Francesco Grimaldi, un mercader-banquero genovés entre Granada, la corte e Inglaterra (siglos xv-xvi)

Los estudios sobre la comunidad genovesa del Reino de Granada suelen centrarse en las actividades desarrolladas en el territorio y rara vez en la reconstrucción de trayectorias individuales, circunstancia determinada por el recurso casi exclusivo a los protocolos notariales. El caso de Francesco Grimaldi es singular por muchas razones: su localización en fuentes de naturaleza muy variada –protocolos notariales de Granada y Málaga, Registro del Sello de Simancas y Granada, Chancillería de Valladolid, el epistolario del comendador Fuensalida y el archivo privado de la familia Grimaldo de Cáceres– ha permitido seguir su presencia y sus actividades en Granada, la Corte e Inglaterra –donde desempeñó un papel fundamental en el matrimonio entre Catalina de Aragón y Enrique VIII–. Así se conoce su interés por los préstamos y el negocio de la renta, las circunstancias de su matrimonio con Francisca de Cáceres y la adquisición de un importante patrimonio en el reino granadino.

Implementing a structural continuity constraint and a halting method for the topology optimization of energy absorbers

This study investigates topology optimization of energy absorbing structures in which material damage is accounted for in the optimization process. The optimization objective is to design the lightest structures that are able to absorb the required mechanical energy. A structural continuity constraint check is introduced that is able to detect when no feasible load path remains in the finite element model, usually as a result of large scale fracture. This assures that designs do not fail when loaded under the conditions prescribed in the design requirements. This continuity constraint check is automated and requires no intervention from the analyst once the optimization process is initiated. Consequently, the optimization algorithm proceeds towards evolving an energy absorbing structure with the minimum structural mass that is not susceptible to global structural failure. A method is also introduced to determine when the optimization process should halt. The method identifies when the optimization method has plateaued and is no longer likely to provide improved designs if continued for further iterations. This provides the designer with a rational method to determine the necessary time to run the optimization and avoid wasting computational resources on unnecessary iterations. A case study is presented to demonstrate the use of this method.

El patrocinio artístico femenino a través de la monarquía hispánicarchivo de ordenador] : Sancha de León, Isabel La Católica e Isabel de Farnesio

[ES]Análisis del patrocinio artístico ejercido por soberanas españolas de los siglos XI al XVIII. Las reinas elegidas son: Sancha de León (m. 1067) y su legitimación del poder a través de las artes y el tesoro de San Isidoro de León; Isabel de Castilla (1451-1504) y la pintura flamenca: su pintor de cámara Juan de Flandes; e Isabel de Farnesio (1692-1766) y la imposición del arte italiano en el siglo XVIII español con sus colecciones de escultura y pintura.

Experimental viscosity measurements of biodiesels at high pressure

The viscosity of biodiesels of soybean and rapeseed biodiesels blended with mineral diesel fuel were measured at pressures of up to 200 MPa. Using a falling sinker-type viscometer reproducible viscosity data were obtained based on the time taken for a sinker to descend a fixed distance down an enclosed tube under the influence of gravity. Measurements were taken using pressures which correspond to those of interest in automotive common rail diesel engines, and at temperatures of between 25oC and 80oC. In all cases, the viscosity of the biodiesel blends were found to increase exponentially for which the blends were noted as being more viscous than pure mineral fuels. A pressure-freezing effect was not observed for the blends.

Parentalidade em tempos de mudança: articulando tempos de qualidade com tempo livre

Dissertação apresentada à Escola Superior de Educação de Paula Frassinetti para obtenção do grau de Mestre em Educação Pré-escolar

Quantifying aggressive behavior in zebrafish

Aggression is a complex behavior that influences social relationships and can be seen as adaptive or maladaptive depending on the context and intensity of expression. A model organism suitable for genetic dissection of the underlying neural mechanisms of aggressive behavior is still needed. Zebrafish has already proven to be a powerful vertebrate model organism for the study of normal and pathological brain function. Despite the fact that zebrafish is a gregarious species that forms shoals, when allowed to interact in pairs, both males and females express aggressive behavior and establish dominance hierarchies. Here, we describe two protocols that can be used to quantify aggressive behavior in zebrafish, using two different paradigms: (1) staged fights between real opponents and (2) mirror-elicited fights. We also discuss the methodology for the behavior analysis, the expected results for both paradigms, and the advantages and disadvantages of each paradigm in face of the specific goals of the study.

