Anthropogenic aerosol emissions and rainfall decline in South-West Australia - accompanying model results in NetCDF format

It is commonly understood that the observed decline in precipitation in South-West Australia during the 20th century is caused by anthropogenic factors. Candidates therefore are changes to large-scale atmospheric circulations due to global warming, extensive deforestation and anthropogenic aerosol emissions - all of which are effective on different spatial and temporal scales. This contribution focusses on the role of rapidly rising aerosol emissions from anthropogenic sources in South-West Australia around 1970. An analysis of historical longterm rainfall data of the Bureau of Meteorology shows that South-West Australia as a whole experienced a gradual decline in precipitation over the 20th century. However, on smaller scales and for the particular example of the Perth catchment area, a sudden drop in precipitation around 1970 is apparent. Modelling experiments at a convection-resolving resolution of 3.3km using the Weather and Research Forecasting (WRF) model version 3.6.1 with the aerosol-aware Thompson-Eidhammer microphysics scheme are conducted for the period 1970-1974. A comparison of four runs with different prescribed aerosol emissions and without aerosol effects demonstrates that tripling the pre-1960s atmospheric CCN and IN concentrations can suppress precipitation by 2-9%, depending on the area and the season. This suggests that a combination of all three processes is required to account for the gradual decline in rainfall seen for greater South-West Australia and for the sudden drop observed in areas along the West Coast in the 1970s: changing atmospheric circulations, deforestation and anthropogenic aerosol emissions.

FESOM Arctic Ocean sea ice concentration and thickness 1995-2014, links to movies in mp4 format

Northern Hemisphere sea ice from a Finite-Element Sea-Ice Ocean Model (FESOM) 4.5 km resolution simulation carried out by researchers from Alfred Wegener Institute (AWI), Germany. Concentration is shown with color; thickness is shown with shading. A global 1 degree mesh is used, with the "Arctic Ocean" locally refined to 4.5 km. South of CAA and Fram Strait the resolution is not refined in this simulation. The animation indicates that the 4.5 km model resolution helps to represent the small scale sea ice features, although much higher resolution is required to fully resolve the ice leads. The animation is created by Michael Böttinger from DKRZ (https://www.dkrz.de).

PanConverter - a tool for data conversion and recalculation, written to convert special data collections to standard import format used by PANGAEA

Supported file formats: - CrossRef XML file(s) - TRiDaS (Tree Ring Data Standard, http://www.tridas.org). Example: hdl:10013/epic.42747.d001 - IMMA (International Maritime Meteorological Archive). Used by the project CLIWOC (García-Herrera et al. 2007, http://doi.pangaea.de/10.1594/PANGAEA.743343) - NOAA IOAS (International Ocean Atlas Series). Example: hdl:10013/epic.42747.d008 - SOCAT (Surface Ocean CO2 Atlas, Bakker et al. 2014, http://doi.pangaea.de/10.1594/PANGAEA.811776) - CHUAN (Comprehensive Historical Upper-Air Network, Stickler et al. 2013, http://doi.pangaea.de/10.1594/PANGAEA.821222). Example: hdl:10013/epic.42747.d003 - Thermosalinograph (TSG) data. Format developed by Gerd Rohardt. Example: hdl:10013/epic.42747.d002 - Columus GPS Data Logger V-900 format to KML or GPX. Example: hdl:10013/epic.42747.d006

3-dimensional binaural sound rendering using acoustic measurements stored in the SOFA format

