951 resultados para educational hypermedia system N B R 6023 _ references
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This layer is a georeferenced raster image of the historic paper map entitled: Antwerp = (Antwerpen) (Anvers), drawn by W. B. Clarke ; engraved & printed by B. R. Davies. It was published under the Superintendance of the Society for the Diffusion of Useful Knowledge [by] George Cox, Jan. 1, 1852. Scale [ca. 1:4,700]. Covers Antwerp, Belgium.The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'Belge Lambert 1972' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map.This map shows features such as roads, railroads, drainage, canals, built-up areas and selected buildings, fortification, ground cover, and more. Relief shown by hachures. Includes inset map: Plan of the Scheldt & the Forts from Antwerp to Lillo, and views: Antwerp from the road to Mechlin Brussels and Louvain (from a print at the British Museum) and A Comparison of the Principal Buildings at Antwerp.This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.
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This layer is a georeferenced raster image of the historic paper map entitled: Brussels = (Bruxelles), drawn by W.B. Clarke, archt. ; engraved by B.R. Davies. It was published under the superintendence of the Society for the Diffussion of Useful Knowledge [by] George Cox, Jany. 1st, 1853. Scale [ca. 1:120,000]. Covers Brussels, Belgium.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Belgian Lambert 1972 coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map.This map shows features such as roads, drainage, built-up areas and selected buildings, fortification, parks, and more. Includes illustrations of selected buildings and inset: Environs of Brussels. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.
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This layer is a georeferenced raster image of the historic paper map entitled: Geneva = (Genève), engraved by B.R. Davies. It was published by Charles Knight & Co. in 1850. Scale [ca. 1:3,600]. Covers Geneva, Switzerland. Map in English and French. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'CH1903_LV03' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, built-up areas and selected buildings, fortification, ground cover, and more. Includes inset: Environs of Geneva, and view: View of Geneva. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.
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This layer is a georeferenced raster image of the historic paper map entitled: Hamburg, drawn under the direction of Willm. Lindley, Esqr. C.E. April 1841; engraved by B.R. Davies. It was published by George Cox, Jan. 1, 1853. Scale [ca. 1:10,000]. Covers Hamburg, Germany. The image inside the map neatline is georeferenced to the surface of the earth and fit to the WGS84 UTM Zone 32N coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads and stations, drainage, built-up areas and selected buildings, docks, ground cover, and more. Relief is shown by hachures. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.
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This layer is a georeferenced raster image of the historic paper map entitled: The Environs of Edinburgh, B.R. Davies, sculp[t]. It was published by George Cox in Jan[y] 1st, 1853. Scale [ca. 1:85,000]. Covers Edinburgh region, Scotland, United Kingdom.The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'British National Grid' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map.This map shows features such as roads, railroads, drainage, built-up areas and selected buildings, administrative boundaries, ground cover, and more. Relief shown by hachures.This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.
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This layer is a georeferenced raster image of the historic paper map entitled: [Moscow = Moskvi], drawn by W. B. Clarke, Archt., engraved by B. R. Davies. It was published under the superintendence of the Society for the Diffusion of Useful Knowledge [by] Charles Knight & Co. in 1836. Scale [ca. 1:33,000]. Covers Moscow, Russia. Map in English and Russian (including romanized Russian). The image inside the map neatline is georeferenced to the surface of the earth and fit to the European Datum 1950, Universal Transverse Mercator (UTM) Zone 37N projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map.This map shows features such as roads, drainage, built-up areas and selected buildings, bridges, ground cover, fortification, and more. Includes illustrations.This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.
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This layer is a georeferenced raster image of the historic paper map entitled: [St. Petersburg = Sanktpeterburga], published under the superintendance of the Society for the Diffusion of Useful Knowledge ; drawn by W.B. Clarke ; engraved by B.R. Davies. It was published by Edward Stanford ca. 1860. Scale [ca. 1:31,000]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'Pulkovo 1995 Gauss Kruger Zone 6N' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas and selected buildings, ground cover, and more. Includes index and inset view: Isakiefskoi Bridge. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.
