Cálculo de la atracción gravimétrica inducida por el Pabellón de Gravimetría del Centro de Desarrollos Tecnológicos de Yebes (Instituto Geográfico Nacional).

En el presente Trabajo Fin de Grado se modeliza la estructura del Pabellón de Gravimetría del Centro Astronómico de Yebes para así poder determinar su influencia sobre los valores de gravedad observados en el interior del Pabellón. El Pabellón de Gravimetría dispone en su interior de una sala dónde se realizan medidas de gravedad sobre siete pilares de hormigón situados a nivel del suelo. Para poder modelizar la sala de medida se ha realizado un levantamiento topográfico con las especificaciones técnicas de una escala 1:100. Tras la realización del levantamiento se han determinado las coordenadas geográficas del centro de los pilares de medida mediante el cálculo de una radiación, pues es necesario conocer éste dato al realizar medidas relativas de gravedad. Para el cálculo de la influencia que genera la estructura del Pabellón sobre las medidas de gravedad observadas en su interior se han creado una serie de programas en lenguaje Java empleando la fórmula de la atracción gravitatoria que genera un prisma (Nagy, 1969). Una vez se han llevado a cabo las observaciones y los cálculos necesarios se concluye que la influencia de la estructura sobre las medidas de la gravedad observadas en el interior del Pabellón no es de gran magnitud. No obstante esnecesario conocerla y así poder corregir los valores observados. Asimismo, se determina cierta desorientación de los pilares de medida con respecto al norte geográfico. El presente Trabajo Fin de Grado permitirá, entre otros, que el Centro de Desarrollos Tecnológicos de Yebes participe en proyectos de carácter internacional. Abstract: In the current Bachelor Thesis, the structure of the Pavellón de Gravimetría del Centro Astronómico de Yebes is moulded in order to determine its influence on the observed values of gravity inside the Pavilion. The Pabellón de Gravimetría holds in its interior a room where gravity measures are made on seven concrete pillars located on the ground level. In order to be able to mould the room, a topographical survey measurement was made on a 1:100 scale. After concluding the topographical survey measurement the geographical coordinates of the centre of the measurement pillars were determined, due to the necessity to know this data when making relative gravity measures. To calculate the influence that the pavilion structure has on the observed gravity measures in its interior generates, a series of programs in Java language have been created using the formula of the gravitational attraction that generates a prism (Nagy, 1969). Once the observations and the necessary calculations have been carried out, it is concluded that the influences of the structure of the Pavilion on the observed gravity measures inside it are not of a considerable magnitude. Despite that, it is necessary to know this to be able to correct the observed values. Also, certain disorientations of the pillars of measurement with respect to the geographical north is determined. The current Bachelor Thesis will allow, among others, the Centre of Technological Developments of Yebes to get involved in projects of international nature.

Occurrence of moulds associated with ovine raw milk and cheeses of the Spanish region of Castilla La Mancha

The distribution of mould species was examined at several points of the processing chain in a Manchego cheese plant and associated dairy farms. Geotrichum and Fusarium were the most frequent genera isolated in milk samples as well as in 1-month ripened cheeses, evidencing a direct transfer from raw milk. Conversely, the mycobiota of long-ripened cheeses consisted mainly of Penicillium species, which gained entry to the cheese through the air of ripening rooms. This study contributes to the understanding of the dynamics of fungal populations in semihard and hard cheeses, highlighting that airborne transfer from the stables could have a direct impact on their quality.

Influência da substituição de matérias primas nas propriedades dos fluxantes para lingotamento contínuo de aços médio carbono

O fluxante é uma escória sintética que influencia na qualidade superficial do aço e na estabilidade do processo de lingotamento contínuo. Este produto é aplicado diretamente sobre o aço líquido na região do molde de cobre refrigerado a água e atua diretamente no resfriamento primário do aço. O fluxante tem as propriedades físico-químicas adaptadas para cada tipo de aço e também para as condições de lingotamento. Na superfície do aço líquido, o fluxante funde e forma uma poça líquida, atuando como isolante térmico, protegendo o aço da reoxidação e absorvendo inclusões principalmente de Al2O3. A poça líquida escoa, lubrificando e controlando a transferência de calor na interface entre o molde e a pele de aço em solidificação. O problema de qualidade superficial do aço, quando relacionado ao fluxante, se resume a alarmes de colamento, trincas de quina, marcas de oscilação profundas e trincas longitudinais, sendo este último um problema particular do aço médio carbono. Neste trabalho, foram analisados diferentes fluxantes baseados inicialmente no fluxante comercial aplicado no lingotamento contínuo de placas de aço médio carbono. Todos os fluxantes foram desenvolvidos com composições químicas similares. O objetivo foi avaliar o impacto da substituição de fontes de matérias-primas em diferentes composições de modo a avaliar as propriedades físico-químicas com base no fluxante comercial de referência. Como resultado, de todas as propriedades físico-químicas, foi a temperatura de cristalização que sofreu a alteração mais significativa.

