Multicointegration, polynomial cointegration and I(2) cointegration with structural breaks. An application to the sustainability of the US external deficit

In this paper we model the multicointegration relation, allowing for one structural break. Since multicointegration is a particular case of polynomial or I(2) cointegration, our proposal can also be applied in these cases. The paper proposes the use of a residualbased Dickey-Fuller class of statistic that accounts for one known or unknown structural break. Finite sample performance of the proposed statistic is investigated by using Monte Carlo simulations, which reveals that the statistic shows good properties in terms of empirical size and power. We complete the study with an empirical application of the sustainability of the US external deficit. Contrary to existing evidence, the consideration of one structural break leads to conclude in favour of the sustainability of the US external deficit.

Another Look at the Null of Stationary Real Exchange Rates: Panel Data with Structural Breaks and Cross-section Dependence

This paper re-examines the null of stationary of real exchange rate for a panel of seventeen OECD developed countries during the post-Bretton Woods era. Our analysis simultaneously considers both the presence of cross-section dependence and multiple structural breaks that have not received much attention in previous panel methods of long-run PPP. Empirical results indicate that there is little evidence in favor of PPP hypothesis when the analysis does not account for structural breaks. This conclusion is reversed when structural breaks are considered in computation of the panel statistics. We also compute point estimates of half-life separately for idiosyncratic and common factor components and find that it is always below one year.

På Roines strand

Soitinnus: lauluääni, piano.

Microphotometric scanning of chromatid gaps and breaks induced by AluI and BamHI in Chinese hamster ovary cells

Chromatid gaps and breaks induced by the restriction endonucleases AluI and BamHI in the long arm of chromosome 1 of Chinese hamster ovary cells were microphotometrically scanned and mapped to a quantitative G-band map. More than 50% of chromatid breaks appeared as chromatin losses of greater than 5% of the total arm length. The majority of chromatid gaps and breaks as well as chromatin losses induced by both restriction endonucleases were non-randomly located in a region from 0.35 to 0.65 relative length units of the long arm of chromosome 1. We suggest that the access of these endonucleases to chromosomal DNA depends on the local organization of the chromatin.

Detection of point mutations by non-isotopic single strand conformation polymorphism

We have developed a procedure for nonradioactive single strand conformation polymorphism analysis and applied it to the detection of point mutations in the human tumor suppressor gene p53. The protocol does not require any particular facilities or equipment, such as radioactive handling, large gel units for sequencing, or a semiautomated electrophoresis system. This technique consists of amplification of DNA fragments by PCR with specific oligonucleotide primers, denaturation, and electrophoresis on small neutral polyacrylamide gels, followed by silver staining. The sensitivity of this procedure is comparable to other described techniques and the method is easy to perform and applicable to a variety of tissue specimens.

Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer

Breast cancer in families with germ line mutations in the TP53 gene has been described in the medical literature. Mutation screening for susceptibility genes should allow effective prophylactic and preventive measures. Using single-strand conformational polymorphism, we screened for mutations in exons 5, 6, 7 and 8 of gene TP53 in the peripheral blood of 8 young non-affected members (17 to 36 years old) of families with a history of breast cancer. Studies of this type on young patients (mean age, 25 years) are very rare in the literature. The identification of these mutations would contribute to genetic counseling of members of families with predisposition to breast cancer. The results obtained did not show any polymorphism indicating mutation. In our sample, the familial tumorigenesis is probably related to other gene etiologies.

Screening for mutations in human alpha-globin genes by nonradioactive single-strand conformation polymorphism

Point mutations and small insertions or deletions in the human alpha-globin genes may produce alpha-chain structural variants and alpha-thalassemia. Mutations can be detected either by direct DNA sequencing or by screening methods, which select the mutated exon for sequencing. Although small (about 1 kb, 3 exons and 2 introns), the alpha-globin genes are duplicate (alpha2 and alpha1) and highy G-C rich, which makes them difficult to denature, reducing sequencing efficiency and causing frequent artifacts. We modified some conditions for PCR and electrophoresis in order to detect mutations in these genes employing nonradioactive single-strand conformation polymorphism (SSCP). Primers previously described by other authors for radioactive SSCP and phast-SSCP plus denaturing gradient gel electrophoresis were here combined and the resultant fragments (6 new besides 6 original per alpha-gene) submitted to silver staining SSCP. Nine structural and one thalassemic mutations were tested, under different conditions including two electrophoretic apparatus (PhastSystem™ and GenePhor™, Amersham Biosciences), different polyacrylamide gel concentrations, run temperatures and denaturing agents, and entire and restriction enzyme cut fragments. One hundred percent of sensitivity was achieved with four of the new fragments formed, using the PhastSystem™ and 20% gels at 15ºC, without the need of restriction enzymes. This nonradioactive PCR-SSCP approach showed to be simple, rapid and sensitive, reducing the costs involved in frequent sequencing repetitions and increasing the reliability of the results. It can be especially useful for laboratories which do not have an automated sequencer.

Plan karta öfver de ställen i närheten af Willmanstrand, der spår förekomma efter en påbörjad genomgräfning af Saimas strand-ås, för att förena Saima med Juustila å.

Alareunassa kanavan pituus- ja korkeusmittakaavaan piirretty sivuprofiili: Profil öfver det ställe af Saima strand-ås, der spår förekomma af en äldre kanalgräfning (detta ställe benämnes: Pontuksen uusi kaiwando).

[Topografičeskaâ karta 1:42000]. XIII-45, XIII-46, XII-45, XII-46, Vyborg. gub., Vil'manstr., Kûmen. i Strand. uěz.

1:42000.

COMP3016 Web Technology - Strand 3 "History" Lecture 1

Lecture 1: The Pioneers and History of Hypertext (pre-WWW) Contains Powerpoint Lecture slides and Hypertext Research Papers: Bush: As We may Think; Engelbart: NLS and A Framework for Augmenting Human Intelligence; Nelson: Xanalogical Structure; Conklin: A Survey of Hypertext; Halasz 1987: Reflections on NoteCards: Seven Issues for the Next Generation of Hypermedia Systems; Berners-Lee 1994 The World-Wide Web.

COMP3016 Web Technology - Strand 3 "History" Lecture 2

Lecture 1: Contributions of Pre WWW Research: Open Hypermedia Systems Contains Powerpoint Lecture slides and Hypertext Research Papers: Industrial Strength Hypermedia: Requirements for a Large Engineering Enterprise (Malcolm et al. 1991); Towards An Integrated Information Environment With Open Hypermedia Systems (Davis et al. 1992); Unifying Strategies for Web Augmentation (Bouvin 1999); Hyper-G (Adapted from Lowe and Hall); OHP:A Draft Proposal for a Standard Open Hypermedia Protocol (Davis et al. 1996); XML Linking (DeRose 99)

COMP3016 Web Technology - Strand 3 "History" Lecture 3

Lecture 3: Contributions of Pre WWW Research: Spatial Hypertext and Temporal Hypertext Contains Powerpoint Lecture slides and Hypertext Research Papers: Spatial [SPATIAL] VIKI: spatial hypertext supporting emergent structure (Marshall, 94); Towards Geo-Spatial Hypermedia: Concepts and Prototype Implementation, (Gronbaek et al. 2002); Cyber Geography and Better Search Engines; [TEMPORAL] Anticipating SMIL 2.0: The Developing Cooperative Infrastructure for Multimedia on the Web (Rutledge 1999); Its About Time: Link Streams as Continuous Metadata (Page et al., 2001); Everything You Wanted to Know About MPEG-7:Part 1 (Nack & Lindsay 1999)