Selenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity.

The capacity of a polypeptide chain to engage in an amyloid formation process and cause a conformational disease is contained in its sequence. Some of the sequences undergoing fibrillation contain critical methionine (Met) residues which in vivo can be synthetically substituted by selenomethionine (SeM) and alter their properties.

Compositional data analysis of vote shares in the 2001 Australian Federal election

First application of compositional data analysis techniques to Australian election data

Brook Trout Removal as a Conservation Tool to Restore Eagle Lake Rainbow Trout

Nonnative brook trout Salvelinus fontinalis are abundant in Pine Creek and its main tributary, Bogard Spring Creek, California. These creeks historically provided the most spawning and rearing habitat for endemic Eagle Lake rainbow trout Oncorhynchus mykiss aquilarum. Three-pass electrofishing removal was conducted in 2007–2009 over the entire 2.8-km length of Bogard Spring Creek to determine whether brook trout removal was a feasible restoration tool and to document the life history characteristics of brook trout in a California meadow stream. After the first 2 years of removal, brook trout density and biomass were severely reduced from 15,803 to 1,192 fish/ha and from 277 to 31 kg/ha, respectively. Average removal efficiency was 92–97%, and most of the remaining fish were removed in the third year. The lack of a decrease in age-0 brook trout abundance between 2007 and 2008 after the removal of more than 4,000 adults in 2007 suggests compensatory reproduction of mature fish that survived and higher survival of age-0 fish. However, recruitment was greatly reduced after 2 years of removal and is likely to be even more depressed after the third year of removal assuming that immigration of fish from outside the creek continues to be minimal. Brook trout condition, growth, and fecundity indicated a stunted population at the start of the study, but all three features increased significantly every year, demonstrating compensatory effects. Although highly labor intensive, the use of electrofishing to eradicate brook trout may be feasible in Bogard Spring Creek and similar small streams if removal and monitoring are continued annually and if other control measures (e.g., construction of barriers) are implemented. Our evidence shows that if brook trout control measures continue and if only Eagle Lake rainbow trout are allowed access to the creek, then a self-sustaining population ofEagle Lake rainbow trout can become reestablished

Governmental Measures to Enhance the Finnish Innovation System to Respond to the Challenge of Mitigating Climate Change

Climate innovations, that cover both technological applications and process and service innovations, play a key role in climate change mitigation. The purpose of this study was to examine how the Finnish innovation system could be enhanced with governmental measures so that the diffusion of climate innovations could be speeded up. During the study, it became evident that the governmental measures need to support the whole innovation chain, which comprises of research, development, demonstration and deployment. Only this can lead to the successful birth and diffusion of low carbon innovations. The study found that the strengths of the Finnish innovation system are research and development, and the current national innovation policies strongly support these activities. However, these have been emphasised at the expense of the demonstration and deployment. Consequently, the biggest bottlenecks in the Finnish innovation landscape are the lack of pilot and demonstration projects and slow commercialisation, thus the high price of the innovation. To meet with the challenge, the government should firstly promote strict greenhouse gas emission reduction targets. This would boost up the innovation activities, which would also lower the prices of the innovations. To speed up the commercialisation process, measures that stimulate the domestic market, such as feed-in-tariffs and public procurements, are needed. Special attention should also be paid to the measures that could shift the traditional closed innovation chain towards open innovation. This means that the product development should involve experts from several fields such as the user and marketing experts to speed up the commercialisation. In addition, efficient innovation co-operation between both private and public sector is essential. Finally, as the domestic resources are not adequate for producing all the innovations needed, the domestic innovation activities should be focused on a few sectors, and at the same time promote efficient import policies.