What can physical, biotic and chemical features of a tree hollow tell us about their associated diversity?

Tree hollows are keystone structures for saproxylic fauna and host numerous endangered species. However, not all tree hollows are equal. Many variables including physical, biotic and chemical ones, can characterise a tree hollow, however, the information that these could provide about the saproxylic diversity they harbour has been poorly explored. We studied the beetle assemblages of 111 Quercus species tree hollows in four protected areas of the Iberian Peninsula. Three physical variables related to tree hollow structure, and two biotic ones (presence of Cetoniidae and Cerambyx species recognised as ecosystem engineers) were measured in each hollow to explore their relative effect on beetle assemblages. Moreover, we analysed the chemical composition of the wood mould in 34 of the hollows, in order to relate beetle diversity with hollow quality. All the environmental variables analysed (physical and biological) showed a significant influence on saproxylic beetle assemblages that varied depending on the species. Furthermore, the presence of ecosystem engineers affected both physical and chemical features. Although wood mould volume, and both biotic variables could act as beetle diversity surrogate, we enhance the presence of Cetoniidae and Cerambyx activity (both easily observable in the field) as indicator variables, even more if both co-occur as each affect to different assemblages. Finally, assimilable carbon and phosphorous contents could act as indicator for past and present beetle activity inside the cavity that could become a useful tool in functional diversity studies. However, an extension of this work to other taxonomic groups would be desirable.

Russia’s Middle East policy after the Arab revolutions. OSW Commentary No. 59, 2011-07-26

Russia’s policy towards the Middle East is instrumental. Its activity in the region has been growing since the middle of the last decade, and its aim is to help Moscow achieve its objectives in other areas, particularly in its policies towards the US and Europe, as well as its energy policy. The establishment of these political influences constitutes a bargaining chip for Russia in its relations with the US. Russia’s participation in resolving conflicts is aimed at building up its image as a supra-regional power. Russia’s Middle East policy is a key element in its contacts with the Muslim world. At the same time, Russia’s policy in the region remains cautious – despite its return to the region, Russia has not decided to ‘play’ for the Middle East, and its position and role in the region remain limited. The balance of power in the Middle East has been shifting in the aftermath of the Arab revolutions. However, it does not seem that they have opened up larger opportunities for Russian policy in the region. The Russian elite has been divided in its assessment of the consequences of these events. One part of it has displayed scepticism, treating the revolutions rather as a threat than a chance to strengthen their own position. The revolutions were not seen as democratisation processes, but rather as a destabilisation of the region and as posing an increased danger from radical Islam. For the other part of the elite, the revolutions were the natural consequence of the social changes occurring in the region. This internal dispute made it difficult for Russia to present a cohesive approach to the Arab revolutions, and its stance was reactive. The defensive position which Moscow adopted showed that Russia did not have the potential to mould the political situation, either in the region as a whole or its individual countries; neither did it display any willingness to do so. What Moscow is doing is positioning itself in such a way so as not to spoil relations with any other actor in the region, and to be able to exploit any possible emerging opportunities in case of further-reaching changes.

Rule-Makers or Rule-Takers? Exploring the Transatlantic Trade and Investment Partnership

The Transatlantic Trade and Investment Partnership (TTIP) is an effort by the United States and the European Union to reposition themselves for a world of diffuse economic power and intensified global competition. It is a next-generation economic negotiation that breaks the mould of traditional trade agreements. At the heart of the ongoing talks is the question whether and in which areas the two major democratic actors in the global economy can address costly frictions generated by their deep commercial integration by aligning rules and other instruments. The aim is to reduce duplication in various ways in areas where levels of regulatory protection are equivalent as well as to foster wide-ranging regulatory cooperation and set a benchmark for high-quality global norms. In this volume, European and American experts explain the economic context of TTIP and its geopolitical implications, and then explore the challenges and consequences of US-EU negotiations across numerous sensitive areas, ranging from food safety and public procurement to economic and regulatory assessments of technical barriers to trade, automotive, chemicals, energy, services, investor-state dispute settlement mechanisms and regulatory cooperation. Their insights cut through the confusion and tremendous public controversies now swirling around TTIP, and help decision-makers understand how the United States and the European Union can remain rule-makers rather than rule-takers in a globalising world in which their relative influence is waning.

