916 resultados para Ossorio y Bernard, Manuel, 1839-1904.


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Sign.: A2

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Proyecto de dinamo de corriente contínua

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Hay un ejemplar encuadernado con: Bandos divertidísimos contra los borrachos y borrachas, y gente aficionada al vino (NP849.91/3087)

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Hay un ejemplar encuadernado con: Bandos divertidísimos contra los borrachos y borrachas, y gente aficionada al vino (NP849.91/3087).

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We would like to thank the animal house staff and all members of the Energetics group for their invaluable help at various stages throughout the project. This work was supported by Natural Environment Research Council grant (NERC, NE/C004159/1). YG was supported by a scholarship from the rotary foundation. LV was supported by a Rubicon grant from the Netherlands Scientific Organisation (NWO).

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Patch–clamp recordings of CA1 interneurons and pyramidal cells were performed in hippocampal slices from kainate- or pilocarpine-treated rat models of temporal lobe epilepsy. We report that γ-aminobutyric acid (GABA)ergic inhibition in pyramidal neurons is still functional in temporal lobe epilepsy because: (i) the frequency of spontaneous GABAergic currents is similar to that of control and (ii) focal electrical stimulation of interneurons evokes a hyperpolarization that prevents the generation of action potentials. In paired recordings of interneurons and pyramidal cells, synchronous interictal activities were recorded. Furthermore, large network-driven GABAergic inhibitory postsynaptic currents were present in pyramidal cells during interictal discharges. The duration of these interictal discharges was increased by the GABA type A antagonist bicuculline. We conclude that GABAergic inhibition is still present and functional in these experimental models and that the principal defect of inhibition does not lie in a complete disconnection of GABAergic interneurons from their glutamatergic inputs.

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1. Hojas dispersas.--2. De ayer.--3. A través de un temperamento.--4. Juventud Bohemia.--5. Del fondo del alma.--6. En el proscenio y en la tribuna.

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Poems.