Toivosta ja sitkeydestä

Kirjallisuusarvostelu

Maantiede poliisin apuna

Kirjallisuusarvostelu

MICROWAVE ACTIVATION OF IMMOBILIZED LIPASE FOR TRANSESTERIFICATION OF VEGETABLE OILS

This work investigated the effect of microwave irradiation (MW) on the ethanolysis rate of soybean and sunflower oils catalyzed by supported Novozyme 435 (Candida antarctica). The effects of tert-butanol, water addition and oil:ethanol molar ratio on transesterification were evaluated under conventional heating (CH), and under optimum reaction conditions (with no added water in the system, 10% tert-butanol and 3:1 ethanol-to-oil molar ratio). The reactions were monitored up to 24 h to determine the conditions of initial reaction velocity. The investigated variables under MW (50 W) were: reaction time (5.0-180 min) and mode of reactor operation (fixed power, dynamic and cycles) in the absence and presence of tert-butanol (10% (w/w). The measured response was the reaction conversion in ethyl esters, which was linked to the enzyme catalytic activity. The results indicated that the use of microwave improved the activity at fixed power mode. A positive effect of the association of tert-butanol and MW irradiation on the catalytic activity was observed. The reaction rate improved in the order of approximately 1.5 fold compared to that under CH with soybean oil. Using soybean oil, the enzymatic transesterification under MW for conversion to FAEE (fatty acid ethyl esters) reached >99% in 3h, while with the use of CH the conversions were about 57% under similar conditions.

Spara det finlandssvenska talet

Slutrapport

Työpaikkailmoitusten sisällön ja osaamisvaatimusten käsittely

Työpaikkailmoitusten etsiminen internetistä on hyvin yleistä nykyään, mutta kysei- nen prosessi ei ole kehittynyt vuosien varrella muiden palvelujen tapaan. Tämän ta- kia tehokkaan ja omiin taitoihin kohdistetun haun tekeminen on hyvin vaikeaa. Tässä työssä toteutetaan verkkopalvelu, jonka avulla käyttäjä voi tutkia useasta läh- teestä haettuja IT-alan työpaikkailmoituksia ja etsiä niistä omille taidoilleen parhai- ten sopivia. Palvelun taustalla toimiva järjestelmä hakee ilmoitukset ja analysoi ne tarvittavan datan saamiseksi. Samalla ilmoituksista luodaan tilastoja, joita käyttäjät voivat tutkia. Kerätyistä tiedoista saadaan myös selville millaisia yhteyksiä eri am- mattien ja termien välillä on. Palvelun avulla on helppoa tehdä hakuja painottaen omia osaamisalueita. Haun tu- lokset tulostetaan parhaiten sopivasta huonoimmin sopivaan. Jokaisen ilmoituksen mukana tulostetaan listaus ilmoituksessa olleista ammattitermeistä ja jokaisen haun loppuun tulostetaan myös listaus kaikista haun tuloksista löytyneistä ilmoituksista. Kohdistetut haut ovat mahdollisia, koska palvelu kerää tietoja ilmoituksista löytyvis- tä termeistä luokitellen niitä. Tilastoista käyttäjällä on mahdollisuus seurata työpaikkailmoitusmäärien muutoksia viikoittain niin mol:n kuin monsterin järjestelmissä. Pelkkien ilmoitusmäärien lisäksi tilastoista voi seurata yksittäisten ammattitermien esiintymistä, sekä tietyn ammat- tialan ilmoitusten määriä.

Raiskauksen maantieteestä

Kirjallisuusarvostelu

Hälsans grund kan bara hjärtat förstå : ett sökande efter kunskap om hälsa i ljuset av Blaise Pascals tänkande

The aim of this thesis is to gain new understanding of health based on the work Penseés (Thoughts) by Blaise Pascal. The research interest originates from the motive of the heart for the greatness of man in conjunction with his baseness. The study is hermeneutic and the purpose is to describe health formulated as new abductive theses based on the assumption that caring science and caring theology can be conjoined in the same ontology. The work Penseés is, in Gadamer’s sense, alive since the text is constantly being made use of and is in this occurence interpreted through the requirements made by caring science. Pascal’s arguments continue through the historically effected consciousness while the interpretation is confronted with the ontological model of health. In the initial horizon we find the understanding of the motion of health and the extension towards text materials which is undertaken by Pascal’s Penseés. to open up the perspective and be able to project the horizon of the text. In the encounter with the text, the core content will first be discussed in an interpretative part after which the understanding gained will be summarized into new abductive assumptions. On the basis of Gadamer’s emphasis on the applications of the interpretations, the merging of the horizons will identify health as something desired by man, what he is and what he wants to accomplish. The creation of health is the reason of the heart, and on the basis of what man wants to confide in, the rise of health will be established. The totality of greatness and baseness of man is achieved by the accomplishment of health. That man owns spiritual devotedness means health whereas unhealthy means that he is insecure of his character and leads a life with ill-considered amusements. When according to Pascal, man’s desires and thoughts are joined in the heart, a connecting relation will arise. Hence the spiritual edification that man will fail to secure if he puts too much of his confidence in transient reason is included, something that is insufficient when it comes to understand the meaning of health.

