Prognostic Role of Host Cyclooxygenase and Cytokine Genotypes in a Caucasian Cohort of Patients with Gastric Adenocarcinoma

11 p.

Carta enviada por Luis Arregi a Justo Garate en 1988

1 carta (manuscrita) ; 161x225mm. Ubicación: Caja 1 - Carpeta 57

The Economics of Gasification: A Market-Based Approach

This paper deals with the economics of gasification facilities in general and IGCC power plants in particular. Regarding the prospects of these systems, passing the technological test is one thing, passing the economic test can be quite another. In this respect, traditional valuations assume constant input and/or output prices. Since this is hardly realistic, we allow for uncertainty in prices. We naturally look at the markets where many of the products involved are regularly traded. Futures markets on commodities are particularly useful for valuing uncertain future cash flows. Thus, revenues and variable costs can be assessed by means of sound financial concepts and actual market data. On the other hand, these complex systems provide a number of flexibility options (e.g., to choose among several inputs, outputs, modes of operation, etc.). Typically, flexibility contributes significantly to the overall value of real assets. Indeed, maximization of the asset value requires the optimal exercise of any flexibility option available. Yet the economic value of flexibility is elusive, the more so under (price) uncertainty. And the right choice of input fuels and/or output products is a main concern for the facility managers. As a particular application, we deal with the valuation of input flexibility. We follow the Real Options approach. In addition to economic variables, we also address technical and environmental issues such as energy efficiency, utility performance characteristics and emissions (note that carbon constraints are looming). Lastly, a brief introduction to some stochastic processes suitable for valuation purposes is provided.

The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers

Background: The aim of this study is to examine the influence of the catechol-O-methyltranferase (COMT) gene (polymorphism Val158 Met) as a risk factor for Alzheimer's disease (AD) and mild cognitive impairment of amnesic type (MCI), and its synergistic effect with the apolipoprotein E gene (APOE). A total of 223 MCI patients, 345 AD and 253 healthy controls were analyzed. Clinical criteria and neuropsychological tests were used to establish diagnostic groups. The DNA Bank of the University of the Basque Country (UPV-EHU) (Spain) determined COMT Val158 Met and APOE genotypes using real time polymerase chain reaction (rtPCR) and polymerase chain reaction (PCR), and restriction fragment length polymorphism (RFLPs), respectively. Multinomial logistic regression models were used to determine the risk of AD and MCI. Results: Neither COMT alleles nor genotypes were independent risk factors for AD or MCI. The high activity genotypes (GG and AG) showed a synergistic effect with APOE epsilon 4 allele, increasing the risk of AD (OR = 5.96, 95% CI 2.74-12.94, p < 0.001 and OR = 6.71, 95% CI 3.36-13.41, p < 0.001 respectivily). In AD patients this effect was greater in women. In MCI patients such as synergistic effect was only found between AG and APOE epsilon 4 allele (OR = 3.21 95% CI 1.56-6.63, p = 0.02) and was greater in men (OR = 5.88 95% CI 1.69-20.42, p < 0.01). Conclusion: COMT (Val158 Met) polymorphism is not an independent risk factor for AD or MCI, but shows a synergistic effect with APOE epsilon 4 allele that proves greater in women with AD.

Annaes do Parlamento Brazileiro. Tomo I [1878]

Anais do Parlamento Brasileiro, 1878.

Annaes do Parlamento Brazileiro. Tomo II [1878]

Anais do Parlamento Brasileiro, 1878.

Annaes do Parlamento Brazileiro. Tomo III [1878]

Anais do Parlamento Brasileiro, 1878.

Annaes do Parlamento Brazileiro. Tomo IV [1878]

Anais do Parlamento Brasileiro, 1878.

Luis Badosa: vida y obra. Aproximación a la obra pictórica a través de su vivencia

487 p. : il., col.

Análisis de una metodología para el estudio de los textos del periodismo de investigación.

493 p.

Optimal Investment in Energy Efficiency under Uncertainty

41 p.

Optimal Abandonment of Coal-Fired Stations in the EU

36 p.

Valuation of wind energy projects: A real options approach

27 p.

Cartas enviadas por Augusto Barcia a Justo Garate entre 1944 y 1960

9 cartas (manuscritas) ; entre 225x140mm y 220x285mm

Cartas enviadas por José Manuel Barrenechea a Justo Garate entre 1981 y 1982

4 cartas (manuscritas) ; entre 210x260mm y 150x200mm