Reversão sexual de tilápias gift criadas em hapas e submetidas a diferentes taxas de alimentação em alta frequência

Pós-graduação em Zootecnia - FMVZ

Efeitos da adição de agentes tróficos na dieta de leitões desmamados sobre a expressão da enzima ornitina descarboxilase, os conteúdos de proteína e DNA e o desempenho

Two experiments were carried out to evaluate the effect of adding glutamine, fish oil or yeast cellular wall to the diet of weaned piglets on the expression of the enzyme ornithine decarboxylase (ODC), the protein content and DNA in small intestine samples and on performance. In the first experiment, 24 weaned piglets were used to measure the performance at the phases prestarter, starter 1 and starter 2. Four diets were tested (T1 -basal diet (BD); T2 -BD + 1% of glutamine; T3 -BD + 0,2% of yeast cellular wall; T4 -BD + 5% of fish oil). At the second experiment 45 weaned piglets were used and distributed in a randomized block design, in factorial outline with four diets and three slaughter ages (on the day of weaning, on the seventh and fourteenth days postweaning). The tested diets did not alter the piglets' performance in none of the phases. There was reduction of the expression of the ODC enzyme, of the protein concentration and of the relationship protein/DNA to the seven days postweaning, with increase of the values on the 14th day, evidencing a state of hypotrophy of the mucous membrane, suggesting that the process of protein synthesis in the small intestine was diminished in the first week after weaning, but it presented recovery signs in the second week.

Long-term low intensity physical exercise attenuates heart failure development in aging spontaneously hypertensive rats

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Comparative study between photodynamic and antibiotic therapies for treatment of footpad dermatitis (bumblefoot) in Magellanic penguins (Spheniscus magellanicus)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Improvement of the physical performance is associated with activation of NO/PGC-l alpha/mtTFA signaling pathway and increased protein expressions of electron transport chain in gastrocnemius muscle from rats supplemented with L-arginine

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efficacy of prebiotics, probiotics, and synbiotics on laying hens and broilers challenged with salmonella enteritidis

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

In vivo assessment of genotoxic, antigenotoxic and anticarcinogenic activities of Solanum lycocarpum fruits glycoalkaloidic extract

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The effect of non-antihypertensive doses of angiotensin converting enzyme inhibitor on myocardial necrosis and hypertrophy in young rats with renovascular hypertension

In renovascular hypertensive rats, low doses of angiotensin converting enzyme (ACE) inhibitors have been found to prevent myocardial hypertrophy independent of blood pressure level. This finding would suggest humoral rather than mechanical control of myocyte growth. The aim of this study was to examine the effect of nonantihypertensive doses of ACE inhibitor on myocardial hypertrophy and necrosis in hypertensive rats. Renovascular hypertension (RHT) was induced in four-week-old Wistar rats. Twenty-eight animals were treated for four weeks with three doses of ramipril (0.01, 0.1 or 1. 0 mg/kg/day, which are unable to lower blood pressure. Fourteen animals were not treated (RHT group). A sham operated, age/sex-matched group was used as control (n = 10). Myocardial histology was analysed in 3 microm thick sections of the ventricle stained with either haematoxylin-eosin, reticulin silver stain or Masson's trichrome. There was a significant correlation between systolic blood pressure and left ventricular to body weight ratio in both sets of animals: untreated plus controls and ramipril-treated rats. ACE inhibition prevented myocyte and perivascular necrosis and fibrosis in a dose-dependent manner. We conclude that myocardial hypertrophy in rats with renovascular hypertension is directly related to arterial pressure, and that this relationship is not affected by nonantihypertensive doses of ACE inhibitor. Myocardial necrosis/fibrosis and coronary artery damage induced by angiotensin II are prevented by ACE inhibitor in a dose-dependent manner, despite the presence of arterial hypertension.

Sodium nitrite prevents both reductions in circulating nitric oxide and hypertension in 7-day lead-treated rats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Gestational and lactational exposition to Di-N-butyl-phthalate (DBP) increases inflammation and preneoplastic lesions in prostate of wistar rats after carcinogenic N-methyl-N-nitrosourea (MNU) plus testosterone protocol

In the present study, it was evaluated the susceptibility of prostatic lesions in male adult rats exposed to Di-N-butyl-phthalate during fetal and lactational periods and submitted to MNU plus testosterone carcinogenesis protocol. Pregnant females were distributed into four experimental groups: CN (negative control); CMNU (MNU control); TDBP100 (100 mg/kg of DBP); TDBP500 (500 mg/kg of DBP). Females from the TDBP groups received DBP, by gavage, from gestation day 15 (GD15) to postnatal day 21 (DPN21), while C animals received the vehicle (corn oil). CMNU, TDBP100, and TDBP500 groups received a single intraperitoneal injection of MNU (50 mg/kg) on the sixth postnatal week. After that, testosterone cypionate was administered subcutaneously two times a week (2 mg/kg) for 24 weeks. The animals were euthanized on PND220. Distal segment fragments of the ventral (VP) and dorsolateral prostate (DLP) were fixed and processed for histopathological analysis. Protein extracts from ventral prostate were obtained, and western blotting was performed to AR, ERα, MAPK (ERK1/2), and pan-AKT. Stereological analysis showed an increase in the epithelial compartment in TDBP100 and TDBP500 compared to CN. In general, there was increase in the incidence of inflammation and metaplasia/dysplasia in the DBP-treated groups, mainly in DLP, compared to CN and CMNU. Proliferation index was significant higher in TDBP500 and PIN (prostatic intraepithelial neoplasia) was more frequent in this group compared to CMNU. Western blot assays showed an increase in the expressions of AR and MAPK (ERK1/2) in the TDBP100 compared to CN, and ERα and AKT expressions were higher in the TDBP500 group compared do CN. These results showed that different doses of DBP during prostate organogenesis in Wistar rats could increase the incidence of premalignant lesions in initiated rats inducing distinct biological responses in the adulthood. © 2015 Wiley Periodicals, Inc. Environ Toxicol, 2015.

Expression of estrus modifies the gene expression profile in reproductive tissues on Day 19 of gestation in beef cows

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Contribuição ao estudo das relações dos conectores maiores de próteses parciais removíveis com tecidos gengivais

The effect in the gingival tissue of four distinctive types of relationships between the major conector and the gingival margin was investigated in eight subjects in association with the experimental gingivitis model. The subjects wore appliances constructed in acrylic resin (retained by means of embrasure hooks) throughout the day an night, except during meals. After the appliances had been placed, the subjects were abstained from any oral hygiene for twenty-one days. Records of the Plaque Index, Gingival Index and probing deplh were taken at baseline and at each week. Data showed that there was a small increase in the Plaque Index and Gingival Index for the four areas and that the degree of inflammation of the covered areas was higher in the area without relief

O exercício físico é capaz de melhorar expressão de AMPK e GLUT4 em músculo esquelético de ratos alcoolistas e/ou tabagistas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The response of the lactate minimum test to a 12-week swimming training

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Modelos para estimar consumo e exigências nutricionais para poedeiras comerciais

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)