1000 resultados para Turbina à gás
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Descrizione delle attività preliminari di progettazione di una turbina eolica auto-montante. Scopo di questo studio di fattibilità è ridurre la necessità di impiego di gru pesanti per il montaggio delle torri delle turbine eoliche. Nella tesi sono affrontati il progetto concettuale, un disegno di massima del sistema studiato per sollevare autonomamente la torre. Sono inoltre presenti alcune verifiche dei componenti più critici per confermare l'attuabilità della soluzione.
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Dimensionamento di massima ed ottimizzazione di un compressore assiale pluristadio.
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Studio e progettazione di un gruppo turbocompressore ad altissimo rapporto di compressione. Saranno progettati la girante del compressore centrifugo, il diffusore, la voluta e la girante della turbina centripeta.
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Studio del dimensionamento del radiatore e del condotto di scarico con eiettore per un motore V12 montato su elicottero.
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Studio di ottimizzazione di una turbina idraulica per piccoli stramazzi di concezione innovativa.
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Progettazione ed ottimizzazione di parte di un sistema pico-idroelettrico ad acqua fluente (potenza < 5 kW) per sfruttare grandi corsi d’acqua.
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An exact knowledge of the kinetic nature of the interaction between the stimulatory G protein (G$\sb{\rm s}$) and the adenylyl cyclase catalytic unit (C) is essential for interpreting the effects of Gs mutations and expression levels on cellular response to a wide variety of hormones, drugs, and neurotransmitters. In particular, insight as to the association of these proteins could lead to progress in tumor biology where single spontaneous mutations in G proteins have been associated with the formation of tumors (118). The question this work attempts to answer is whether the adenylyl cyclase activation by epinephrine stimulated $\beta\sb2$-adrenergic receptors occurs via G$\sb{\rm s}$ proteins by a G$\sb{\rm s}$ to C shuttle or G$\sb{\rm s}$-C precoupled mechanism. The two forms of activation are distinguishable by the effect of G$\sb{\rm s}$ levels on epinephrine stimulated EC50 values for cyclase activation.^ We have made stable transfectants of S49 cyc$\sp-$ cells with the gene for the $\alpha$ protein of G$\sb{\rm s}$ $(\alpha\sb{\rm s})$ which is under the control of the mouse mammary tumor virus LTR promoter (110). Expression of G$\sb{\rm s}\alpha$ was then controlled by incubation of the cells for various times with 5 $\mu$M dexamethasone. Expression of G$\sb{\rm s}\alpha$ led to the appearance of GTP shifts in the competitive binding of epinephrine with $\sp{125}$ICYP to the $\beta$-adrenergic receptors and to agonist dependent adenylyl cyclase activity. High expression of G$\sb{\rm s}\alpha$ resulted in lower EC50's for the adenylyl cyclase activity in response to epinephrine than did low expression. By kinetic modelling, this result is consistent with the existence of a shuttle mechanism for adenylyl cyclase activation by hormones.^ One item of concern that remains to be addressed is the extent to which activation of adenylyl cyclase occurs by a "pure" shuttle mechanism. Kinetic and biochemical experiments by other investigators have revealed that adenylyl cyclase activation, by hormones, may occur via a Gs-C precoupled mechanism (80, 94, 97). Activation of adenylyl cyclase, therefore, probably does not occur by either a pure "'Shuttle" or "Gs-C Precoupled" mechanism, but rather by a "Hybrid" mechanism. The extent to which either the shuttle or precoupled mechanism contributes to hormone stimulated adenylyl cyclase activity is the subject of on-going research. ^
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[Simon Frankfurt]
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Signatur des Originals: S 36/F10748
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Signatur des Originals: S 36/F10749