Smartphone and GPS technology for freeroaming dog population surveillance -a methodological study (Studio metodologico sull’applicazione di smartphone e tecnologia GPS alla sorveglianza delle popolazioni di cani vaganti)

Free-roaming dogs (FRD) represent a potential threat to the quality of life in cities from an ecological, social and public health point of view. One of the most urgent concerns is the role of uncontrolled dogs as reservoirs of infectious diseases transmittable to humans and, above all, rabies. An estimate of the FRD population size and characteristics in a given area is the first step for any relevant intervention programme. Direct count methods are still prominent because of their non-invasive approach, information technologies can support such methods facilitating data collection and allowing for a more efficient data handling. This paper presents a new framework for data collection using a topological algorithm implemented as ArcScript in ESRI® ArcGIS software, which allows for a random selection of the sampling areas. It also supplies a mobile phone application for Android® operating system devices which integrates Global Positioning System (GPS) and Google Maps™. The potential of such a framework was tested in 2 Italian regions. Coupling technological and innovative solutions associated with common counting methods facilitate data collection and transcription. It also paves the way to future applications, which could support dog population management systems.

Immune-derived PD-L1 gene expression defines a subgroup of stage II/III colorectal cancer patients with favorable prognosis that may be harmed by adjuvant chemotherapy

A recent phase 2 study of metastatic colorectal carcinoma (CRC) patients showed that mismatch repair gene status was predictive of clinical response to PD-1-targeting immune checkpoint blockade. Further examination revealed strong correlation between PD-L1 protein expression and microsatellite instability (MSI) in stage IV CRC, suggesting that the amount of PD-L1 protein expression could identify late stage patients who may benefit from immunotherapy. To assess whether the clinical associations between PD-L1 gene expression and MSI identified in metastatic CRC are also present in stage II/III CRC, we used in silico analysis to elucidate the cell types expressing the PD-L1 gene. We found a significant association of PD-L1 gene expression with MSI in early stage CRC (P < 0.001) and show that unlike in non-CRC tumors, PD-L1 is derived predominantly from the immune infiltrate. We demonstrate that PD-L1 gene expression has positive prognostic value in the adjuvant disease setting (PD-L1low v PD-L1high HR = 9.09; CI, 2.11-39.10). PD-L1 gene expression had predictive value, as patients with high PD-L1 expression appear to be harmed by standard-of-care treatment (HR = 4.95; CI,1.10-22.35). Building on the promising results from the metastatic CRC PD-1-targeting trial, we provide compelling evidence that PD-L1high/MSI/immunehigh stage II/III CRC patients should not receive standard chemotherapy. This conclusion supports the rationale to clinically evaluate this patient subgroup for PD-1 blockade treatment.

Study of the impact from nonlinear distortion in radio receiver architectures

A dissertação de doutoramento apresentada insere-se na área de electrónica não-linear de rádio-frequência (RF), UHF e microondas, tendo como principal campo de acção o estudo da distorção nãolinear em arquitecturas de recepção rádio, nomeadamente receptores de conversão directa como Power Meters, RFID (Radio Frequency IDentification) ou SDR (Software Define Radio) front-ends. Partindo de um estudo exaustivo das actuais arquitecturas de recepção de radiofrequência e revendo todos os conceitos teóricos relacionados com o desempenho não-linear dos sistemas/componentes electrónicos, foram desenvolvidos algoritmos matemáticos de modulação dos comportamentos não-lineares destas arquitecturas, simulados e testados em laboratório e propostas novas arquitecturas para a minimização ou cancelamento do impacto negativo de grandes interferidores em frequências vizinhas ao do sistema pretendido.

