An assessment of obesity and hyperphagia in individuals with Smith-Magenis syndrome

Smith-Magenis syndrome (SMS;OMIM# 182290) is a multiple congenital anomalies and mental retardation syndrome caused by a 3.7- Mb deletion on chromosome 17p11.2 or a mutation in the RAI1 gene. Although the majority of the SMS phenotype has been well described, limited studies are available describing growth patterns in SMS. There is some evidence that individuals with SMS develop obesity. Thus, this study aims to characterize the growth and potential influence of hyperphagia in a cohort of individuals with SMS. A retrospective chart review was conducted of 78 individuals with SMS through Baylor College of Medicine (BCM) at Texas Children¡¯s Hospital (TCH.) All documented height and weight measurements were abstracted and Z-scores (SD units) for height-for-age, length-for-age and BMI-for-age were calculated. Mail-out questionnaires were provided to the corresponding parents of the cohort to assess for the presence of hyperphagia through a validated hyperphagia questionnaire (HQ). Analysis of this data demonstrates that by the age ¡Ý 20 years males with SMS have mean BMI¡¯s in the 85th-90th percentile corresponding to an overweight BMI, and females with SMS had mean BMI¡¯s in the 95th -97th percentile corresponding to an obese BMI. Parents indicated that hyperphagia is present in individuals with SMS as 76% of parent¡¯s report having to lock food away from their child. Females¡¯ age ¡Ý 20 years of age had the highest mean behavior, drive and severity scores as well as the highest BMI. Thus, this study concludes that it appears overweight and obesity, as well as hyperphagia, are present in this cohort of SMS individuals. The results of this study will hopefully enable parents and caregivers of children with SMS to take preventative measures in order to control food related behaviors present in their children as well as to prevent overweight and obesity and the associated negative health consequences.

Der Rückschritt des Zollvereins, nachgewiesen aus dem neuesten (Blend-)Werke des Herrn C. Junghanns in Leipzig, betitelt: der Fortschritt des Zollvereins : zugleich mit Kritik der Ansichten der Herren Dönniges, Brüggemann, Biersack u. Smith, nebst der Handelsbilanz des deutschen Zollvereins

Boberach: Zahlreiche statistische Angaben sollen die Notwendigkeit von Schutzzöllen beweisen

Helen Zennah Smith: Mrs. Biest pfeift [Rezension]

Jos.

Bernard Smith, Brustbild

Signatur des Originals: S 36/G02261

James Smith, Ganzfigurbildnis

Signatur des Originals: S 36/G02262

Casassas, David, La Ciudad en Llamas. La vigencia del Republicanismo comercial de Adam Smith, Madrid, Montesinos, 2011. 465 págs. ISBN 978-84-92616-74-9

Fil: Leónidas Aguirre, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas

Ingenio e imaginación : crítica al racionalismo y propuestas gnoseológico-antropológicas en Giambattista Vico y Adam Smith

Este trabajo tiene por objeto identificar algunas coincidencias entre las ideas de Giambattista Vico y Adam Smith en cuanto a los principios gnoseológico-antropológicos sobre los que asientan sus concepciones acerca del conocimiento científico-filosófico. Se intentará mostrar que ambos autores elaboraron sus posiciones filosóficas en dialogo crítico con el racionalismo, lo que les permitió reestructurar la manera de comprender y caracterizar el conocimiento humano destacando la acción de las facultades del ingenio en Vico y la imaginación en Smith.

Smith K. M. - A texbook of plant virus diseases (New second edition) J. A. Churchill Ltd, Londres, Inglaterra

Fil: Pontis, Rafael E..

Stevie Smith y los ecos con la voz del Rey Hamlet

Fil: Fernández, Silvana N.. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.

Charles Segal. Aglaia. The Poetry of Alcman, Sappho, Pindar, Bacchylides and Corinna, Maryland, Rowman y Littlefield Publishers, Ine., 1998, 339 pp.

Fil: Errecalde, Alejandro Martín. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

(Reseña sobre) Vicente Blasco Ibáñez: An Annotated Bibliography 1975-2002, de Christopher L. Anderson y Paul C. Smith

Fil: Contreras, María de los Angeles. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

C. Dué. Homeric Variations on a Lament by Briseis . Greek Studies: Interdisciplinary Approaches, Series Editor: G. Nagy, Harvard University, Rowman and Littlefield Publishers, Inc. Lanham, 2002, xi+141 pp.

Fil: Zecchin de Fasano, Graciela Cristina. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.