nepal which brings home some familiar messages from an emerging market. A paper on how corneal curvature is affected by the use of hydrogel lenses is useful when advising patients how long they should leave their contact lenses out for to avoid seeing changes in refraction or curvature. This is useful information when refracting these patients or pre-laser surgery. There is a useful paper offering tips on fitting bitoric gas permeable lenses post corneal graft and a paper detailing surgery to implant piggyback multifocal intraocular lenses. One fact that I noted from the selection of papers in the current issue is where they were from. In this issue none of the corresponding authors are from the United Kingdom. There are two papers each from the United States, Spain and Iran, and one each from the Netherlands, Ireland, Republic of Korea, Australia and Hong Kong. This is an obvious reflection of the widening interest in CLAE and the BCLA and indicates the new research groups emerging in the field.

On Logical Correction of Neural Network Algorithms for Pattern Recognition

The paper is devoted to the description of hybrid pattern recognition method developed by research groups from Russia, Armenia and Spain. The method is based upon logical correction over the set of conventional neural networks. Output matrices of neural networks are processed according to the potentiality principle which allows increasing of recognition reliability.

PREFACE

The Conference on Partial Differential Equations and Applications, Sofia, September 14–16, 2011 (In honor of 65-th Anniversary of Professor Petar Popivanov) took place in the premises of the Institute of Mathematics and Informatics (IMI) of the Bulgarian Academy of Sciences (BAS). The conference was organized by the Section “Differential Equations and Mathematical Physics” of IMI with the participation of research groups on PDE from Universit`a di Cagliari and Universit`a di Torino (Italy), with the organizing committee – N. Kutev (IMI–BAS) – chair, G. Boyadzhiev (IMI–BAS) – secretary, T. Gramchev (Univ. Cagliari) and A. Oliaro (Univ. Torino) – members, and thefollowing program/scientific committee: T. Gramchev (chair), N. Kutev (IMI–BAS), L. Rodino (Universit`a di Torino), M. Ruzhansky (Imperial College London), A. Slavova (IMI–BAS), C. Van Der Mee (Universit`a di Cagliari).

Mode-locked semiconductor disk lasers

This paper will review the recent advances in the field of ultrashort pulse generation from optically pumped vertical-external-cavity surface-emitting lasers (OP-VECSELs). In this review, we will summarize the most significant results presented over the last 15 years, before highlighting recent breakthroughs related to mode-locked VECSELs by different research groups. Different mode-locking techniques for OP-VECSELs are described in detail. Previously, saturable absorbers, such as semiconductor saturable absorber mirrors—external, or internal as in mode-locked integrated external-cavity surface emitting lasers (MIXSEL)—, and recently, novel-material-based carbon-nanotube and graphene saturable absorbers have been employed. A new mode-locking method was presented and discussed in recent years. This method is referred to as self-mode-locking or saturable-absorber-free operation of mode-locked VECSELs. In this context, we particularly focus on achievements regarding self-mode-locking, which is considered a promising technique for the realization of high-power, compact, robust and cost-efficient ultrashort pulse lasers. To date, the presented mode-locking techniques have led to great enhancement in average powers, peak powers, and repetition rates that can be achieved with passively mode-locked VECSELs.