Monitorização de frotas urbanas com GPS

Com o objectivo de desenvolver um sistema de monitorização de frotas de transportes públicos urbanos, cujo posicionamento de veículos seja feito com precisão superior a 10 m, a Faculdade de Ciências da Universidade de Lisboa juntamente com o Instituto das Ciências da Terra e do Espaço iniciaram o desenvolvimento de um protótipo, denominado SIMOV (Sistema de Monitorização de Veículos), com base na frota da CARRIS de Lisboa, usando o GPS (Global Positioning System) como único sistema de posicionamento. O sistema em desenvolvimento é composto por três módulos: posicionamento, comunicação e monitorização. Deste estudo apenas serão apresentadas as soluções para o posicionamento e para a monitorização. Relativamente ao posicionamento a apresentação centrar-se-á no estudo desenvolvido com vista ao uso de apenas dois satélites da constelação GPS em curtos períodos de tempo, frequente em circuitos urbanos, já que o posicionamento com três ou mais satélites é um dado adquirido, resultando fiável em termos da precisão pretendida. Para a monitorização (visualização do posicionamento) serão projectadas duas soluções, usando dados GPS recolhidos na execução do percurso habitual da carreira 38 da CARRIS, a primeira sobre uma base de dados cartográfica de eixos de via da cidade com precisão aproximada do metro e a segunda sobre a representação do trajecto como uma linha recta.

IB-DFE receiver techniques for CP-assisted block transmission within DS-CDMA and MC-CDMA systems

MC-CDMA (MultiCarrier Code Division Multiple Access), currently regarded as a promissing multiple access scheme for broadband communications, is known to combine the advantages of an OFDM-based (Orthogonal Frequency Division Multiplexing), CP-assisted (Cyclic Prefix) block transmission with those of CDMA systems. Recently, it was recognised that DS-CDMA (Direct Sequence) implementations can also take advantage of the beneficts of the CP-assisted block transmission approach, therefore enabling an efficient use of FFT-based (Fast Fourier Transform), chip level FDE (Frequency- Domain Equalisation) techniques. In this paper we consider the use of IB-DFE (Iterative Block Decision Feedback Equalisation) FDE techniques within both CP-assisted MC-CDMA systems with frequency-domain spreading and DS-CDMA systems. Our simulation results show that an IB-DFE receiver with moderate complexity is suitable in both cases, with excellent performances that can be close to the single-code matched filter bound (especially for the CP-assisted DSCDMA alternative), even with full code usage.

Análise de estratégias de processamento de dados GPS

Nos últimos anos, a rede de estações GPS permanentes tem crescido de forma sustentada em todo o mundo. Também em Portugal existe um número cada vez maior de estações permanentes, a maior parte das quais ligadas a instituições públicas e universidades. O volume de dados produzido por estas redes implica a criação de procedimentos automáticos de processamento de observações com metodologias adequadas. Tendo como objectivo principal processar os dados GPS provenientes de uma rede de estações da Faculdade de Ciências da Universidade de Lisboa (FCUL), foi elaborado um sistema de processamento automático de observações para um conjunto alargado de estações. A rede é constituída por estações IGS (Madrid, Maspalomas, Ponta Delgada, San Fernando e Villa Franca del Campo), por estações EUREF (Cascais, Vila Nova de Gaia e Lagos) e estações da FCUL (Flores, Graciosa, Santa Maria, Instituto de Meteorologia da Madeira, Observatório Astronómico de Lisboa Norte, Observatório Astronómico de Lisboa Sul). O processamento de observações GPS foi feito com recurso ao Bernese Processing Engine, uma componente do Bernese GPS Software 4.2, e foram utilizadas diferentes estratégias que incluem a modificação do ângulo de máscara, a determinação de gradientes troposféricos e a inclusão do efeito de carga oceânica. Neste trabalho são analisadas várias séries temporais e discutidas as vantagens e desvantagens de cada uma das estratégias utilizadas.

A frequency-domain receiver for asynchronous systems employing CP-assisted DS-CDMA schemes

In this paper we consider the uplink transmission within CP-assisted (Cyclic Pre¯x) DS-CDMA (Direct Sequence Code Division Multiple Access) systems and we present a frequency-domain MUD (MultiUser Detection) receiver with iterative estimation and compensation of residual frequency errors. The proposed receiver is suitable for broadband wireless systems, with performances that can be close to the single-user MFB (Matched Filter Bound), even for fully loaded systems and/or in the presence of strong interfering signals. The receiver is powerful enough for typical asynchronous scenarios, requiring only a coarse synchronization between users.

