Akty, otnosi︠a︡shchīesi︠a︡ k istorīi i︠u︡zhnoĭ i zapadnoĭ Rossīi.

Mode of access: Internet.

Ezhemi͡esi͡achny ̆bi͡ulletenʹ po gorodu Moskvi͡e. Bulletin statistique mensuel de la ville de Moscou.

Summary at end of each year.

Gramoty i drugīe istoricheskīe dokumenty XVIII stoli͡etīi͡a, otnosi͡ashchīesi͡a k Gruzīi /

Documents in Russian and Georgian.

Materīaly istorīi drevneĭ Rossīi khrani͡a︡shchīesi͡a︡ v Kopengageni͡e︡: 1326-1690 gg.

Mode of access: Internet.

Akty, otnosi͡a︡shchīesi͡a︡ do i͡u︡ridicheskago byta drevneĭ Rossīi /

Each sheet entitled: Kalac̮ov, N. V. Akty, otnosjaščiesja do juridičeskago byta... (R-10,146). Moskva, 1857-

Pushkin : dokumenty Gosudarstvennago i S.-Peterburgskago glavnago arkhivov Ministerstva inostrannykh di͡e︡l, otnosi͡a︡shchīesi͡a︡ k sluzhbi͡e︡ ego 1831-1837 gg. S semʹi͡u︡ snimkami s avtografov Pushkina i odnim snimkom s podlinnago svidi͡e︡telʹstva ob okonchanīi im kursa v Imperatorskom t͡s︡arskoselʹskom lit͡s︡ei͡e︡ /

Includes bibliographical references.

Operator and organizational field maintenance manual : cable layer, underground LC-236/MT.

"6 March 1963."

Enhancing the ratio of molecular ions to non-covalent compounds in the electrospray interface of LC-MS in quantitative analysis

A common problem encountered during the development of MS methods for the quantitation of small organic molecules by LGMS is the formation of non-covalently bound species or adducts in the electrospray interface. Often the population of the molecular ion is insignificant compared to those of all other forms of the analyte produced in the electrospray, making it difficult to obtain the sensitivity required for accurate quantitation. We have investigated the effects of the following variables: orifice potential, nebulizer gas flow, temperature, solvent composition and the sample pH on the relative distributions of ions of the types MH+, MNa+, MNH+, and 2MNa(+), where M represents a 4 small organic molecule: BAY 11-7082 ((E)-3-[4-methylphenylsulfonyl]-2-propenenitrile). Orifice potential, solvent composition and the sample pH had the greatest influence on the relative distributions of these ions, making these parameters the most useful for optimizing methods for the quantitation of small molecules.

Matrix effects: The Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry

High-performance liquid chromatography coupled by an electrospray ion source to a tandem mass spectrometer (HPLC-EST-MS/ MS) is the current analytical method of choice for quantitation of analytes in biological matrices. With HPLC-ESI-MS/MS having the characteristics of high selectivity, sensitivity, and throughput, this technology is being increasingly used in the clinical laboratory. An important issue to be addressed in method development, validation, and routine use of HPLC-ESI-MS/MS is matrix effects. Matrix effects are the alteration of ionization efficiency by the presence of coeluting substances. These effects are unseen in the chromatograrn but have deleterious impact on methods accuracy and sensitivity. The two common ways to assess matrix effects are either by the postextraction addition method or the postcolumn infusion method. To remove or minimize matrix effects, modification to the sample extraction methodology and improved chromatographic separation must be performed. These two parameters are linked together and form the basis of developing a successful and robust quantitative HPLC-EST-MS/MS method. Due to the heterogenous nature of the population being studied, the variability of a method must be assessed in samples taken from a variety of subjects. In this paper, the major aspects of matrix effects are discussed with an approach to address matrix effects during method validation proposed. (c) 2004 The Canadian Society of Clinical Chemists. All rights reserved.

Taxonomy of Australian Funnel-web spiders using rp-HPLC/ESI-MS profiling techniques

The complex nature of venom from spider species offers a unique natural source of potential pharmacological tools and therapeutic leads. The increased interest in spider venom molecules requires reproducible and precise identification methods. The current taxonomy of the Australian Funnel-web spiders is incomplete, and therefore, accurate identification of these spiders is difficult. Here, we present a study of venom from numerous morphologically similar specimens of the Hadronyche infensa species group collected from a variety of geographic locations in southeast Queensland. Analysis of the crude venoms using online reversed-phase high performance liquid chromatography/electrospray ionisation mass spectrometry (rp-HPLC/ESI-MS) revealed that the venom profiles provide a useful means of specimen identification, from the species level to species variants. Tables defining the descriptor molecules for each group of specimens were constructed and provided a quick reference of the relationship between one specimen and another. The study revealed that the morphologically similar specimens from the southeast Queensland region are a number of different species/species variants. Furthermore, the study supports aspects of the current taxonomy with respect to the H. infensa species group. Analysis of Australian Funnel-web spider venom by rp-HPLC/ESI-MS provides a rapid and accurate method of species/species variant identification. (c) 2006 Elsevier Ltd. All rights reserved.