Smoking and All-cause Mortality in Older Adults: Results From the CHANCES Consortium

INTRODUCTION: Smoking is known to be a major cause of death among middle-aged adults, but evidence on its impact and the benefits of smoking cessation among older adults has remained limited. Therefore, we aimed to estimate the influence of smoking and smoking cessation on all-cause mortality in people aged ≥60 years.

METHODS: Relative mortality and mortality rate advancement periods (RAPs) were estimated by Cox proportional hazards models for the population-based prospective cohort studies from Europe and the U.S. (CHANCES [Consortium on Health and Ageing: Network of Cohorts in Europe and the U.S.]), and subsequently pooled by individual participant meta-analysis. Statistical analyses were performed from June 2013 to March 2014.

RESULTS: A total of 489,056 participants aged ≥60 years at baseline from 22 population-based cohort studies were included. Overall, 99,298 deaths were recorded. Current smokers had 2-fold and former smokers had 1.3-fold increased mortality compared with never smokers. These increases in mortality translated to RAPs of 6.4 (95% CI=4.8, 7.9) and 2.4 (95% CI=1.5, 3.4) years, respectively. A clear positive dose-response relationship was observed between number of currently smoked cigarettes and mortality. For former smokers, excess mortality and RAPs decreased with time since cessation, with RAPs of 3.9 (95% CI=3.0, 4.7), 2.7 (95% CI=1.8, 3.6), and 0.7 (95% CI=0.2, 1.1) for those who had quit <10, 10 to 19, and ≥20 years ago, respectively.

CONCLUSIONS: Smoking remains as a strong risk factor for premature mortality in older individuals and cessation remains beneficial even at advanced ages. Efforts to support smoking abstinence at all ages should be a public health priority.

The timing and spatiotemporal patterning of Neanderthal disappearance

ThetimingofNeanderthal disappearanceandtheextent to whichthey overlapped with the earliest incoming anatomically modern humans (AMHs)inEurasia arekey questions inpalaeoanthropology1,2 .Deter- mining the spatiotemporal relationship between the two populations is crucial if we are to understand the processes, timing and reasons leading to the disappearance of Neanderthals and the likelihood of cultural and genetic exchange. Serious technical challenges, however, havehinderedreliable datingof the period,as theradiocarbonmethod reaches its limit at 50,000 years ago3 .Herewe apply improved accel- erator mass spectrometry 14C techniques to construct robust chro- nologies from 40 key Mousterian and Neanderthal archaeological sites, ranging fromRussia toSpain.Bayesianagemodellingwas used togenerate probability distributionfunctions todetermine the latest appearancedate.Weshowthat theMousterianendedby41,030–39,260 calibratedyears BP(at95.4%probability) acrossEurope.Wealsodem- onstrate that succeeding ‘transitional’ archaeological industries, one ofwhich has beenlinked withNeanderthals (Cha ˆtelperronian)4 ,end at a similar time. Our data indicate that the disappearance of Nean- derthals occurred at different times in different regions.Comparing the data with results obtained fromthe earliest datedAMHsites in Europe, associated with the Uluzzian technocomplex5 , allows us to quantify the temporal overlap between the two human groups. The results revealasignificantoverlap of 2,600–5,400years (at 95.4%prob- ability).This hasimportant implications formodels seeking toexplain the cultural, technological and biological elements involved in the replacement of Neanderthals byAMHs.Amosaic of populations in Europe during the Middle to Upper Palaeolithic transition suggests that there was ample time for the transmission of cultural and sym- bolic behaviours, as well as possible genetic exchanges, between the two groups.

Habiter l’enfance approche de l’habitat dans les premiers récits d’Eugène Savitzkaya

L‘auteur entreprend l‘approche de l‘importance particulière du rapport aux espaces habités ou inhabités dans l‘imaginaire et la construction narrative des textes fictionnels de l‘écrivain belge francophone contemporain Eugène Savitzkaya de Mentir (1977) jusqu‘à En vie (1994). Il s‘agit de souligner la pertinence de l‘habitat en tant que support des imaginaires de l‘enfance et de la poétisation du quotidien. L‘espace s‘avère en effet un repère symbolique et poétique chez Savitzkaya ; ce qui lui permet de s‘exprimer et d‘exprimer son enfance sur un mode autofictionnel.

Sagrada melancolia

Pretende-se, com este Trabalho de Projecto, incitar a essa discussão o que acontece no que concerne à tradução de poesia, neste caso através da realização de uma tradução para a língua Inglesa da obra Sagrada Melancolia, de Sérgio Pereira. Mediante a discussão patente sobre a traduzibilidade da poesia, será esta impossível? Intraduzível? E, se possível, através de que metodologias, teorias e respectivas opções tradutivas? Para o presente Trabalho de Projecto foram consideradas e aplicadas as teorias de tradutores, linguistas e poetas, como John Dryden, Alexander Tytler, Eugène Nida, Roman Jakobson, Jean Paul Vinay e Jean Paul Darbelnet, Juliane House e Peter Newmark. Sendo a Poesia uma forma de Arte, a sua tradução será também Arte? Considera-se sugerir à editora a publicação da obra traduzida. Faz, também, parte deste Trabalho de Projecto a intenção de Localizar o blog Sagrada Melancolia para as línguas Inglesa, Francesa e Espanhola, em colaboração com o autor, Sérgio Pereira.

Recueil périodique de législation, de doctrine et de jurisprudence en matière de procédure civile, commerciale, criminelle et administrative / publié par MM. Rodolphe Rousseau,... Laisney,...

1900 (A21).

Recueil périodique de législation, de doctrine et de jurisprudence en matière de procédure civile, commerciale, criminelle et administrative / publié par MM. Rodolphe Rousseau,... Laisney,...

1916 (A37).

Recueil périodique de législation, de doctrine et de jurisprudence en matière de procédure civile, commerciale, criminelle et administrative / publié par MM. Rodolphe Rousseau,... Laisney,...

1892 (A13).

Recueil périodique de législation, de doctrine et de jurisprudence en matière de procédure civile, commerciale, criminelle et administrative / publié par MM. Rodolphe Rousseau,... Laisney,...

1913 (A34).

Recueil périodique de législation, de doctrine et de jurisprudence en matière de procédure civile, commerciale, criminelle et administrative / publié par MM. Rodolphe Rousseau,... Laisney,...

1899 (A20).

Recueil périodique de législation, de doctrine et de jurisprudence en matière de procédure civile, commerciale, criminelle et administrative / publié par MM. Rodolphe Rousseau,... Laisney,...

1880 (A1).

Recueil périodique de législation, de doctrine et de jurisprudence en matière de procédure civile, commerciale, criminelle et administrative / publié par MM. Rodolphe Rousseau,... Laisney,...

1896 (A17).

Recueil périodique de législation, de doctrine et de jurisprudence en matière de procédure civile, commerciale, criminelle et administrative / publié par MM. Rodolphe Rousseau,... Laisney,...

1893 (A14).

Recueil périodique de législation, de doctrine et de jurisprudence en matière de procédure civile, commerciale, criminelle et administrative / publié par MM. Rodolphe Rousseau,... Laisney,...

1888 (A9).

Recueil périodique de législation, de doctrine et de jurisprudence en matière de procédure civile, commerciale, criminelle et administrative / publié par MM. Rodolphe Rousseau,... Laisney,...

1885 (A6).