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This layer is a georeferenced raster image of the historic paper map entitled: Constantinople = Stambol, engraved by B.R. Davies ; Hellert. It was published by Geoge Cox for the Society for the Diffusion of Useful Knowledge, Jany. 1st, 1853. Scale [ca. 1:22,500,000]. Covers Istanbul, Turkey. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'European Datum 1950 UTM Zone 35N' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map.This map shows features such as roads, drainage, built-up areas and selected buildings (mosques, embassies, hospitals, etc.), fortification and gates, ground cover, cemeteries, and more. Relief shown by hachures.This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.
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BACKGROUND: B cells play a role in pregnancy due to their humoral and regulatory activities. To our knowledge, different maturational stages (from transitional to memory) of circulating B cell subsets have not yet been characterized (cell quantification and phenotype identification) in healthy pregnant women. Thus, the objective of our study was to characterize these subsets (as well as regulatory B cells) from late pregnancy to post-partum and to compare them with the circulating B cells of non-pregnant women. METHODS: In all of the enrolled women, flow cytometry was used to characterize the circulating B cell subsets according to the expression of IgD and CD38 (Bm1-Bm5 classification system). Regulatory B cells were characterized based on the expression of surface antigens (CD24, CD27, and CD38) and the production of IL-10 after lipopolysaccharide stimulation. RESULTS: Compared to the absolute counts of B cells in the non-pregnant women (n = 35), those in the pregnant women (n = 43) were significantly lower (p < 0.05) during the 3rd trimester of pregnancy and on delivery day (immediately after delivery). The percentages of these cells on delivery day and at post-partum were significantly lower than those in the non-pregnant women. In general, the absolute counts and percentages of the majority of the B cell subsets were significantly lower in the 3rd trimester of pregnancy and on delivery day than in the non-pregnant women. However, these counts and percentages did not differ significantly between the post-partum and the non-pregnant women. The most notable exceptions to the above were the percentages of naïve B cells (which were significantly higher in the 3rd trimester and on delivery day than in the non-pregnant women) and of CD24(hi)CD38(hi) regulatory B cells (which were significantly higher in the post-partum than in the non-pregnant women). CONCLUSION: According to our study, the peripheral B cell compartment undergoes quantitative changes during normal late pregnancy and post-partum. Such findings may allow us to better understand immunomodulation during human pregnancy and provide evidence that could aid in the development of new strategies to diagnose and treat pregnancy-associated disturbances. Our findings could also be useful for studies of the mechanisms of maternal responses to vaccination and infection.
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Abstract BACKGROUND: B cells play a role in pregnancy due to their humoral and regulatory activities. To our knowledge, different maturational stages (from transitional to memory) of circulating B cell subsets have not yet been characterized (cell quantification and phenotype identification) in healthy pregnant women. Thus, the objective of our study was to characterize these subsets (as well as regulatory B cells) from late pregnancy to post-partum and to compare them with the circulating B cells of non-pregnant women. METHODS: In all of the enrolled women, flow cytometry was used to characterize the circulating B cell subsets according to the expression of IgD and CD38 (Bm1-Bm5 classification system). Regulatory B cells were characterized based on the expression of surface antigens (CD24, CD27, and CD38) and the production of IL-10 after lipopolysaccharide stimulation. RESULTS: Compared to the absolute counts of B cells in the non-pregnant women (n = 35), those in the pregnant women (n = 43) were significantly lower (p < 0.05) during the 3rd trimester of pregnancy and on delivery day (immediately after delivery). The percentages of these cells on delivery day and at post-partum were significantly lower than those in the non-pregnant women. In general, the absolute counts and percentages of the majority of the B cell subsets were significantly lower in the 3rd trimester of pregnancy and on delivery day than in the non-pregnant women. However, these counts and percentages did not differ significantly between the post-partum and the non-pregnant women. The most notable exceptions to the above were the percentages of naïve B cells (which were significantly higher in the 3rd trimester and on delivery day than in the non-pregnant women) and of CD24(hi)CD38(hi) regulatory B cells (which were significantly higher in the post-partum than in the non-pregnant women). CONCLUSION: According to our study, the peripheral B cell compartment undergoes quantitative changes during normal late pregnancy and post-partum. Such findings may allow us to better understand immunomodulation during human pregnancy and provide evidence that could aid in the development of new strategies to diagnose and treat pregnancy-associated disturbances. Our findings could also be useful for studies of the mechanisms of maternal responses to vaccination and infection.
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Microfilm.
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Index for all volumes: [320] pages at end of volume 8.
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Includes bibliographical references.
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Includes bibliographical references.
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In Arabic; pref. material in French.