982 resultados para Biology, Bioinformatics|Computer Science


Relevância:

100.00% 100.00%

Publicador:

Resumo:

Includes bibliographical references.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

"December 12, 1955"

Relevância:

100.00% 100.00%

Publicador:

Resumo:

"This work has been supported by Contract N6ori-71 Task XXIV United States Navy ONR NR 048 094"

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Thesis (M.S.)--University of Illinois.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

"C00-1018-1194."

Relevância:

100.00% 100.00%

Publicador:

Resumo:

"April 1, 1969."

Relevância:

100.00% 100.00%

Publicador:

Resumo:

"This work was supported by Contract AT(11-1)-1018 with the U.S. Atomic Energy Commission through September 30, 1970. Current support is under Contract AV(11-1)-2118 with the above agency."

Relevância:

100.00% 100.00%

Publicador:

Resumo:

At head of title: Boston Monday lectures.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Thesis (Ph.D.)--University of Washington, 2016-06

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Thesis (Ph.D.)--University of Washington, 2016-06

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Cyclic peptides containing oxazole and thiazole heterocycles have been examined for their capacity to be used as scaffolds in larger, more complex, protein-like structures. Both the macrocyclic scaffolds and the supramolecular structures derived therefrom have been visualised by molecular modelling techniques. These molecules are too symmetrical to examine structurally by NMR spectroscopy. The cyclic hexapeptide ([Aaa-Thz](3), [Aaa-Oxz](3)) and cyclic octapeptide ([Aaa-Thz](4), [Aaa-Oxz](4)) analogues are composed of dipeptide surrogates (Aaa: amino acid, Thz: thiazole, Oxz: oxazole) derived from intramolecular condensation of cysteine or serine/threonine side chains in dipeptides like Aaa-Cys, Aaa-Ser and Aaa-Thr. The five-membered heterocyclic rings, like thiazole, oxazole and reduced analogues like thiazoline, thiazolidine and oxazoline have profound influences on the structures and bioactivities of cyclic peptides derived therefrom. This work suggests that such constrained cyclic peptides can be used as scaffolds to create a range of novel protein-like supramolecular structures (e.g. cylinders, troughs, cones, multi-loop structures, helix bundles) that are comparable in size, shape and composition to bioactive surfaces of proteins. They may therefore represent interesting starting points for the design of novel artificial proteins and artificial enzymes. (C) 2002 Elsevier Science Inc. All rights reserved.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Purpose: The aim of this project was to design and evaluate a system that would produce tailored information for stroke patients and their carers, customised according to their informational needs, and facilitate communication between the patient and, health professional. Method: A human factors development approach was used to develop a computer system, which dynamically compiles stroke education booklets for patients and carers. Patients and carers are able to select the topics about which they wish to receive information, the amount of information they want, and the font size of the printed booklet. The system is designed so that the health professional interacts with it, thereby providing opportunities for communication between the health professional and patient/carer at a number of points in time. Results: Preliminary evaluation of the system by health professionals, patients and carers was positive. A randomised controlled trial that examines the effect of the system on patient and carer outcomes is underway. (C) 2004 Elsevier Ireland Ltd. All rights reserved.