Exposición y exámen crítico de las diversas teorías generales sobre la composición racional de los cuerpos orgánicos : discurso leído en la Universidad Central /

Tesis de la Universidad Central (Madrid), Facultad de Farmacia, leída el 21-05-1864.

[Análisis inmediata de las sustancias orgánicas] : discursos leídos ante el Claustro de la Universidad de Granada en el acto solemne de la recepción del catedrático numerario... el día 15 de diciembre de 1861 ; [Contestación al discurso anterior ; por Mariano del Amo] /

Mode of access: Internet.

Considérations générales sur l'analyse organique et sur ses applications /

Mode of access: Internet.

Traité de chimie organique /

Mode of access: Internet.

Traité de chimie organique /

Contiene: v. 1 - v. 2 - v. 3.

Traité de chimie générale, analytique, industrielle et agricole. analyse, acides, alcaloïdes, coprs neutres /

Mode of access: Internet.

Abrégé de chimie /

Mode of access: Internet.

Nouveau système de chimie organique fondé sur des nouvelles méthodes d'observation : et précédé d'un traité complet de l'art d'observer etde manipuler en grand et en petiti dans le laboratoire et sur le porte-objet du microscope /

Índice.

Éléments de chimie inorganique et organique /

Mode of access: Internet.

[Acción del calórico sobre las sustancias químico-orgánicas de aplicación a la Farmacia] : Discurso leido ante el Claustro de la Universidad Central en el acto solemne de recibir la investidura de doctor en la Facultad de Farmacia /

Tesis de la Universidad Central (Madrid), Facultad de Farmacia, leída el 16-01-1865.

Traité de chimie générale, analytique, industrielle et agricole.

Mode of access: Internet.

Traité de chimie générale, analytique, industrielle et agricole.

Mode of access: Internet.

Proposta de jogo químico como estratégia didática no ensino a distância abordando o conteúdo de estereoquímica

The educational games can act as a complementary tool in the teaching and learning as play an important role in the interaction of the student with knowledge, and encourage interrelationship between students and motivate them by the pursuit of knowledge. This research is intended to analyze the evidence of the students of distance education applied to semesters 2011.2 and 2012.2 for the purpose of to catalog the mistakes presented by the students, the contents of stereochemistry that attended the Chemistry of Life discipline. From the presented mistekes, develop an educational game, "walking the stereochemistry", addressing that content. The choice of stereochemistry content was due to the low number of found work in the literature, and for being one of organic chemistry content that generates learning difficulties, as it requires a mental visualization and manipulation of molecular structures, besides require observation and comparison ability by the students. The game was applied of Life Chemistry discipline of Nova Cruz Polo in semester 2013.2, with intention to verify the viability and applicability this tool for the development of motivation ability by the pursuit of knowledge by the students, as well as complement the didactical materials of the DE. Then, It was made available on the course page an opinion questionnaire to the participants of the game, as a way of to investigate the opinion their about the proposed strategy. To diagnose the contributions of the game on student learning, it was taken a comparative analysis of stereochemistry issues contained in didactic tests applied in 2013.2 semester students participating and not participating of the polo of Nova Cruz and was also compared with the tests applied at the poles of Extremoz, Currais Novos, Lajes and Caico. So the game can be considered an important resource to complement the teaching materials of distance education, because awoke the motivation for the search of knowledge and contributes to the learning of stereochemistry content.

Novos protocolos teóricos utilizados nos estudos das ligações hidrogênio-hidrogênio, na estabilidade do tetraedrano, seus derivados e das reações de diels-alder e na quantificação da afinidade de fármacos

This thesis was performed in four chapters, at the theoretical level, focused mainly on electronic density. In the first chapter, we have applied an undergraduate minicourse of Diels-Alder reaction in Federal University of Rio Grande do Norte. By using computational chemistry tools students could build the knowledge by themselves and they could associate important aspects of physical-chemistry with Organic Chemistry. In the second chapter, we studied a new type of chemical bond between a pair of identical or similar hydrogen atoms that are close to electrical neutrality, known as hydrogen-hydrogen (H-H) bond. In this study performed with complexed alkanes, provides new and important information about their stability involving this type of interaction. We show that the H-H bond playing a secondary role in the stability of branched alkanes in comparison with linear or less branched isomers. In the third chapter, we study the electronic structure and the stability of tetrahedrane, substituted tetrahedranes and silicon and germanium parents, it was evaluated the substituent effect on the carbon cage in the tetrahedrane derivatives and the results indicate that stronger electron withdrawing groups (EWG) makes the tetrahedrane cage slightly unstable while slight EWG causes a greater instability in the tetrahedrane cage. We showed that the sigma aromaticity EWG and electron donating groups (EDG) results in decrease and increase, respectively, of NICS and D3BIA aromaticity indices. In addition, another factor can be utilized to explain the stability of tetra-tert-butyltetrahedrane as well as HH bond. GVB and ADMP were also used to explain the stability effect of the substituents bonded to the carbon of the tetrahedrane cage. In the fourth chapter, we performed a theoretical investigation of the inhibitory effect of the drug abiraterone (ABE), used in the prostate cancer treatment as CYP17 inhibitor, comparing the interaction energies and electron density of the ABE with the natural substrate, pregnenolone (PREG). Molecular dynamics and docking were used to obtain the CYP1ABE and CYP17-PREG complexes. From molecular dynamics was obtained that the ABE has higher diffusion trend water CYP17 binding site compared to the PREG. With the ONIOM (B3LYP:AMBER) method, we find that the interaction electronic energy of ABE is 21.38 kcal mol-1 more stable than PREG. The results obtained by QTAIM indicate that such stability is due a higher electronic density of interactions between ABE and CYP17

Extraction system and determination of PAH in seawater and it implementation in submarine vehicles

[EN]Policyclyc aromatic hydrocarbons (PAHs) are a potential risk for human health and marine biota in general that make necessary the monitorization of them. A miniaturized extraction system capable to extract PAHs from seawater was developed and optimized with the objective of implement it in an oceanographic buoy in the future. An analytical method was optimized by high performance liquid chromatography for the determination of extracted PAHs by the extraction system. The analytical method was validated and applicated to real samples of differents points of Gran Canaria. The method has enough sensitivity to detect and quantify concentrations below the concentrations established in the legislation. In some places where samples were taken some compounds exceed the legislation while other compounds follow it