974 resultados para Anton
Resumo:
In most psychological tests and questionnaires, a test score is obtained bytaking the sum of the item scores. In virtually all cases where the test orquestionnaire contains multidimensional forced-choice items, this traditionalscoring method is also applied. We argue that the summation of scores obtained with multidimensional forced-choice items produces uninterpretabletest scores. Therefore, we propose three alternative scoring methods: a weakand a strict rank preserving scoring method, which both allow an ordinalinterpretation of test scores; and a ratio preserving scoring method, whichallows a proportional interpretation of test scores. Each proposed scoringmethod yields an index for each respondent indicating the degree to whichthe response pattern is inconsistent. Analysis of real data showed that withrespect to rank preservation, the weak and strict rank preserving methodresulted in lower inconsistency indices than the traditional scoring method;with respect to ratio preservation, the ratio preserving scoring method resulted in lower inconsistency indices than the traditional scoring method
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The main instrument used in psychological measurement is the self-report questionnaire. One of its majordrawbacks however is its susceptibility to response biases. A known strategy to control these biases hasbeen the use of so-called ipsative items. Ipsative items are items that require the respondent to makebetween-scale comparisons within each item. The selected option determines to which scale the weight ofthe answer is attributed. Consequently in questionnaires only consisting of ipsative items everyrespondent is allotted an equal amount, i.e. the total score, that each can distribute differently over thescales. Therefore this type of response format yields data that can be considered compositional from itsinception.Methodological oriented psychologists have heavily criticized this type of item format, since the resultingdata is also marked by the associated unfavourable statistical properties. Nevertheless, clinicians havekept using these questionnaires to their satisfaction. This investigation therefore aims to evaluate bothpositions and addresses the similarities and differences between the two data collection methods. Theultimate objective is to formulate a guideline when to use which type of item format.The comparison is based on data obtained with both an ipsative and normative version of threepsychological questionnaires, which were administered to 502 first-year students in psychology accordingto a balanced within-subjects design. Previous research only compared the direct ipsative scale scoreswith the derived ipsative scale scores. The use of compositional data analysis techniques also enables oneto compare derived normative score ratios with direct normative score ratios. The addition of the secondcomparison not only offers the advantage of a better-balanced research strategy. In principle it also allowsfor parametric testing in the evaluation
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Es pot parlar de desafecció de la societat catalana envers els infants i els joves? Com es manifesta aquesta desafecció en l’àmbit de la cultura institucional? A partir d’una aproximació als serveis educatius de vint equipaments culturals de la ciutat de Barcelona, aquest treball proposa un seguit de dades, indicadors i observacions per assajar una resposta a aquestes qüestions
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BACKGROUND Socio-economic inequalities in mortality are observed at the country level in both North America and Europe. The purpose of this work is to investigate the contribution of specific risk factors to social inequalities in cause-specific mortality using a large multi-country cohort of Europeans. METHODS A total of 3,456,689 person/years follow-up of the European Prospective Investigation into Cancer and Nutrition (EPIC) was analysed. Educational level of subjects coming from 9 European countries was recorded as proxy for socio-economic status (SES). Cox proportional hazard model's with a step-wise inclusion of explanatory variables were used to explore the association between SES and mortality; a Relative Index of Inequality (RII) was calculated as measure of relative inequality. RESULTS Total mortality among men with the highest education level is reduced by 43% compared to men with the lowest (HR 0.57, 95% C.I. 0.52-0.61); among women by 29% (HR 0.71, 95% C.I. 0.64-0.78). The risk reduction was attenuated by 7% in men and 3% in women by the introduction of smoking and to a lesser extent (2% in men and 3% in women) by introducing body mass index and additional explanatory variables (alcohol consumption, leisure physical activity, fruit and vegetable intake) (3% in men and 5% in women). Social inequalities were highly statistically significant for all causes of death examined in men. In women, social inequalities were less strong, but statistically significant for all causes of death except for cancer-related mortality and injuries. DISCUSSION In this European study, substantial social inequalities in mortality among European men and women which cannot be fully explained away by accounting for known common risk factors for chronic diseases are reported.
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Vegeu el resum a l'inici del document del fitxer adjunt.
