The Amplifier - v. 7, no. 10

In this issue...Mineral Club, Barite, Engineer Exam, Montana State Highway Commission, Career Day, lung cancer, Selective Service, Civil War, Brown's Gulch

The Amplifier - v. 7, no. 11

In this issue...Coed Club, Coach Simonich, Georgetown Lake, Saint Patrick's Day, thermoelectricity, Peace Corps, Anaconda, Montana, Dan Rovig

The Amplifier - v. 7, no. 12

In this issue...National Audubon Society, Newman Club, Mineral Club, Paul Harvey, Glee Club, Marcus Daly, American Legion, Montana Standard, National Science Foundation

The Amplifier - v. 7, no. 13

In this issue...Leonard Field, Copper Guards, M-Days, Geology Field Trip, Columbia Riding Club, U.S. Army, International Club, Bob Johnson, Carroll College

The Amplifier - v. 7, no. 14

In this issue...Paul Harvey, Student Wives Club, Magma, Anaconda, Dick Crnich, John Birch Society, Coed Club, Yellowstone Park, Montana Power, Ed Speelman

The Amplifier - v. 7, no. 15

In this issue...Camera Club, Magma, Hauser Lake, Newman Club, Montana Central Railway, Cal Strobel, blood donations, Peace Corps, Paul Harvey, Pan American Oil Company

Multi-parametric classification of Alzheimer's disease and mild cognitive impairment: the impact of quantitative magnetization transfer MR imaging

Multi-parametric and quantitative magnetic resonance imaging (MRI) techniques have come into the focus of interest, both as a research and diagnostic modality for the evaluation of patients suffering from mild cognitive decline and overt dementia. In this study we address the question, if disease related quantitative magnetization transfer effects (qMT) within the intra- and extracellular matrices of the hippocampus may aid in the differentiation between clinically diagnosed patients with Alzheimer disease (AD), patients with mild cognitive impairment (MCI) and healthy controls. We evaluated 22 patients with AD (n=12) and MCI (n=10) and 22 healthy elderly (n=12) and younger (n=10) controls with multi-parametric MRI. Neuropsychological testing was performed in patients and elderly controls (n=34). In order to quantify the qMT effects, the absorption spectrum was sampled at relevant off-resonance frequencies. The qMT-parameters were calculated according to a two-pool spin-bath model including the T1- and T2 relaxation parameters of the free pool, determined in separate experiments. Histograms (fixed bin-size) of the normalized qMT-parameter values (z-scores) within the anterior and posterior hippocampus (hippocampal head and body) were subjected to a fuzzy-c-means classification algorithm with downstreamed PCA projection. The within-cluster sums of point-to-centroid distances were used to examine the effects of qMT- and diffusion anisotropy parameters on the discrimination of healthy volunteers, patients with Alzheimer and MCIs. The qMT-parameters T2(r) (T2 of the restricted pool) and F (fractional pool size) differentiated between the three groups (control, MCI and AD) in the anterior hippocampus. In our cohort, the MT ratio, as proposed in previous reports, did not differentiate between MCI and AD or healthy controls and MCI, but between healthy controls and AD.

The Amplifier - v. 8, no. 1

In this issue...Copper Guard, Homecoming, Sigma Rho, Mountain View Methodist Church, Faculty Wives, Phil Judd, Glee Club, Mineral Club, Great Northern Railway

The Amplifier - v. 8, no. 2

In this issue...United Nations meeting, Newman Club, Sylvia White, Veteran's Day, Glee Club, Montana Power Company, Harvest Festival Dance, Joe Knuckey's Melody Makers

The Amplifier - v. 8, no. 3

In this issue...Thanksgiving, Fallout Shelters, Petroleum Engineering, Alumni News, Columbia Riding Club, Debate Team, The March of Dimes, National College Queen

The Amplifier- v. 8, no. 4

In this issue...Anaconda Railroad, Professor Stout, International Club, Hord's Jewelry, KXLF Television station, Coed Club, cyclone fence, Ray Kotow

The Amplifier - v. 8, no. 5

In this issue...Fish and Game Commission, Peace Corps, Great Falls Brewery, George D. McDonald, Glee club, Intramural basketball, Sugar Bowl, Metals Bank

The Amplifier - v. 8, no. 6

In this issue...Sylvia White, Speed Skating, President Kennedy, St. John's Church, Mineral Club, Magma Yearbook, Honor roll, Montana Power Company

The Amplifier - v. 8, no. 7

In this issue...Magma Yearbook, Marvin Senne, Continental Oil Company, NASA, Circle K Club, Mine Rescue training, Walter Mitty, International Club, Stu Stadler

The Amplifier - v. 8, no. 8

In this issue...Butte Civic Orchestra, bed protest, St. Patrick's Day mixer, Coed Club, Mickey O'Brien, baseball, chemistry, Main Hall, United States Senator, Barry Goldwater