Revisão sobre fármacos quirais e a sua importância na medicina atual

Aspects are discussed on the chirality of drugs and their action in the human body, the benefits of using a drug in enantiomerically pure form and why, even today, despite the risks, many drugs are marketed as racemic mixture. Among the methods of separation there is the High Performance Liquid Chromatography (HPLC) which can be given in different ways using chiral additives in the mobile phase as in the system of ligand exchange in the ion pair system and the system of cavity or inclusion. Note also the wide variety of chiral stationary phases available in the market that allow high specificity using them according to the need and purpose of the method. The review of the topic is extremely important since it is a matter of public interest world that brings into play issues and financial policies

Fases de investigação geológico-geotécnica para a implantação de dutovias

The research addresses the need for detailed geological and geotechnical investigations in pipeline’s design, given the diversity of geological units crossed by these works along its layout, which often extends for hundreds of miles. For its large size, this type of work often goes through different states and regions with very different characteristics in terms of topography, vegetation, geology and geotechnical conditions. For a better use of these investigations in order to avoid unnecessary costs and inefficient results, some authors recommend that steps be taken to study, seeking a progressive detail of the pipeline’s implantation area. The main objective of the study is to describe, analyze and correlate the proposals for geological and geotechnical’s investigation recommended by the authors selected. Nogueira Junior & Marques (1998) suggest that for better effectiveness of geological and geotechnical investigations associated with the deployment of pipelines, different research methods are applied sequentially in five major stages of the building. Rocha et al (2008) recommend that, for the pipeline’s implantation using horizontal directional drilling, investigations are performed in three phases of study, to be developed in coordination with the project stages. For Gelinas & Mathy (2004), when time and budget constraints permit, geotechnical investigations for directional drilling projects for pipelines must be made in four sequential phases. Heinz (2008) suggests that the geotechnical investigations for pipeline’s implantation using horizontal directional drilling at crossings of water bodies are carried out in three successive stages. By the development of research, we could see that all the different proposals recommend studies in sequential phases, starting from a more general scale for a more specific, seeking a progressive understanding of the geological model of the area where you intend to deploy the pipeline

Estudo da adsorção e oxidação do monóxido de carbono sobre as fases intermetálicas ordenadas AuIn, AuSb2, AuSn, PdSb e PdSn

Aiming to reduce the cost of electrocatalysts and a greater resistance to CO poisoning this work was to study the adsorption and oxidation of carbon monoxide on ordered intermetallic phases AuIn, AuSb2, AuSn, PdSb and PdSn using voltammetric techniques in alkaline electrolyte solution. The results suggest that the AuSn and PdSn intermetallics has some form of resistance to CO poisoning. It is assumed that this behavior is a result of electronic effect and the effect of the third body has been achieved by adding a second metal to Au and Pd. However, further studies should be conducted to confirm this hypothesis as to test these materials as electrocatalysts in the reaction of oxidation of fuels

Separação de Isótopos por Ressonância

Devido a grande demanda do uso da energia atômica, as pesquisas sobre o processo de separação de isótopos tornam-se cada vez mais importantes. Neste trabalho mostramos uma técnica de separação de isótopos usando o efeito da ressonância.

Orações substantivas em função de sujeito e de objeto nas fases arcaica e moderna do português

Neste artigo descrevemos o comportamento de orações subjetivas e objetivas diretas nas fases arcaica (séculos XIII a XV) e moderna (séculos XVI e XVII) do português. Adotamos o quadro teórico da gramaticalização e dessentencialização de orações e discutimos resultados para os parâmetros tipo semântico do predicado matriz, unidade semântico funcional representada pela oração encaixada e formato da oração encaixada. Observamos, ao longo das sincronias, correlações sistemáticas entre os parâmetros investigados para os dois tipos oracionais. Orações subjetivas apresentam menor variedade de padrões do que orações completivas objetivas, principal diferença a interferir em suas estabilidades sintático-semânticas nos períodos investigados.

Estudo do desempenho de filmes de Ti02 como aceptor de elétrons e obtenção de fases puras de nanopartículas de Ti02: anatase e rutila, sintetizado por uma nova rota química

Pós-graduação em Ciência dos Materiais - FEIS

Modelos para estimar exigências nutricionais de aminoácidos e resposta à ingestão de metionina: sistema tradicional por fases x nutrição de precisão

Pós-graduação em Zootecnia - FCAV

Materiais híbridos argila-poli(metil metacrilato) obtidos através do método grafting

Pós-graduação em Química - IQ

Turnover do carbono em sangue e plasma, nas fases crescimento e postura, de codornas japonesas (Coturnix coturnix japonica)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Preparação e caracterização de membranas de celulose regenerada a partir da celulose extraída de resíduos agroindustriais para aplicação em processos de separação

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Solução das equações de Navier-Stokes e da equação de transporte por um método de elementos finitos estabilizado pela técnica de separação baseada na característica

Pós-graduação em Engenharia Mecânica - FEIS

Positividade do imunomarcador FOXP3 em células T reguladoras em lesões de micose fungoide em fases clínicas iniciais e em dermatoses inflamatórias como fator auxiliar para o diagnóstico diferencial

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

As fases do treinamento de natação influenciam os substratos energéticos, cortisol e leucócitos

The effect of physical exercise in immune function has been extensively studied. The intensity and duration of physical exercise have considerable influence in immunologic parameters. However, few studies have compared different exercise intensities in different stages of a physical training program. Thus, the aim of this study was to verify the metabolic, hormonal and immunologic changes before and after acute intermittent swimming exercise, following different stages of training program. Seventeen male swimmers were evaluated in three stages of training. The intensity of the three sessions was 90% (anaerobic potency – PAN), 70% (aerobic potency - PAE) and 98% (lactate tolerance – TLA) of the maximal speed from the best time of the distance, resulted from peak performance in competition. Blood samples were collected pre and immediately after exercise for cells counting and measurement of substrates and cortisol concentrations. It was used ANOVA to verify the significance of difference (p<0.05). There was a significant increase of glucose and cortisol post exercise in the PAN and PAE sessions. Glutamine increased significantly in PAE and TLA. Leukocytes increased significantly after the three different sessions and lymphocytes decreased significantly on PAE and TLA. In conclusion, it was demonstrated that changes of the several parameters studied in different stages of training program can cause temporary alterations in immune cells and may compromise resistance to common minor illnesses and athlete performance.

Uma proposta de atividade para a aprendizagem significativa sobre as fases da Lua

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)