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Aquest projecte té com a objectiu la creació d'una aplicació informàtica de gestió de baix cost per a petits tallers de reparació d'automòbils per tal que puguin gestionar els seus clients i facturar les reparacions de vehicles automòbils.
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Breakthrough cancer pain is defined as transient pain exacerbation in patients with stable and controlled basal pain. Although variable, the prevalence of breakthrough cancer pain is high (33%-95%). According to the American Pain Foundation, breakthrough pain is observed in 50%-90% of all hospitalized cancer patients, in 89% of all patients admitted to homes for the elderly and terminal-patient care centers, and in 35% of all ambulatory care cancer patients. The management of breakthrough cancer pain should involve an interdisciplinary and multimodal approach. The introduction of new fentanyl formulations has represented a great advance and has notably improved treatment. Among these, the pectin-based intranasal formulation adjusts very well to the profile of breakthrough pain attacks, is effective, has a good toxicity profile, and allows for convenient dosing - affording rapid and effective analgesia with the added advantage of being easily administered by caregivers when patients are unable to collaborate.
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The lanthanide binuclear helicate [Eu(2)(L(C2(CO(2)H)))(3)] is coupled to avidin to yield a luminescent bioconjugate EuB1 (Q = 9.3%, tau((5)D(0)) = 2.17 ms). MALDI/TOF mass spectrometry confirms the covalent binding of the Eu chelate and UV-visible spectroscopy allows one to determine a luminophore/protein ratio equal to 3.2. Bio-affinity assays involving the recognition of a mucin-like protein expressed on human breast cancer MCF-7 cells by a biotinylated monoclonal antibody 5D10 to which EuB1 is attached via avidin-biotin coupling demonstrate that (i) avidin activity is little affected by the coupling reaction and (ii) detection limits obtained by time-resolved (TR) luminescence with EuB1 and a commercial Eu-avidin conjugate are one order of magnitude lower than those of an organic conjugate (FITC-streptavidin). In the second part of the paper, conditions for growing MCF-7 cells in 100-200 microm wide microchannels engraved in PDMS are established; we demonstrate that EuB1 can be applied as effectively on this lab-on-a-chip device for the detection of tumour-associated antigens as on MCF-7 cells grown in normal culture vials. In order to exploit the versatility of the ligand used for self-assembling [Ln(2)(L(C2(CO(2)H)))(3)] helicates, which sensitizes the luminescence of both Eu(III) and Tb(III) ions, a dual on-chip assay is proposed in which estrogen receptors (ERs) and human epidermal growth factor receptors (Her2/neu) can be simultaneously detected on human breast cancer tissue sections. The Ln helicates are coupled to two secondary antibodies: ERs are visualized by red-emitting EuB4 using goat anti-mouse IgG and Her2/neu receptors by green-emitting TbB5 using goat anti-rabbit IgG. The fact that the assay is more than 6 times faster and requires 5 times less reactants than conventional immunohistochemical assays provides essential advantages over conventional immunohistochemistry for future clinical biomarker detection.
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The production of fully functional human red cells in vitro from haematopoietic stem cells (hHSCs) has been successfully achieved. Recently, the use of hHSCs from cord blood represented a major improvement to develop the continuous culture system for Plasmodium vivax. Here, we demonstrated that CD34+hHSCs from peripheral blood and bone marrow can be expanded and differentiated to reticulocytes using a novel stromal cell. Moreover, these reticulocytes and mature red blood cells express surface markers for entrance of malaria parasites contain adult haemoglobin and are also permissive to invasion by P. vivax and Plasmodium falciparum parasites.
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During more than 20 years organisations like Gesto por la Paz and Lokarri had been trying to change the social approach to violence, instilling values of peace and dialogue. This working paper defends the idea that the work of these two organisations is key to understand the end of ETA violence and the lack of support that political violence has in the Basque Country. It develops the Basque peace frame generated by this movement and explains how this frame is present in the different levels of Basque society, changing the way political collective identities are negotiated in the Basque Country. Ultimately, their effort is to propose another way of doing politics, one where nationalism and violence are not intrinsically united, escaping from the polarization and confrontation that were in place during the 80s-90s.