Several groups all over the world are researching in several ways to render 3D sounds. One way to achieve this is to use Head Related Transfer Functions (HRTFs). These measurements contain the Frequency Response of the human head and torso for each angle. Some years ago, was only possible to measure these Frequency Responses only in the horizontal plane. Nowadays, several improvements have made possible to measure and use 3D data for this purpose. The problem was that the groups didn't have a standard format file to store the data. That was a problem when a third part wanted to use some different HRTFs for 3D audio rendering. Every of them have different ways to store the data. The Spatially Oriented Format for Acoustics or SOFA was created to provide a solution to this problem. It is a format definition to unify all the previous different ways of storing any kind of acoustics data. At the moment of this project they have defined some basis for the format and some recommendations to store HRTFs. It is actually under development, so several changes could come. The SOFA[1] file format uses a numeric container called netCDF[2], specifically the Enhaced data model described in netCDF 4 that is based on HDF5[3]. The SoundScape Renderer (SSR) is a tool for real-time spatial audio reproduction providing a variety of rendering algorithms. The SSR was developed at the Quality and Usability Lab at TU Berlin and is now further developed at the Institut für Nachrichtentechnik at Universität Rostock [4]. This project is intended to be an introduction to the use of SOFA files, providing a C++ API to manipulate them and adapt the binaural renderer of the SSR for working with the SOFA format. RESUMEN. El SSR (SoundScape Renderer) es un programa que está siendo desarrollado actualmente por la Universität Rostock, y previamente por la Technische Universität Berlin. El SSR es una herramienta diseñada para la reproducción y renderización de audio 2D en tiempo real. Para ello utiliza diversos algoritmos, algunos orientados a sistemas formados por arrays de altavoces en diferentes configuraciones y otros algoritmos diseñados para cascos. El principal objetivo de este proyecto es dotar al SSR de la capacidad de renderizar sonidos binaurales en 3D. Este proyecto está centrado en el binaural renderer del SSR. Este algoritmo se basa en el uso de HRTFs (Head Related Transfer Function). Las HRTFs representan la función de transferencia del sistema formado por la cabeza y el torso del oyente. Esta función es medida desde diferentes ángulos. Con estos datos el binaural renderer puede generar audio en tiempo real simulando la posición de diferentes fuentes. Para poder incluir una base de datos con HRTFs en 3D se ha hecho uso del nuevo formato SOFA (Spatially Oriented Format for Acoustics). Este nuevo formato se encuentra en una fase bastante temprana de su desarrollo. Está pensado para servir como formato estándar para almacenar HRTFs y cualquier otro tipo de medidas acústicas, ya que actualmente cada laboratorio cuenta con su propio formato de almacenamiento y esto hace bastante difícil usar varias bases de datos diferentes en un mismo proyecto. El formato SOFA hace uso del contenedor numérico netCDF, que a su vez esta basado en un contenedor más básico llamado HRTF-5. Para poder incluir el formato SOFA en el binaural renderer del SSR se ha desarrollado una API en C++ para poder crear y leer archivos SOFA con el fin de utilizar los datos contenidos en ellos dentro del SSR.

Efficient RDF Interchange (ERI) format for RDF data streams

RDF streams are sequences of timestamped RDF statements or graphs, which can be generated by several types of data sources (sensors, social networks, etc.). They may provide data at high volumes and rates, and be consumed by applications that require real-time responses. Hence it is important to publish and interchange them efficiently. In this paper, we exploit a key feature of RDF data streams, which is the regularity of their structure and data values, proposing a compressed, efficient RDF interchange (ERI) format, which can reduce the amount of data transmitted when processing RDF streams. Our experimental evaluation shows that our format produces state-of-the-art streaming compression, remaining efficient in performance.

Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: A unique signaling pathway in the steroid receptor superfamily

The androgen receptor (AR) binds to androgen response elements and regulates target genes via a mechanism involving coregulators. Here we demonstrate that the AR can interact with the testicular orphan receptor-4 (TR4) and function as a repressor to down-regulate the TR4 target genes by preventing the TR4 binding to its target DNA. Interestingly, the heterodimerization of AR and TR4 also allows TR4 to repress AR target gene expression. Simultaneous exposure to both receptors therefore could result in bidirectional suppression of their target genes. Together, these data demonstrate that the coupling of two different receptors, through the heterodimerization of AR and TR4, is a unique signaling pathway in the steroid receptor superfamily, which may facilitate further understanding of the complicated androgen action in prostate cancer or libido.

Making artificial antibodies: A format for phage display of combinatorial heterodimeric arrays

The gene VII protein (pVII) and gene IX protein (pIX) are associated closely on the surface of filamentous bacteriophage that is opposite of the end harboring the widely exploited pIII protein. We developed a phagemid format wherein antibody heavy- and light-chain variable regions were fused to the amino termini of pVII and pIX, respectively. Significantly, the fusion proteins interacted to form a functional Fv-binding domain on the phage surface. Our approach will be applicable to the display of generic peptide and protein libraries that can form combinatorial heterodimeric arrays. Consequently, it represents a first step toward artificial antibodies and the selection of novel biological activities.

p53-dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells

Testicular cancers respond favorably to chemotherapy with the platinum-containing drug cis-diamminedichloroplatinum(II) (cisplatin). One factor that could explain the efficacy of cisplatin is the low frequency of p53 mutations observed in this tumor type. The present study examines the p53-mediated responses in murine testicular teratocarcinoma cells exposed to the drug. Cisplatin treatment of teratocarcinoma cells with a wild-type p53 gene resulted in accumulation of the p53 protein through posttranscriptional mechanisms; induction of p53-target genes was also observed. Drug treatment resulted in rapid apoptosis in p53-wild-type cells but not in p53−/− teratocarcinoma cells. In the latter cells, cisplatin exposure caused prolonged cell cycle arrest accompanied by induction of the p21 gene. Clonogenic assays demonstrated that the p53 mutation did not confer resistance to cisplatin. These experiments suggest that cisplatin inhibits cellular proliferation of testicular teratocarcinoma cells by two possible mechanisms, p53-dependent apoptosis and p53-independent cell cycle arrest.