Pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia

Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives.

A Qualidade da Interação Positiva e da Consistência Parental na sua Relação com Problemas de Comportamentos de Pré-Escolares

Studies have shown a relationship to exist between behavior problems in children and quality of parental practices such as communication, expressivity, consistency, and monitoring. This study aimed at describing relationships that parents have with their preschool children, and also at relating parenting skills to child behavior. We compared fathers' and mothers' social educational skills in two groups of children, with or without behavior problems at school. Research was conducted in a town in the State of Sao Paulo, BR. Participants were biological mothers and fathers of 48 preschoolers; twenty-five children presented behavior problems at school, and 24 had high social skills. Parents were individually interviewed at home. Results showed that fathers and mothers of socially skilled children were more consistent in their practices. They were more able to identify and describe their children's socially skilled behaviors. They also reported they gave more positive feedbak for their children's good behavior.

Interação entre grau de perda auditiva e o incômodo com zumbidos em trabalhadores com história de exposição ao ruído

Hearing loss and tinnitus impact the lives of workers in every instance of their lives. Aim: this paper aims to investigate the existence of a dose-response relationship between hearing loss and tinnitus by determining whether higher levels of hearing loss can be associated with increased tinnitus-related discomfort. Materials and method: this cross-sectional case study assessed 284 workers exposed to occupational noise through pure tone audiometry. Test results were categorized as defined by Merluzzi. Individuals complaining of tinnitus answered the adapted and validated Brazilian Portuguese version of the Tinnitus Handicap Inventory. A generalized linear model was adjusted for binomial data to test the interaction between these factors. Results: over 60% of the ears analyzed had hearing loss, while more than 46% of them had tinnitus. Tinnitus prevalence and risk rates increased as pure tone audiometry results got worse. The association between both, considering all hearing loss degrees, was statistically significant. Conclusion: the results point to a statistical association between hearing loss and tinnitus; the greater the hearing loss, the greater the discomfort introduced by tinnitus. 2009 © Revista Brasileira de Otorrinolaringologia.

Variação genética, interação genótipo solo e ganhos na seleção em teste de progěnies de Corymbia citriodora Hook em Luiz Antonio, São Paulo

The aim of this study was to investigate the genetic variation, the genotype × soil interaction and the selection among and within Corymbia citriodora progenies in three different kinds of soils (Red Latossol, Quartz Sand and Purple Latossol), which occur in the Luiz Antônio Experimental Station, São Paulo State, Brazil. The progeny test was established 1983, using 56 open-pollinated families of C. citriodora. Twenty fve years after planting the following traits were measured: height, diameter at breast height (Dbh), stem form and survival. Best growth occurred in Purple Latossol. Significant differences among progenies were detected for most traits in all sites, suggesting the possibility of improvement by selection. In the analysis with sites, Significant differences among locals, progenies and genotypes × soil interaction were detected, confiming that the tested material has sufficient genetic variation to be explored by selection in all sites. The analysis of genotype × soil interaction indicates that growth traits present single interaction and the same progenies can be selected in each site. On the order hand, genotype × soil interaction for stem form and survival was complex; and specifc progenies need to be selected for each kind of soil. The population, due to its high genetic variation and strong genetic control of traits, permits to obtain considerable genetic gains by selection among and within progenies.

Interação de um aluno com paralisia cerebral com colegas de classe durante atividades ludicas

The study aimed to examine the quality of interpersonal relationships developed between a child with cerebral palsy (CP) and his classmates during group play activities carried out in the classroom and during recess. The participants of the study were a boy with clinical diagnosis of quadriplegic CP, his teacher and classmates. Data collection was carried out by means of a structured interview with the teacher and of video recording the child with CP interacting with his classmates in play activities. The interview data analysis was carried out using qualitative procedures and the video recording was analyzed using a category system. The results showed that the teacher perceived the child with CP to be interested; he participated in play activities and interacted successfully both with familiar partners and with all classmates in general. On the other hand, the analysis of the video recorded activities showed that even though interaction did in fact occur positively, the child with CP remained mostly an observer of the activities rather than an active participant, possibly due to the gap between the child's possibilities and the requirements imposed by the activities underway in the school setting.

Interação de doses de calcário e zinco na mamoneira

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Interação patógeno-hospedeiro no patossistema capim limão-ferrugem das folhas e avaliação de ingredientes ativos naturais no controle da doença

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A interação professor-aluno nas atividades de escrita: um estudo em salas de primeiro ano do ensino fundamental

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Expressão gênica das adesinas e fatores de virulência da fase miceliar e leveduriforme do complexo paracoccidioides e de sua interação com células epiteliais e fagócitos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Avaliação da capacidade antioxidante de extratos vegetais de plantas brasileiras e sua contribuição ao estudo de inibição da enzima mieloperoxidase

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O fazer e o aprender: uma interação singular na produção de mobiliário artístico da Escola de Artes e Ofícios de Amparo

Pós-graduação em Artes - IA

Atividade da enzima conversora de angiotensina e os níveis plasmáticos de peptídeos do sistema renina-angiotensina (Ang I, Ang II e Ang-(1-7)) em mulheres normotensas e hipertensas no climatério

Pós-graduação em Ciências da Motricidade - IBRC

Estudo da interação entre flavonóides e a albumina do soro humano

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estudos dos efeitos de carga e da hidrofobicidade na interação de peptídeos antimicrobianos e membranas modelo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)