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Aquest projecte permet confeccionar proves o qüestionaris que les persones respondran fent servir un navegador web i que calcularà els resultats de forma automàtica per ser gestionats a posteriori.
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Estudi del camp de golf PGA Catalunya de Caldes de Malavella, l’aigua de reg, ús de models nòrdics poc adequats al clima mediterrani, tipus de gespa i integració del camp al medi. Es proposen una sèrie de mesures per tal de millorar l’eficiència dels diferents processos i obtenir així un benefici ambiental i econòmic
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Insinöörityön tavoitteena oli tehdä teknis-taloudellinen selvitystyö pienvesivoimasta Vuosaaren B-voimalaitokselle. Ensimmäiseksi täytyi selvittää laitoksen virtausolosuhteet, putouskorkeus, saavutettavissa oleva teho, konkreettinen sijoittumispaikka laitoksessa, tarvittavat rakenteet, laitteistot, sähköistys ja ohjausjärjestelmät sekä näiden kaikkien kustannukset. Työn alkuosassa käsitellään vesivoimaloiden teoriaa ja niihin liittyviä yleisiä asioita. Loppuosassa tarkastellaan Vuosaaren B-voimalaitosta sekä varsinaista teknis-taloudellista selvitystyötä. Työn teoriaosuuteen tietoja hankittiin kirjallisuudesta sekä Internetistä. Varsinaisessa selvitystyössä tietojen hankkimisessa auttoivat Helsingin Energian sekä muiden yritysten asiantuntijat. Selvitettyjen alkuarvojen ja muiden tietojen perusteella pystyttiin lopuksi tekemään yleisarvio kannattavuudesta sekä arvio investointien kannattavuudesta. Työssä käsiteltiin seuraavia toteutettavissa olleita vaihtoehtoja: yksi turbiini, kaksi turbiinia tai ei turbiinia ollenkaan. Yhdellä turbiinilla vuotuinen käyttöaika olisi ollut laitoksen käyttötietojen perusteella noin 7500 tuntia vuodessa. Kahden turbiinin vaihtoehdossa yhtä turbiinia olisi käytetty 6000 tuntia vuodessa ja kahden turbiinin yhteiskäyttöaika olisi jäänyt vain 1500 tuntiin vuodessa. Näistä syistä johtuen parhaaksi ratkaisuksi muodostui yhden turbiinin vaihtoehto, jossa turbiinin käyttöaika oli optimaalinen ja investointikustannukset pysyivät kohtuullisina. Turbiinin pois jättäminen ei myöskään olisi järkevää, koska turbiinin avulla laitoksen energia tehokkuus paranisi. Selvitystyön avulla Helsingin Energia voi tehdä päätöksen pienvesivoimalaan investoimisesta, mikä selvityksen perusteella vaikuttaisi kannattavalta.
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Amb l’objectiu d’analitzar i comprendre d’una manera més adequada els mecanismes pels quals els potencials turistes que venen d’Anglaterra prenen la decisió de viatjar fins la Costa Daurada, en el context de la introducció de les línies aèries de baix cost a Espanya i la creació de noves rutes, s’ha dut a terme una enquesta a l’aeroport de Reus a un total de 445 turistes que estaven a punt de tornar de les seves vacances cap a Anglaterra tenint l'aeroport d'East Midlands (EMA) com a destinació i viatjant amb la companyia aèria de baix cost RyanAir. Amb el mètode utilitzat en aquest projecte s'ha mesurat, per mitjà de l'enquesta esmentada, el pes de la causalitat entre la presència de vols barats des de EMA fins a Reus amb la decisió dels turistes de passar les seves vacances en una regió turística de primer ordre a Catalunya com és la Costa Daurada. Segons els resultats de les dues preguntes causals que formen part de l’enquesta (pregunta 18 i pregunta 19), gairebé un 30% de l'impacte econòmic turístic total és degut a la disponibilitat de vols barats mitjançant RyanAir. Tanmateix, al voltant d’un 60% de l'impacte estaria relacionat amb el fet que els turistes visitarien la Costa Daurada independentment de la disponibilitat de vols de RyanAir. Això indicaria que tot i que els vols de Ryanair són innegablement atractius pels turistes, hi ha un desig important de visitar la Costa Daurada que podria ser satisfet per altres mitjans.