Geological explorations in Central Borneo (1893-94) : Borneo expedition. english rev. ed. with an appendix on fossil radiolaria of Central-Borneo ([Reprod.]) / by Dr. G. A. F. Molengraaff,... ; by Dr. G. J. Hinde

Comprend : Description of fossil radiolaria from the rocks of Central Borneo, obtained by prof. Dr. G. A. F. Molengraaff in the dutch exploring expedition of 1893-94

Recherches sur la craie supérieure. Première partie, Stratigraphie générale. Première partie, Stratigraphie générale, Fascicule I / par A. de Grossouvre,... ; [ed.] Ministère des travaux publics, [Service de la carte géologique de la France]

Collection : Mémoires pour servir à l'explication de la carte géologique détaillée de la France

Recherches sur la craie supérieure. Première partie, Stratigraphie générale. Première partie, Stratigraphie générale, Fascicule II / par A. de Grossouvre,... ; [ed.] Ministère des travaux publics, [Service de la carte géologique de la France]

Collection : Mémoires pour servir à l'explication de la carte géologique détaillée de la France

The impact of fibrosis and steatosis on early viral kinetics in HCV genotype 1-infected patients treated with Peg-IFN-alfa-2a and ribavirin.

Summary.  Hepatitis C viral (HCV) kinetics after initiation of interferon-based therapy provide valuable insights for understanding virus pathogenesis, evaluating treatment antiviral effectiveness and predicting treatment outcome. Adverse effects of liver fibrosis and steatosis on sustained virological response have been frequently reported, yet their impacts on the early viral kinetics remain unclear. In this study, associations between histology status and early viral kinetics were assessed in 149 HCV genotype 1-infected patients treated with pegylated interferon alfa-2a and ribavirin (DITTO trial). In multivariate analyses adjusted for critical factors such as IL28B genotype and baseline viral load, presence of significant fibrosis (Ishak stage > 2) was found to independently reduce the odds of achieving an initial reduction (calculated from day 0 to day 4) in HCV RNA of ≥2 logIU/mL (adjusted OR 0.03, P = 0.004) but was not associated with the second-phase slope of viral decline (calculated from day 8 to day 29). On the contrary, presence of liver steatosis was an independent risk factor for not having a rapid second-phase slope, that is, ≥0.3 logIU/mL/week (adjusted OR 0.22, P = 0.012) but was not associated with the first-phase decline. Viral kinetic modelling theory suggests that significant fibrosis primarily impairs the treatment antiviral effectiveness in blocking viral production by infected cells, whereas the presence of steatosis is associated with a lower net loss of infected cells. Further studies will be necessary to identify the biological mechanisms underlain by these findings.

Vastaus sisäasiainministerinä ed. E. Kilven kysymykseen, joka koskee pidätettyjen kohtaloa

Puhe

Med Ed Update, September, 2006

News for the University of Iowa Medical Education Community, produced by Office by Students Affairs and Curriculum.

Vastaus ed. Wickmanin kysymykseen erään kunnan nimen muuttamisesta

Puhe

Vastaus ed. K. Anderssonin kysymykseen, joka koskee toimenpiteitä 4 päivänä heinäkuuta 1944 sotaväen rikoslain muuttamisesta annetun lain kumoamiseksi

Puhe 4.7.1944

Methodus legendi cognoscendique historiam tam sacram quam profanam. Accessit oratio de historiae dignitate... item panegyricus scriptus in honorem festivitatis qua... Henricus Julius,... in episcopatus Mindensis possessionem indulcebatur, auctore Reinero Reineccio Steinhemio. Ad calcem addita est Commentiuncula ["sic"] de Widechindo Magno, rege Saxon., dynasta Angrivariorum, etc. Editio 2a. [Reinero Reineccio historico in inclyta Acad. Julia amico colendo. S. P. D. David Chytraeus. In methodum historicam Reineri Reineccii Carmen Simonis Mencii. Historiae et Reineri Reineccii genio, Arnoldus Freitagius. Historiae encomium per Andream Alciatum. De Westphalorum Saxonia et Widechindo Magno, etc., Petrus Lotichius secundus. De eodem Widechindo Magno Michael Bojemus.]

Comprend : Historiae encomium... ad Galeacium vice-comitem scriptum ; Clarissimo... viro Reinero Reineccio... principis Brunovicensis etc. historico, in inclyta acad. Julia, amico colendo s. p. d. David Chytraeus ; Historiae et cl. viri Reineri Reineccii genio Arnoldus Freitagius ; De Westphalorum Saxonia et Widechindo Magno etc. Petrus Lotichius Secundus ; In Methodum historicam... Reineri Reineccii Carmen ; De... Widechindo Magno Michael Bojemus

Vastaus ed. Kuusisen ym. välikysymykseen, joka koskee viimeaikaista talouspolitiikkaa

Puhe

Un programa de atención multidisciplinar al paciente con hepatitis crónica C mejora la eficacia del tratamiento con peginterferon alfa-2a y ribavirina.

La adherencia al tratamiento antiviral de la hepatitis crónica C (HCC) es una variable importante en la obtención de la respuesta viral sostenida (RVS). El objetivo de este trabajo es evaluar el impacto de un programa de atención multidisciplinar (PAM) en la adherencia y eficacia del tratamiento de la HCC. Se incluyeron 447 pacientes tratados con peginterferón-alfa-2a y ribavirina y se clasificaron en tres grupos: grupo control (2003-2004, n=147), grupo PAM (2005-2006, n=131) y grupo Validación-PAM (2007-2009, n=169). La adherencia y los porcentajes de RVS fueron superiores en los pacientes incluidos en los grupos PAM (94.6% y 77.1%) y Validación-PAM (91.7% y 74.6%) en comparación con el grupo control (78.9% y 61.9%) (p<0.05 para todos los casos).