AWI Bathymetric Chart of the Fram Strait (BCFS) (Scale 1:100,000)

Based on data from R/V Polarstern multibeam sonar surveys between 1984 and 1997 a high resolution bathymetry has been generated for the central Fram Strait. The area ensonified covers approx. 36,500 sqkm between 78°N - 80°N and 0°E - 7.5°E. Basic outcome of the investigation is a Digital Terrain Model (DTM) with 100 m grid spacing which was utilized for contouring and generation of a new series of bathymetric charts at a scale of 1:100,000, the AWI Bathymetric Chart of the Fram Strait (AWI BCFS).

Pesticide Food Safety Act of 1988 [microform] : hearings before the Subcommittee on Department Operations, Research, and Foreign Agriculture of the Committee on Agriculture, House of Representatives, One Hundredth Congress, second session, on H.R. 4937, July 28 and September 7, 1988.

"Serial no. 100-99."

Review of U.S. Department of Agriculture's Animal and Plant Health Inspection Service [microform] : hearing before the Subcommittee on Department Operations, Research, and Foreign Agriculture of the Committee on Agriculture, House of Representatives, One Hundredth Congress, second session, July 7, 1988.

"Serial no. 100-97."

Managing hazardous waste and sewage sludge [microform] : hearing before the Subcommittee on Transportation, Tourism, and Hazardous Materials of the Committee on Energy and Commerce, House of Representatives, One Hundredth Congress, first session, December 7, 1987.

"Serial no. 100-163."

Operator's manual : cable assembly, special purpose, electrical, CX-11230/G (1/4 mile) (NSN 5995-00-133-9126), CX-11230/G (100 foot) (NSN 5995-00-133-9127) ....

"7 November 1983."

Organizational maintenance manual : compressor, rotary, air; wheel mounted, pneumatic tires, diesel driven; 600 CFM; 100 psi, (Ingersoll-Rand model DR-600), nonwinterized (FSN 4310-542-2525), winterized to minus 65p0sF (FSN 4310-542-2526).

Includes index.

O GLORIAR-SE EM 2 CORÍNTIOS 12, 7 - 21 Auto-Glorificação ou Defesa da Honra

Esta pesquisa tem como objetivo analisar a utilização do gênero literário do gloriar-se pelo apóstolo Paulo, demonstrando como esta ferramenta foi fundamental para que ele se posicionasse de maneira inovadora e radical frente às acusações sofridas da comunidade cristã em corinto. A comunidade sob a influência de pregadores itinerantes, autointitulados apóstolos, procuraram desonrar o apóstolo em sua ausência. Sendo uma comunidade cristã primitiva no mediterrâneo do I século, o bem mais valioso era a Honra, esta deveria ser defendida acima de tudo. Para tanto, o apóstolo se utiliza do ato de gloriar, como um gênero literário de sua época, bem como de outros recursos da retórica na realização de sua defesa. Ao fazê-lo, o apóstolo resignifica o ato de gloriar, as características de um verdadeiro apóstolo, bem como trata do sofrimento como algo inerente ao fiel seguidor de Cristo. Desta maneira, o apóstolo além de defender-se expõe uma nova proposta no entendimento e vivência nas relações sociais, que deveriam passar pelo ato da renúncia ao status; constituindo uma comunidade igualitária.

Studies on the neurotoxicity of 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) in SH-SY5Y cells

We have studied the hypothesis that 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) is neurotoxic. Salsolinol induced a significant time and dose related inhibition of 3[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; thiazoyl blue (MTT) reduction, and increased lactate dehydrogenase release (LDH) release from human SH-SY5Y neuroblastoma cells, at concentrations within the range of 1-methyl-4-phenylpyridinium (MPP+) cytotoxicity, in vitro. Cytotoxicity was not inhibited by the addition of antioxidants, monoamine oxidase inhibitors or imipramine. In confluent monolayers, salsolinol stimulated catecholamine uptake with EC50 values of 17 muM and 11 muM, for noradrenaline and dopamine, respectively. Conversely, at concentrations above 100 muM, salsolinol inhibited the uptake of noradrenaline and dopamine, with IC50 values of 411 muM and 379 muM, respectively. The inhibition of catecholamine uptake corresponded to the increase displacement of [3H]nisoxetine from the uptake 1 site by salsolinol, as the Ki (353 muM) for displacement was similar to the IC50 (411 and 379 muM) for uptake. Salsolinol stimulated catecholamine uptake does not involve the uptake recognition site, or elevation of cAMP, cGMP, or inhibition of protein kinase C. Salsolinol also inhibited both carbachol (1 mM) and K+ (100 mM, Na+ adjusted) evoked released of noradrenaline from SH-SY5Y cells, with IC50 values of 500 muM and 120 muM, respectively. In conclusion, salsolinol appears to be cytotoxic to SH-SY5Y cells, via a mechanism that does not require uptake 1, bioactivation by monoamine oxidase, or membrane based free radical damage. The effects of salsolinol on catecholamine uptake, and the mechanism of toxicity require further investigation.