Elaboració de la guia docent de l’assignatura Llengua Catalana aplicada a les Ciències de l’Activitat Física i l’Esport

El propòsit de la xarxa 3252 ha estat el de plantejar una sèrie de canvis en la guia docent de l’assignatura «Llengua Catalana aplicada a les Ciències de l’Activitat Física i l’Esport» (codi 16830), la qual, al nostre parer, acompleix els requisits de llengua d’ús homologable a d’altres d’impartides pel Departament de Filologia Catalana de la UA a la Facultat d’Educació, però no compta amb un inseriment adient en el marc dels estudis del grau que l’acull, ço és, CAFE. En aquest sentit, la memòria present vol ser testimoni dels canvis suggerits en pro d’un encaixament més orgànic i esclaridor d’acord amb una visió fonamentada en el Tractament Integrat de Llengua i Continguts.

Tomus secundus Operum aliquot D. Gregorii Papæ huius nominis primi, cognomento magni, doctæ ac piæ institutionis refertissimorum : nunc denuo ad fidem veterum exemplarium accuratiori diligentia à mendis innumeris repurgatorum ...

Capitulares grab. xil.

VERIFYING SUCCESS OF ARTIFICIAL REEFS IN THE HURON-ERIE CORRIDOR FOR LAKE STURGEON

Lake sturgeon (Acipenser fulvescens) were historically abundant in the Huron-Erie Corridor (HEC), a 160 km river/channel network composed of the St. Clair River, Lake St. Clair, and the Detroit River that connects Lake Huron to Lake Erie. In the HEC, most natural lake sturgeon spawning substrates have been eliminated or degraded as a result of channelization and dredging. To address significant habitat loss in HEC, multi-agency restoration efforts are underway to restore spawning substrate by constructing artificial spawning reefs. The main objective of this study was to conduct post-construction monitoring of lake sturgeon egg deposition and larval emergence near two of these artificial reef projects; Fighting Island Reef in the Detroit River, and Middle Channel Spawning Reef in the lower St. Clair River. We also investigated seasonal and nightly timing of larval emergence, growth, and vertical distribution in the water column at these sites, and an additional site in the St. Clair River where lake sturgeon are known to spawn on a bed of ~100 year old coal clinkers. From 2010-12, we collected viable eggs and larvae at all three sites indicating that these artificial reefs are creating conditions suitable for egg deposition, fertilization, incubation, and larval emergence. The construction methods and materials, and physical site conditions present in HEC artificial reef projects can be used to inform future spawning habitat restoration or enhancement efforts. The results from this study have also identified the likelihood of additional uncharacterized natural spawning sites in the St. Clair River. In addition to the field study, we conducted a laboratory experiment involving actual substrate materials that have been used in artificial reef construction in this system. Although coal clinkers are chemically inert, some trace elements can be reincorporated with the clinker material during the combustion process. Since lake sturgeon eggs and larvae are developing in close proximity to this material, it is important to measure the concentration of potentially toxic trace elements. This study focused on arsenic, which occurs naturally in coal and can be toxic to fishes. Total arsenic concentration was measured in samples taken from four substrate treatments submerged in distilled water; limestone cobble, rinsed limestone cobble, coal clinker, and rinsed coal clinker. Samples were taken at three time intervals: 24 hours, 11 days, and 21 days. ICP-MS analysis showed that concentrations of total arsenic were below the EPA drinking water standard (10 ppb) for all samples. However, at the 24 hour sampling interval, a two way repeated measures ANOVA with a Holm-Sidak post hoc analysis (α= 0.05) showed that the mean arsenic concentration was significantly higher in the coal clinker substrate treatment then in the rinsed coal clinker treatment (p=0.006), the limestone cobble treatment (p

