SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools.

BACKGROUND: Qualitative frameworks, especially those based on the logical discrete formalism, are increasingly used to model regulatory and signalling networks. A major advantage of these frameworks is that they do not require precise quantitative data, and that they are well-suited for studies of large networks. While numerous groups have developed specific computational tools that provide original methods to analyse qualitative models, a standard format to exchange qualitative models has been missing. RESULTS: We present the Systems Biology Markup Language (SBML) Qualitative Models Package ("qual"), an extension of the SBML Level 3 standard designed for computer representation of qualitative models of biological networks. We demonstrate the interoperability of models via SBML qual through the analysis of a specific signalling network by three independent software tools. Furthermore, the collective effort to define the SBML qual format paved the way for the development of LogicalModel, an open-source model library, which will facilitate the adoption of the format as well as the collaborative development of algorithms to analyse qualitative models. CONCLUSIONS: SBML qual allows the exchange of qualitative models among a number of complementary software tools. SBML qual has the potential to promote collaborative work on the development of novel computational approaches, as well as on the specification and the analysis of comprehensive qualitative models of regulatory and signalling networks.

Iowa Budget Book Fiscal Year 2011.

Our FY 2011 General Fund budget is balanced, fiscally conservative, and does not raise sales or income taxes. We have already proposed and signed three balanced state budgets and have demonstrated the leadership to ensure that the current year (FY 2010) budget is balanced in the face of dramatic and quick declines in state revenues last year that occurred as a result of the national recession.

The 2001 Iowa Health Fact Book.

State-wide data relating to health outcomes, social determinants of health, health behaviors, and health care resources are presented, generally at the county level. The data have been compiled in this book, but were collected using different methodologies by various organizations and reporting mechanisms.

The 2003 Iowa Health Fact Book.

State-wide data relating to health outcomes, social determinants of health, health behaviors, and health care resources are presented, generally at the county level. The data have been compiled in this book, but were collected using different methodologies by various organizations and reporting mechanisms.

The 2005 Iowa Health Fact Book.

State-wide data relating to health outcomes, social determinants of health, health behaviors, and health care resources are presented, generally at the county level. The data have been compiled in this book, but were collected using different methodologies by various organizations and reporting mechanisms.

The 2007 Iowa Health Fact Book.

State-wide data relating to health outcomes, social determinants of health, health behaviors, and health care resources are presented, generally at the county level. The data have been compiled in this book, but were collected using different methodologies by various organizations and reporting mechanisms.

The 2009 Iowa Health Fact Book.

State-wide data relating to health outcomes, social determinants of health, health behaviors, and health care resources are presented, generally at the county level. The data have been compiled in this book, but were collected using different methodologies by various organizations and reporting mechanisms.

The 2011 Iowa Health Fact Book.

State-wide data relating to health outcomes, social determinants of health, health behaviors, and health care resources are presented, generally at the county level. The data have been compiled in this book, but were collected using different methodologies by various organizations and reporting mechanisms.

Flying Activity Book, 2011

Coloring and activity book for children produced by the Iowa Department of Transportation Aviation Department.

The Indians called it beautiful land : your quick-fact book : Iowa, a place to grow,1975.

A pocket sized brochure containing brief information on Iowa's history, industry, agriculture, tourism, quality of life, transportation, exports for the world market, people, education and basic facts.