Avaliação patogênica in vitro de Pythium middletonii Sparrow e Pythium dissotocum Drechsler em alface

Infecções radiculares nos cultivos hidropônicos de alface são frequentes e, na maior parte das vezes, causadas por espécies de Pythium, extremamente bem adaptadas ao ambiente aquático. Este estudo buscou avaliar o potencial patogênico in vitro de Pythium middletonii e P. dissotocum, em quatro cultivares de alface: Elisa (lisa), Vera (crespa), Mimosa (mimosa) e Tainá (americana). Sementes de alface, de cada cultivar, foram desinfetadas superficialmente, pré-germinadas por 24 horas, e colocadas na superfície do meio ágar-água. Em seguida, um disco de micélio dos isolados de Pythium, foi disposto no centro de cada placa. Placas contendo apenas as sementes de alface serviram como controle. O delineamento experimental utilizado foi inteiramente casualizado, com cinco repetições, sendo cada uma delas representada por uma placa de Petri. Avaliou-se o comprimento dos hipocótilos, das radículas e a porcentagem das plântulas sobreviventes após dez dias de incubação. O experimento foi conduzido na temperatura ideal de crescimento da alface (20ºC), e nas ideais para o crescimento dos isolados, 23ºC para P. middletonii e 27ºC para P. dissotocum. A 20ºC, P. dissotocum foi mais patogênico que P. middletonii, reduzindo significativamente o comprimento dos hipocótilos e, principalmente, das radículas, de praticamente todas as cultivares. Na temperatura de 27ºC, P. dissotocum foi responsável pela mais baixa porcentagem de plântulas sobreviventes entre as cultivares, sendo mais patogênico em Vera (54% de sobrevivência). Dentre as cultivares analisadas, a Mimosa mostrou tendência de menor suscetibilidade a este patógeno, apresentando a maior porcentagem de plântulas sobreviventes e o maior comprimento das radículas em relação ao controle. P. dissotocum apresentou maior crescimento micelial e foi mais patogênico que P. middletonii em todos os experimentos realizados.

Podridão de raízes causada por Pythium aphanidermatum, em cultivares de alface produzidas em sistema hidropônico

A podridão de raízes, causada por Pythium aphanidermatum e outras espécies de Pythium, é a principal doença da alface cultivada em sistemas hidropônicos no Brasil. O presente trabalho teve como objetivo avaliar quatro cultivares comerciais de alface em relação à sensibilidade a podridão de raízes, causada por P. aphanidermatum. Os estudos foram realizados em placas de Petri contendo ágar-água com plântulas de alface das cultivares crespa (Vera e Verônica) e lisa (Regina e Elisa), infestadas ou não com o patógeno. Com as mesmas cultivares foram realizados quatro experimentos em sistemas hidropônicos (Nutrient Film Technique), sendo dois em estufa coberta com plástico e sombrite e dois em estufa coberta apenas com plástico. As plântulas, infectadas ou não com P. aphanidermatum, foram transplantadas para os sistemas infestados ou não. Foi avaliada a severidade da doença e o desenvolvimento das plantas. Todas as cultivares foram suscetíveis à podridão de raízes nos experimentos realizados in vitro e in vivo. A presença do sombrite não reduziu a podridão de raízes em cultivares de alface produzidas no sistema hidropônico. A cultivar Regina apresentou maior massa de matéria seca da parte aérea e das raízes, na presença ou ausência do patógeno, sendo a mais indicada para o cultivo hidropônico na época mais quente do ano.