Lichtheimia Infection in a Lymphoma Patient: Case Report and a Brief Review of the Available Diagnostic Tools

We describe the case of a patient with a T-lymphoblastic lymphoma whose disseminated mucormycosis was diagnosed with delay, and we address the diagnostic and therapeutic decision-making process and review the diagnostic workup of patients with potential IFD. The diagnosis was delayed despite a suggestive radiological presentation of the patient's pulmonary lesion. The uncommon risk profile (T-lymphoblastic lymphoma, short neutropenic phases) wrongly led to a low level of suspicion. The diagnosis was also hampered by the lack of indirect markers for infections caused by Mucorales, the low sensitivity of both fungal culture and panfungal PCR, and the limited availability of species-specific PCR. A high level of suspicion of IFD is needed, and aggressive diagnostic procedures should be promptly initiated even in apparently low-risk patients with uncommon presentations. The extent of the analytical workup should be decided on a case-by-case base. Diagnostic tests such as the galactomannan and β-D-glucan test and/or PCR on biological material followed by sequencing should be chosen according to their availability and after evaluation of their specificity and sensitivity. In high-risk patients, preemptive therapy with a broad-spectrum mould-active antifungal agent should be started before definitive diagnostic findings become available.

Direct electrospinning of 3D auricle-shaped scaffolds for tissue engineering applications.

Thirty-two poly(ε)caprolactone (PCL) scaffolds have been produced by electrospinning directly into an auricle-shaped mould and seeded with articular chondrocytes harvested from bovine ankle joints. After seeding, the auricle shaped constructs were cultured in vitro and analysed at days 1, 7, 14 and 21 for regional differences in total DNA, glycosaminoglycan (GAG) and collagen (COL) content as well as the expression of aggrecan (AGG), collagen type I and type II (COL1/2) and matrix metalloproteinase 3 and 13 (MMP3/13). Stress-relaxation indentation testing was performed to investigate regional mechanical properties of the electrospun constructs. Electrospinning into a conductive mould yielded stable 3D constructs both initially and for the whole in vitro culture period, with an equilibrium modulus in the MPa range. Rapid cell proliferation and COL accumulation was observed until week 3. Quantitative real time PCR analysis showed an initial increase in AGG, no change in COL2, a persistent increase in COL1, and only a slight decrease initially for MMP3. Electrospinning of fibrous scaffolds directly into an auricle-shape represents a promising option for auricular tissue engineering, as it can reduce the steps needed to achieve an implantable structure.

Tracts on the natural history of animals and vegetables,

I. Physiological reflections on the natureal history of animals and vegetables. Observations and experiments upon the animalcula of infusions. Two epistolary dissertations on infusion animacula addressed to the author, by M. Bonnet of Geneva. Observations and experiments on the seminal vermiculi of man and other animals, with an examination of the celebrated theory of organic molecules.--II. Observations and experiments on the seminal vermiculi [cont'd] Observations and experiments on some singular animals which may be killed and revised. Observations and experiments on the origin of the plantulae of mould. Results of experiments on the reproduction of the head of the garden snail. Experiments on the reproduction of the head of the terrestrial snail, by C. Bonnet. Memoirs on the reproduction of the members of the water newt, by C. Bonnet.

Pre-reformation churches in Fifeshire /

Cathedrals and abbey churches not included.

Melrose and its vicinity.

Mode of access: Internet.