Étude de la consistance interne du Guide pour s'orienter (GPS)

Le Guide pour s'orienter (GPS) est un récent questionnaire en ligne conçu pour aider les jeunes à explorer leurs ressources internes et celles provenant de leur environnement, qui peuvent influencer leur orientation. Cet instrument est basé sur le concept du Sentiment d'efficacité personnelle (SEP) de Bandura et sur diverses théories du développement de carrière. Le but de cet article est de décrire les propriétés psychométriques relatives à la fidélité du GPS, avec le calcul des indices de consistance interne des échelles. En général, les résultats démontrent que la plupart des échelles du GPS ont un niveau de fidélité acceptable, notamment celles concernant les ressources internes.

Adaptive self-calibrating image rejection receiver

An adaptive self-calibrating image rejection receiver is described, containing a modified Weaver image rejection mixer and a Digital Image Rejection Processor (DIRP). The blind source-separation-based DIRP eliminates the I/Q errors improving the Image Rejection Ratio (IRR) without the need for trimming or use of power-hungry discrete components. Hardware complexity is minimal, requiring only two complex coefficients; hence it can be easily integrated into the signal processing path of any receiver. Simulation results show that the proposed approach achieves 75-97 dB of IRR.

Performance of an adaptive homodyne receiver in the presence of multipath, Rayleigh-fading and time-varying quadrature errors

In this paper, we carry out a detailed performance analysis of the blind source separation based I/Q corrector operating at the baseband. Performance of the digital I/Q corrector is evaluated not only under time-varying phase and gain errors but also in the presence of multipath and Rayleigh fading channels. Performance under low-SNR and different modulation formats and constellation sizes is also evaluated. What is more, BER improvement after correction is illustrated. The results indicate that the adaptive algorithm offers adequate performance for most communication applications hence, reducing the matching requirements of the analog front-end enabling higher levels of integration.

Correction of transmitter gain and phase errors at the receiver

This paper explores the benefits of compensating transmitter gain and phase inbalances in the receiver for quadrature communication systems. It is assumed that the gain and phase imbalances are introduced at the transmitter only. A simple non-data aided DSP algorithm is used at the reciever to compensate for the imbalances. Computer simulation has been formed to study a coherent QPSK communication system.

A low-complexity self-calibrating adaptive quadrature receiver

In this paper digital part of a self-calibrating quadrature-receiver is described, containing a digital calibration-engine. The blind source-separation-based calibration-engine eliminates the RF-impairments in real-time hence improving the receiver's performance without the need for test/pilot tones, trimming or use of power-hungry discrete components. Furthermore, an efficient time-multiplexed calibration-engine architecture is proposed and implemented on an FPGA utilising a reduced-range multiplier structure. The use of reduced-range multipliers results in substantial reduction of area as well as power consumption without a compromise in performance when compared with an efficiently designed general purpose multiplier. The performance of the calibration-engine does not depend on the modulation format or the constellation size of the received signal; hence it can be easily integrated into the digital signal processing paths of any receiver.

Design and low-power implementation of an adaptive image rejection receiver

This paper deals with and details the design and implementation of a low-power; hardware-efficient adaptive self-calibrating image rejection receiver based on blind-source-separation that alleviates the RF analog front-end impairments. Hybrid strength-reduced and re-scheduled data-flow, low-power implementation of the adaptive self-calibration algorithm is developed and its efficiency is demonstrated through simulation case studies. A behavioral and structural model is developed in Matlab as well as a low-level architectural design in VHDL providing valuable test benches for the performance measures undertaken on the detailed algorithms and structures.

Design of a power-aware digital image rejection receiver

This paper deals with and details the design of a power-aware adaptive digital image rejection receiver based on blind-source-separation that alleviates the RF analog front-end impairments. Power-aware system design at the RTL level without having to redesign arithmetic circuits is used to reduce the power consumption in nomadic devices. Power-aware multipliers with configurable precision are used to trade-off the image-rejection-ratio (IRR) performance with power consumption. Results of the simulation case studies demonstrate that the IRR performance of the power-aware system is comparable to that of the normal implementation albeit degraded slightly, but well within the acceptable limits.