Fortifications.

War dept. doc. no. 513.

Notas sôbre alguns engenheiros nas praças de Africa; para servir de aditamental dos architectos, engenheiros e constructores portuguezes ou ao serviço de Portugal,

Mode of access: Internet.

Guerra de los Estados-Unidos.

Mode of access: Internet.

Essai sur l'architecture militaire au Môyen âge.

Mode of access: Internet.

Probestücke von Städtemauern des alten Griechenlands /

"Aus dem Englischen übersetzt."

The report of the Commissioners Sent into Spain : pursuant to an address of the House of Commons to Her late Majesty Queen Anne, relating to Gibralter and some other places never printed before : with remarks upon the proceedings in Parliament relating to that report, and some publick accounts in the said places which ought not to have been allowed.

Goldsmiths'-Kress no. 06584.3, suppl.

La Verona illustrata : ridotta in compendio, principalmente per uso de' forestieri, con varie aggiunte : premessa in ristretto la vita del marchese Scipione Maffei.

Includes bibliographical references and indexes.

Der Burgwart; Zeitschrift für Burgenkunde und mittelalterliche Baukunst.

Subtitle varies: v. 1-2, Zeitschrift für Burgenkunde und das ganze mittelalterliche Befestigungswesen.

Report of the Commission to locate the site of the frontier forts of Pennsylvania.

Miscellaneous after 1825.

Athens Mauern im IV. Jahrhundert v. Chr. ...

Lebenslauf.

Iwo Jima Photo Album, Image 40

A concealed Japanese fortification in a hill side. Caption; "Well hidden Japanese emplacements made it very rough going."

De la défense des états par les positions fortifiées /

Mode of access: Internet.

Report of the Board on Fortifications or Other Defenses appointed by the President of the United States under the provisions of the act of Congress approved March 3, 1885 ...

William C. Endicott, Secretary of War, President of the Board.

A rapid dietary assessment tool to determine intake of folate was developed and validated

Background and Objective: Estimates of dietary folate intake are currently of considerable interest, but no rapid tools are available to assess dietary intake of folate that are well suited to everyday health promotion activities, We developed and tested the reliability and validity of two prototypes of a rapid dietary assessment tool (a folate intake tool, FIT) to determine dietary intake of folate. Study Design and Setting: Five hundred and sixty eight men and women aged 33-93 years from Perth, Western Australia. Completed one of the two prototypes of the tool and gave a fasting blood sample for measurement of serum folate. A subset (n - 277) of participants completed the same tool on a second occasion 3-6 weeks later. Results: The Pearson correlations (r) between folate score from the tool and serum folate were moderately high for both prototypes (FIT-A r = 0.54-, FIT-B r = 0.49). The folate scores for the two prototypes were similar on repeat testing and correlated strongly (FIT-A r = 0.75; FIT-B r = 0.68). Conclusions: The rapid dietary assessment tool described here, FIT, provides a valid and reliable measurement of dietary intake of folate for both men and women. (c) 2005 Elsevier Inc. All rights reserved.

Investigation of the role of protein kinase C (PKC) in cytostasis induced by tumour promoting phorbol esters and related compounds

Protein kinase C (PKC) is considered to be the major receptor for tumour promoting phorbol esters such as 12-0- tetradecanoylphorbol-13-acetate (TPA). These agents evoke a plethora of biological effects on cells in culture. The growth of A549 human lung carcinoma cells maintained in medium fortified with 10% foetal calf serum (FCS) is arrested for 6 days by TPA and other biologically active phorbol esters. In the work described in this thesis, the hypothesis was tested that modulation of PKC activity is closely related to events pivotal for cytostasis to occur. The effect of several phorbol esters, of newly synthesized analogues of diacylglycerols (DAG) and of bryostatins (bryos) on cell growth and ability to modulate activity of PKC has been investigated.Determination of the subcellular distribution of PKC following treatment of cells with TPA and partial enzyme purification by non-denaturing poly-acrylamide gel electrophoresis revealed translocation of enzyme activity from cytosoUc to paniculate fraction. Chronic exposure of cells to TPA resulted in a time and concentration dependent degradation of enzyme activity. Synthetic DAG and DAG analogues, unable to arrest the growth of cells at non-toxic concentrations, were neither able to affect subcellular PKC distribution nor compete effectively for phorbol ester binding sites at physiologically relevant concentrations. Bryos 1,2,4 and 5, natural products, possessing antineoplastic activity in mice, elicited transient arrest of A549 cell growth in vitro. They successfully competed for phorbol ester receptors in A549 cells with exquisite affinity and induced a shift in sub-cellular PKC distribution, though not to the same extent as PTA. Enzyme down-regulation resulted from prolonged exposure of cells to nanomolar concentrations of bryos. In vivo studies demonstrated that neither PDBu nor bryo 1 was able to inhibit A549 xenograft growth in athymic mice. The growth of A549 cell populations cultured under conditions of serum-deprivation was inhibited only transiently by biologically active phorbol esters. Fortification of serum-free medium with EGF or fetuin was able to partially restore sensitivity to maintained growth arrest by PTA. PKC translocation to the paniculate cellular fraction and subsequent enzyme down-regulation, induced by TPA, occurred in a manner similar to that observed in serum-supplemented cells. However, total PKC activity and cytosolic phorbol ester binding potential were greatly reduced in the serum-deprived cell population. Western blot analysis using monospecific monoclonal antibodies revealed the presence of PKC-a in both A549 cell populations, with significantly reduced protein levels in serum- deprived cells. PKC-/9 was not detected in either cell population.