The 1000 brightest hipass galaxies: The H I mass function and Omega(H I)

We present a new, accurate measurement of the H I mass function of galaxies from the HIPASS Bright Galaxy Catalog, a sample of 1000 galaxies with the highest H I peak flux densities in the southern (delta

The 1000 brightest HIPASS galaxies H I properties

We present the HIPASS Bright Galaxy Catalog (BGC), which contains the 1000 H I brightest galaxies in the southern sky as obtained from the H i Parkes All-Sky Survey ( HIPASS). The selection of the brightest sources is based on their H I peak flux density (S-peak greater than or similar to116 mJy) as measured from the spatially integrated HIPASS spectrum. The derived H I masses range from similar to10(7) to 4 x 10(10) M-.. While the BGC ( z< 0.03) is complete in S-peak, only a subset of &SIM;500 sources can be considered complete in integrated H I flux density (F-H I &GSIM;25 Jy km s(-1)). The HIPASS BGC contains a total of 158 new redshifts. These belong to 91 new sources for which no optical or infrared counterparts have previously been cataloged, an additional 51 galaxies for which no redshifts were previously known, and 16 galaxies for which the cataloged optical velocities disagree. Of the 91 newly cataloged BGC sources, only four are definite H I clouds: while three are likely Magellanic debris with velocities around 400 km s(-1), one is a tidal cloud associated with the NGC 2442 galaxy group. The remaining 87 new BGC sources, the majority of which lie in the zone of avoidance, appear to be galaxies. We identified optical counterparts to all but one of the 30 new galaxies at Galactic latitudes > 10degrees. Therefore, the BGC yields no evidence for a population of free-floating'' intergalactic H I clouds without associated optical counterparts. HIPASS provides a clear view of the local large-scale structure. The dominant features in the sky distribution of the BGC are the Supergalactic Plane and the Local Void. In addition, one can clearly see the Centaurus Wall, which connects via the Hydra and Antlia Clusters to the Puppis Filament. Some previously hardly noticable galaxy groups stand out quite distinctly in the H I sky distribution. Several new structures, including some not behind the Milky Way, are seen for the first time.

The alpha(2)delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Ca(v)2.2) calcium channels

The omega-conotoxins from fish-hunting cone snails are potent inhibitors of voltage-gated calcium channels. The omega-conotoxins MVIIA and CVID are selective N-type calcium channel inhibitors with potential in the treatment of chronic pain. The beta and alpha(2)delta-1 auxiliary subunits influence the expression and characteristics of the alpha(1B) subunit of N-type channels and are differentially regulated in disease states, including pain. In this study, we examined the influence of these auxiliary subunits on the ability of the omega-conotoxins GVIA, MVIIA, CVID and analogues to inhibit peripheral and central forms of the rat N-type channels. Although the beta3 subunit had little influence on the on- and off-rates of omega-conotoxins, coexpression of alpha(2)delta with alpha(1B) significantly reduced on- rates and equilibrium inhibition at both the central and peripheral isoforms of the N-type channels. The alpha(2)delta also enhanced the selectivity of MVIIA, but not CVID, for the central isoform. Similar but less pronounced trends were also observed for N-type channels expressed in human embryonic kidney cells. The influence of alpha(2)delta was not affected by oocyte deglycosylation. The extent of recovery from the omega-conotoxin block was least for GVIA, intermediate for MVIIA, and almost complete for CVID. Application of a hyperpolarizing holding potential ( - 120 mV) did not significantly enhance the extent of CVID recovery. Interestingly, [R10K] MVIIA and [O10K] GVIA had greater recovery from the block, whereas [K10R] CVID had reduced recovery from the block, indicating that position 10 had an important influence on the extent of omega-conotoxin reversibility. Recovery from CVID block was reduced in the presence of alpha(2)delta in human embryonic kidney cells and in oocytes expressing alpha(1B-b). These results may have implications for the antinociceptive properties of omega-conotoxins, given that the alpha(2)delta subunit is up-regulated in certain pain states.

A preform design method for sheet superplastic bulging with finite element modeling

Superplastic bulging is the most successful application of superplastic forming (SPF) in industry, but the non-uniform wall thickness distribution of parts formed by it is a common technical problem yet to be overcome. Based on a rigid-viscoplastic finite element program developed by the authors, for simulation of the sheet superplastic forming process combined with the prediction of microstructure variations (such as grain growth and cavity growth), a simple and efficient preform design method is proposed and applied to the design of preform mould for manufacturing parts with uniform wall thickness. Examples of formed parts are presented here to demonstrate that the technology can be used to improve the uniformity of wall thickness to meet practical requirements. (C) 2004 Elsevier B.V. All rights reserved.