The Role of the Transcription Factor Ets1 in Melanocyte Development

Melanocytes, pigment-producing cells, derive from the neural crest (NC), a population of pluripotent cells that arise from the dorsal aspect of the neural tube during embryogenesis. Many genes required for melanocyte development were identified using mouse pigmentation mutants. The deletion of the transcription factor Ets1 in mice results in hypopigmentation; nevertheless, the function of Ets1 in melanocyte development is unknown. The goal of the present study was to establish the temporal requirement and role of Ets1 in murine melanocyte development. In the mouse, Ets1 is widely expressed in developing organs and tissues, including the NC. In the chick cranial NC, Ets1 is required for the expression of Sox10, a transcription factor critical for the development of melanocytes, enteric ganglia, and other NC derivatives. Using a combination of immunofluorescence and cell survival assays Ets1 was found to be required between embryonic days 10 and 11, when it regulates NC cell and melanocyte precursor (melanoblast) survival. Given the requirement of Ets1 for Sox10 expression in the chick cranial NC, a potential interaction between these genes was investigated. Using genetic crosses, a synergistic genetic interaction between Ets1 and Sox10 in melanocyte development was found. Since Sox10 is essential for enteric ganglia formation, the importance of Ets1 on gut innervation was also examined. In mice, Ets1 deletion led to decreased gut innervation, which was exacerbated by Sox10 heterozygosity. At the molecular level, Ets1 was found to activate a Sox10 enhancer critical for Sox10 expression in melanoblasts. Furthermore, mutating Ets1 at a site I characterized in the spontaneous variable spotting mouse pigmentation mutant, led to a 2-fold decrease in enhancer activation. Overexpression and knockdown of Ets1 did not affect Sox10 expression; nonetheless, Ets1 knockdown led to a 6-fold upregulation of the transcription factor Sox9, a gene required for melanocyte and chondrocyte development, but which impairs melanocyte development when its expression is prolonged. Together, these results suggest that Ets1 is required early during melanocyte development for NC cell and melanoblast survival, possibly acting upstream of Sox10. The transcription factor Ets1 may also act indirectly in melanocyte fate specification by repressing Sox9 expression, and consequently cartilage fate.

Tendencia editorial UR Número 2

El Boletín Tendencia Editorial es un proyecto que nació en 2010 con motivo de la Feria Internacional del Libro de Bogotá para construir y hacer visibles diferentes saberes desde la academia y la edición. Para 2014, el cambio de periodicidad coincidió con uno de los eventos más importantes para la edición universitaria, la Feria Internacional del Libro de Guadalajara donde anualmente se realiza el encuentro de Editores Universitarios Latinoamericanos, el proyecto pasó de su fase nacional a ser pensado en red. Las líneas temáticas traspasan fronteras locales y convocan, en un mismo espacio, las voces de los gestores y especialistas, cuya labor y experiencia permiten cada día mejorar la edición universitaria, lo que posibilita acabar con el mito que concibe a la Universidad como ente ajeno a la sociedad, cuando en realidad esta es la forjadora de líderes, investigadores y emprendedores.

Participación comunitaria y legislación en El Salvador. Análisis de la legislación identificada

Community participation has been considered strategic in order to achieve effectiveness in political, economical, social, educational and cultural change processes as a mean of guarantying effectiveness, quality and sustainability in social policy. Accordingly, this participation must be stimulated and promoted through national legislation since it has traditionally and historically been imposed and undemocratic. Education, as an essentially human act, is a first order instrument that societies must take advantage of in order to develop and stimulate democratic participation. Therefore, education may represent a new culture: one of democratic participation as a fundamental way to empower and develop a Peace culture.

Integral Perspective of the Costa Rican Educational Development

The purpose of this essay is to raise the educational development that has been experienced in our country, outlining influential frames such as political, social, religious and economical ones. It aims to report statistical data as indicators of the development of our educational system, in areas of coverage, average education, repetition, desertion, among others. It is imperative to achieve changes and restructuring in our education system at all levels, from kindergarten to university, so it should take into account the contribution of all stakeholders in the education sector, as the human resource is valuable and all the innovative proposals should be heard, especially those that seek to build together and not ideas imposed that hinder the development of education in our country. Improvements must be necessary because there is an existing desire by many people of improving and achieving a true enrichment in our education.

Avaliação e manejo de casos de constipação

Apresenta a fundamentação teórica sobre a constipação, visando traçar e desenvolver medidas de prevenção e manejo, a fim de serem aplicadas por profissionais que atuam na Atenção Domiciliar. Material da Unidade 2 do Módulo 14 “Intercorrências agudas no domicílio I” do Programa Multicêntrico de Qualificação em Atenção Domiciliar a Distância.